Martin J. Dahl
research scientist interested in how our brain's neuromodulatory systems are linked to cognition
Lifespan Neuromodulation group (https://www.mpib-berlin.mpg.de/line)
Max Planck Institute for Human Development & University of Southern California
- Reposted by Martin J. DahlExcited to share newly minted PhD Anu Korukonda's tour de force thesis work describing the impact of pathogenic tau on #locuscoeruleus function in a mouse model of early #Alzheimers. A must for #BlueSpot researchers! www.biorxiv.org/content/10.6... 1/3
- Reposted by Martin J. DahlThe Neuromodulatory Subcortical Systems PIA within @istaart.bsky.social is requesting nominations for the best paper of 2025 on neuromodulatory subcortical systems in Alzheimer's disease!! ISTAART members: promote the work of your colleagues (or yourself) here: alz.surveymonkey.com/r/Publicatio...
- Reposted by Martin J. DahlExcited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5
- Reposted by Martin J. DahlfMRI signals “up,” but neural metabolism might be going “down.” In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes. rdcu.be/eUPO8 funds @erc.europa.eu #neuroskyence 🧵:
- Reposted by Martin J. Dahl'Robust circular cluster-based statistics for respiration-brain coupling' New preprint, and what a way to welcome @teresaberther.bsky.social to the #neuroskyence community. With @eliobalestrieri.bsky.social, she developed CBPT for circular #bodybrain analyses. Paper: osf.io/preprints/ps... 🧵🔽
- Reposted by Martin J. DahlOur paper and research on a #taVNS #MRI setup has now been published: onlinelibrary.wiley.com/doi/10.1111/... @nbkroemer.bsky.social @glassybrain.bsky.social
- #TaVNS inside the MR scanner IS POSSIBLE! ⚡🧠 I hope that this paper and its guidance on the taVNS MRI set-up will help those planning concurrent #fMRI and #vagusnervstimulation Checkout our new preprint osf.io/preprints/ps... Endless gratitude to @nbkroemer.bsky.social & @glassybrain.bsky.social
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- Reposted by Martin J. DahlOur paper on CSF, BOLD, pupil, and physiological measures in sleep deprivation and recovery sleep is finally out! 🎉 Congrats Zinong! www.nature.com/articles/s41...
- At #ICON? – Join us tomorrow to hear about novel measurement & manipulation approaches for neuromodulatory systems! 🗓️Sept 19, 🕚11:45 am 🏫Room Sé #ICON2025 #CogNeuro #AcademicSky #LocusCoeruleus #neuroskyence
- Featuring the stellar @mariekeweijs.bsky.social @juliankosciessa.bsky.social @claireocallaghan.bsky.social as well as the 🦋-less Sarah Meissner & Prokopis Prokopiou!
- Reposted by Martin J. DahlWe showed previously that chemogenetic activation of the LC rescues spatial reversal learning in the TgF344-AD rat. New paper follows up and reports that optogenetic stimulation of LC terminals in CA1 also rescues cognitive deficits in 3xTg mouse model of AD. link.springer.com/article/10.1...
- Reposted by Martin J. DahlAdaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level). If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...
- Reposted by Martin J. DahlNew study out in Nature Medicine: Education does not protect against age-related decline of memory. Read more here: Reevaluating the role of education on cognitive decline and brain aging in longitudinal cohorts across 33 Western countries www.nature.com/articles/s41...
- Reposted by Martin J. DahlGreat (and lots of) work from Mike David and many colleagues using #pupillometry #EEG #MRI to understand arousal and #locuscoeruleus changes in #AlzheimersDisease. Out now in @braincomms.bsky.social academic.oup.com/braincomms/a...
- Reposted by Martin J. DahlBeyond happy & proud to have our paper on peptidergic neuromodulation of the #LC out! This is a project that started with naive intentions & silly curiosity, withstood 1 pandemic & 2 lab moves & made us fall in ❤️ with the most beautiful brain regions of all!! 🔵 www.science.org/doi/10.1126/...
- Reposted by Martin J. DahlOur oscillations consensus paper is finally out as a preprint 🤩 thanks to everyone involved arxiv.org/abs/2507.15639
- /1 We took our sweet time (~3yrs) to put this into its final shape - but happy to say that the pre-print of an extensive review of brain rhythms in cognition - from a cognruro perspective - is now available. Please let us know what you think. #neuroskyence doi.org/10.48550/arX...
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- Reposted by Martin J. DahlSuper happy to see our latest work out in @plosbiology.org : N2 sleep during short naps increased the likelihood of insight in a decision task. The steepness of the spectral slope best predicted insight, beyond sleep stages alone. With dream team @maritpetzka.bsky.social @nicoschuck.bsky.social
- That "Aha!" moment... Can sleep facilitate memory reorganization? @nicoschuck.bsky.social @anikaloewe.bsky.social @maritpetzka.bsky.social &co reveal that N2 #sleep (but not N1) increases likelihood of having an 'aha' moment about a previous #DecisionMaking task @plosbiology.org 🧪 plos.io/4k8F2v3
- Reposted by Martin J. DahlPulsed taVNS elicits pupil dilation. However, if sham feels as intense, there is not much left. Based on our comparatively large sample (94 participants, single-blind crossover), we show that a highly variable sham response explains this. #neuroskyence 🩺 www.biorxiv.org/content/10.1...
- Reposted by Martin J. DahlAfter years of hard work, @hashimsat.bsky.social's big one is out! Huge thanks to co-authors Katharina Wille, Matt Nassar, Radek Cichy, @nicoschuck.bsky.social & Peter Dayan - and to @haukeren.bsky.social for his invaluable support!
- 🚨 New preprint alert! Our project investigating the effects of internalizing and trait anxiety on learning under uncertainty is finally online 🐆🐅 www.biorxiv.org/content/10.1...
- Reposted by Martin J. DahlExcited to share that the astrocyte-centered half of my thesis work is now out @science.org ! With @mishaahrens.bsky.social and @marcduque.bsky.social science.org/doi/10.1126/... 1/8
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- Reposted by Martin J. DahlA time window for memory consolidation during NREM sleep revealed by cAMP oscillation: Neuron www.cell.com/neuron/fullt...
- Reposted by Martin J. DahlMy paper reviewing how different neurodegenerative diseases affect autonomic function was just published.
- Autonomic dysfunction in neurodegenerative disease — a Review by Mara Mather www.nature.com/articles/s41... @maramather.bsky.social #neuroscience
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- Reposted by Martin J. DahlTranscutaneous auricular vagus nerve stimulation (taVNS) and fMRI: a great combination to test the mechanism of action driving stimulation effects 🧠 But how to use the stimulation safely within the magnetic field? We looked into this! #neuroskyence doi.org/10.31234/osf...
- Reposted by Martin J. Dahl👉👉new paper alert from @labluthi.bsky.social - so proud for talented and determined Dr.Najma Cherrad who opened the lab‘s access to brain-body communication! #sleep #locuscoeruleus #parasympathetic @fbm-unil.bsky.social
- Reposted by Martin J. DahlCheck out a new lab paper from Mayumi Watanabe's thesis work showing how different subregions of medial prefrontal cortex differentially regulate extinction of aversive memories through projections to the locus-coeruleus-noradrenaline system: doi.org/10.1038/s413...
- Reposted by Martin J. DahlWith support from @istaart.bsky.social, we are organizing the first Integrative Neuromodulatory Subcortical Systems meeting in collab with Sleep and Circadian Rhythms PIA! WHEN/WHERE: Boston, MGH/Martinos Center on July 17-18; info, register & submit your abstract: education.martinos.org/inss2025/
- Reposted by Martin J. DahlIn our new @commspsychol.bsky.social review, we explore how humans adjust learning to different types of uncertainty, why biases arise, and what this reveals about learning and psychiatric conditions. 📖 Read more: nature.com/articles/s44... With Matt Nassar & @haukeren.bsky.social
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- Reposted by Martin J. DahlDoes tVNS elicit replicable effects beyond BOLD responses in the brainstem? Yes, pulsed, but not conventional tVNS leads to robust pupil dilation in our new meta-analysis. Published in Brain Stim w/ @cecivez.bsky.social @akuehnel.bsky.social #neuroskyence 🩺 www.sciencedirect.com/science/arti...
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- Reposted by Martin J. Dahl📢 New preprint from the lab: We are very excited to report the discovery of an oscillation in the Central Thalamus using rare direct recordings of human thalamic electrophysiology. The novel oscillation is tightly coupled to specific, natural states of consciousness.🧵
- Thalamic oscillations distinguish natural states of consciousness in humans biorxiv.org/content/10.1101/202…
- Reposted by Martin J. DahlHappy 30th birthday year to SPM!! 🎈🍰 To get the party started, we are delighted to announce SPM 25.01, a major new version of the open-source neuroimaging software. Read the preprint to discover what's new arxiv.org/pdf/2501.12081 and download SPM for free from Github github.com/spm/spm/rele...
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- Reposted by Martin J. DahlI am very much looking forward to this week with 2 meetings of the Neuromodulatory Subcortical System PIA: 📌 Tiny dots 21.01.25 12.30am CT (USA) - Noradrenergic Axon Loss Drives Hyposmia in AD alz-org.zoom.us/webinar/regi... 📌 Year in Review 24.01.25 10am CT (USA) alz-org.zoom.us/webinar/regi...
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- Reposted by Martin J. Dahl*How* does the hippocampus encode the world around us? Leo Waschke and Fabian Kamp bring the 🔥, showing that single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans. Our latest in Nature Communications: www.nature.com/articles/s41...
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- Reposted by Martin J. Dahl🚨Short bursts of taVNS ⚡ & 👁️ pupil dilation - as an indirect measure of #LocusCoeruleus (?!) #vagusnerv #taVNS Link to publication: www.nature.com/articles/s41... I systematically tested different frequencies (10 & 25 Hz) and intensities (3 & 5 mA) during 3 sec of short bursts of taVNS
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