Moritz Gerster
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- Reposted by Moritz GersterOur new preprint on promises and caveats of the extraction of M/EEG activity from ROIs is out (see more details in the reposted thread): www.biorxiv.org/content/10.6... Huge thanks to @studenova.bsky.social, Ruben Eguinoa, Guido Nolte, @sparsity.bsky.social, Arno Villringer, and Vadim Nikulin!
- I use EEG/MEG. When I meet like-minded researchers at conferences, the discussion always circles back to one thing: admitting that results may be confounded by leakage (also known as remaining field spread—RFS). In our new preprint, we quantify RFS in parcellated data using cross-talk function—CTF.🧵
- Parkinson’s disease involves two major abnormalities in subthalamic nucleus activity: 1️⃣ Excessive beta (13–30 Hz) rhythms 2️⃣ Increased neuronal firing Beta can be measured 𝗮𝗳𝘁𝗲𝗿 surgery using deep brain stimulation electrodes.
- Deep brain stimulation can improve Parkinson’s disease symptoms, but selecting the optimal stimulation contact still relies on laborious trial-and-error.
- @andreashorn.org and @julianneumann.bsky.social proposed that the contact with the largest beta power in the STN could guide stimulation targeting. Natasha Darcy corroborated this in a large cohort, and I wondered whether optimized signal processing could strengthen the result further.
- A neuron can only do two things: Fire. Don’t fire. Firing is the neuron’s output, and most theories of neural computation treat that output as the brain's core information signal. 🧵
- Imagine you run an experiment with 50 subjects and find a significant effect just below p < 0.05. Another research group tries to replicate your finding, so they also recruit 50 people. If your methodology was perfect, what’s the chance the replication succeeds? 95%? 80%? It’s only 50% 🤯 👇🧵
- Thank you @mpicbs.bsky.social for covering our study! And thank you for fostering such an inspiring, intellectually vibrant, and genuinely supportive research environment — it was an exceptional place to do a PhD 🙏
- Noise as a Signal – Moritz Gerster, Vadim Nikulin & Arno Villringer analysed data from 119 patients & discovered a new electrical signature of #Parkinson’s Disease, now published in @ebiomedicine.bsky.social: www.cbs.mpg.de/2412209/2025... #parkinsontherapy #clinicalstudy
- Now out in @ebiomedicine.bsky.social! 📖 Read the open-access article: authors.elsevier.com/sd/article/S... #Neuroscience #Neurology #Parkinsonsdisease #Parkinsons #DeepBrainStimulation #DBS #Neurotechnology #Neuromodulation #Neurophysiology #BasalGanglia #OpenScience #Reproducibility
- How does subthalamic activity relate to Parkinson’s disease symptoms? In a truly collaborative effort across #DBS centers, we aggregated a diverse dataset of invasive recordings from 119 patients. Full article: doi.org/10.1101/2025... Main findings 🧵⬇️
- How does subthalamic nucleus activity relate to Parkinson’s disease symptoms? My last 5 years of Parkinson’s disease research summarized in 5 minutes at the DGKN Congress 2025 :) youtu.be/M9alDh836oU ⬇️ Full preprint: doi.org/10.1101/2025... #Parkinsonsdisease #Parkinsons #DeepBrainStimulation
- How does subthalamic activity relate to Parkinson’s disease symptoms? In a truly collaborative effort across #DBS centers, we aggregated a diverse dataset of invasive recordings from 119 patients. Full article: doi.org/10.1101/2025... Main findings 🧵⬇️
- #Reproducibility analysis: ↳ Levodopa modulates theta more strongly than beta oscillations. ↳ Beta does not consistently correlate with symptoms in single datasets. ↳ Replicating previous correlations requires cohorts of over 100 patients.
