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Alex Chase 🧬🌋🌊

microbomics.bsky.social

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Assist Prof of Earth Sciences at SMU Microbial ecologist 🔬🦠 English bulldog enthusiast 🐶🐾

Joined November 2024

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Paul Carini uncultured.carinilab.com · Dec 15, 2025
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Dave Baltrus 🦦 handle.invalid · Dec 15, 2025
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Pete Homyak petehomyak.bsky.social · Dec 15, 2025
#AGU25 B22F. Geoclimatic Drivers of Nitric Oxide (NO), Nitrous Oxide (N2O), and Nitrogen (N2) Emissions: Microscale to Global-Scale Controls I Oral Day/Time: Tuesday, 16 December 2025: 10:30 - 12:00, NOLA CC, New Orleans Theater A @agubiogeosciences.bsky.social

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Cameron Thrash jcamthrash.bsky.social · Dec 8, 2025
Uneven sequencing (coverage) depth can bias microbial intraspecies diversity estimates and how to account for it academic.oup.com/ismecommun/a... #jcampubs

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Alex Crits-Christoph handle.invalid · Dec 8, 2025
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ISME - International Society for Microbial Ecology handle.invalid · Dec 8, 2025
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Will Ratcliff handle.invalid · Dec 9, 2025
1/28 New preprint up, which I think is the best theoretical idea I've ever had. We asked a simple question: what are the costs of investment into non-reproductive somatic cells? Turns out these costs decrease with the *logarithm* of organism size! www.biorxiv.org/content/10.6...
The fitness costs of reproductive specialization scale inversely with organismal size

The evolution of reproductive specialization represents a fundamental innovation in multicellular life, yet the conditions favoring its evolution remain poorly understood. Here, we develop a populatio...

biorxiv.org

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Microbes.Info microbesinfo.bsky.social · Oct 30, 2025
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Alejandro Rodríguez-Gijón handle.invalid · Oct 6, 2025
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Tami Lieberman handle.invalid · Aug 18, 2025
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alexjaf alexjaf.bsky.social · Aug 18, 2025
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Adrià Auladell adriaula.bsky.social · Aug 18, 2025
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David Pollock handle.invalid · Aug 18, 2025
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David Pollock handle.invalid · Aug 18, 2025
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Cameron Thrash jcamthrash.bsky.social · Jun 18, 2025
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Elinne Becket, PhD bielleogy.bsky.social · Jun 18, 2025
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Alex Crits-Christoph handle.invalid · Jun 13, 2025
There is so, so much good science being shared and discussed on bsky right now. The news of its demise is quite backwards. If you are having trouble finding it among all of the very important political news, use the papersky feed that filters posts you follow to just papers: bsky.app/profile/pape...
Feed: did:plc:uaadt6f5bbda6cycbmatcm3z/preprintdigest

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Jonathan Eisen phylogenomics.bsky.social · May 27, 2025
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Ákos T Kovács handle.invalid · May 15, 2025
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Dave Baltrus 🦦 handle.invalid · May 14, 2025
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Cameron Thrash jcamthrash.bsky.social · May 15, 2025
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Roland Hatzenpichler environmicrobio.bsky.social · May 15, 2025
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Alex Crits-Christoph handle.invalid · May 8, 2025
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Cameron Thrash jcamthrash.bsky.social · May 5, 2025
Our latest led by former postdoc Brittany Bennett- this has microscopy, physiology, gene expression, mass-spec, and even heterologous expression! Polyhydroxybutyrate production by freshwater SAR11 (LD12) academic.oup.com/ismej/advanc... #jcampubs
Polyhydroxybutyrate production by freshwater SAR11 (LD12)

Abstract. SAR11 bacteria (order Pelagibacterales) are oligotrophs and often the most abundant bacterioplankton in aquatic environments. A subset of sequenc

academic.oup.com

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Alex Crits-Christoph handle.invalid · Apr 28, 2025
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Dave Baltrus 🦦 handle.invalid · Apr 14, 2025
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Sebastian S. Cocioba atinygreencell.bsky.social · Mar 8, 2025
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Dan Udwary danudwary.secondarymetabolism.com · Mar 5, 2025
Preprint for @wildtypemc.bsky.social 's GATOR-GC is out! Have been looking forward to using this to explore secondary metabolite BGCs! www.biorxiv.org/content/10.1...
Targeted genome mining with GATOR-GC maps the evolutionary landscape of biosynthetic diversity

Gene clusters, groups of physically adjacent genes that work collectively, are pivotal to bacterial fitness and valuable in biotechnology and medicine. While various genome mining tools can identify a...

biorxiv.org

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Sullivan Lab at OSU sullivan-lab.bsky.social · Mar 5, 2025
🚨New paper from NSF EMERGE BII: A framework for integrating genomics, microbial traits, and ecosystem biogeochemistry. Read here: www.nature.com/articles/s41...
A framework for integrating genomics, microbial traits, and ecosystem biogeochemistry - Nature Communications

Microbes drive the Earth’s biogeochemical cycles. Here, Li et al. present a framework for integrating genome-inferred microbial kinetic traits into ecosystem mechanistic models, and use it to benchmar...

nature.com

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Sebastian S. Cocioba atinygreencell.bsky.social · Jan 30, 2025
I think the Microbial Evolution feed is working! Simply add the #MEvoSky hashtag to your post and it will aggregate to the feed linked below. Feel free to introduce yourself in context of microbial evo and adjacent topics. Experimental and directed evo welcome too! bsky.app/profile/did:...
Feed: Microbial Evolution

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jewilki jewilki.bsky.social · Dec 22, 2024
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Dr. Sydney Glassman sydneyglassman.bsky.social · Dec 20, 2024
New Glassman lab paper led by my former PhD student Fabi! Some of you may remember the Stirling Ultracold freezer saga of 2020. Well, we made lemonade out of lemons! If this happens to you don’t rush to throw everything away. journals.asm.org/doi/10.1128/...
Not all is lost: resilience of microbiome samples to freezer failures and long-term storage | mSphere

Microbiome studies heavily rely on ultracold freezers for sample storage. Unfortunately, these freezers are prone to frequent malfunctions, resulting in the loss of invaluable samples at laboratories worldwide. Such losses can halt research progress due ...

journals.asm.org

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Marc Chevrette wildtypemc.bsky.social · Dec 20, 2024
Somehow I have been more productive in the last 3 days than the rest of 2024 combined

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Dr. Jennifer Pett-Ridge jeffinerca.bsky.social · Dec 12, 2024
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giannamars giannamars.bsky.social · Dec 11, 2024
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Elsa Abs elsa-abs.bsky.social · Dec 9, 2024
I’m at #AGU24 all week! 📋Come to my poster on Wed morning to chat about integrating microbial diversity and adaptation into ecosystem models. 🗣️Come to our 2 oral sessions Wed afternoon to talk about improving soil carbon predictions. ☕️And message me to chat over coffee!

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Elsa Abs elsa-abs.bsky.social · Dec 4, 2024
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alexjaf alexjaf.bsky.social · Nov 25, 2024
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Dr. Jennifer Pett-Ridge jeffinerca.bsky.social · Nov 23, 2024
Buried paleosols hold a LOT of #Carbon. What happens when they are exposed? McMurtry et al. show “paleosols defy expectations of C content and reactivity” Getting to the root of the problem: Soil carbon and microbial response... www.sciencedirect.com/science/arti...
Getting to the root of the problem: Soil carbon and microbial responses to root inputs within a buried paleosol along an eroding hillslope in southwestern Nebraska, USA

Large quantities of soil carbon (C) can persist within paleosols for millennia due to burial and subsequent isolation from plant-derived inputs, atmos…

sciencedirect.com

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Marc Chevrette wildtypemc.bsky.social · Nov 22, 2024
Nice to see this wonderful story published. Congrats to Erin and Michael and all involved. pubs.acs.org/doi/10.1021/...
Directed Evolution of an Adenylation Domain Alters Substrate Specificity and Generates a New Catechol Siderophore in Escherichia coli

Nonribosomal peptide synthetases (NRPS) biosynthesize numerous natural products with therapeutic, agricultural, and industrial significance. Reliably altering substrate selection in these enzymes has been a longstanding goal, as this would enable the production of tailor-made peptides with desired activities. In this study, the NRPS EntF and the associated biosynthesis of the siderophore enterobactin (ENT) were used as a model system to interrogate substrate selection by an adenylation (A) domain. We employed a directed evolution pipeline that harnesses an in vivo genetic selection for siderophore production to alter A domain substrate selection. Surprisingly, this led to the formation of a new, physiologically active catechol siderophore in Escherichia coli. We characterized the enzyme variants in vitro and demonstrated transferability of our findings to the well-studied TycC and GrsB NRPSs. This work identifies critical binding pocket residues that allow for altered substrate selection in our model system and expands upon our understanding of iron acquisition in E. coli.

pubs.acs.org

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chasingmicrobes handle.invalid · Nov 21, 2024
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ nizet.bsky.social · Nov 18, 2024
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Elsa Abs elsa-abs.bsky.social · Nov 20, 2024
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Jonathan Eisen phylogenomics.bsky.social · Nov 16, 2024
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Alex Crits-Christoph handle.invalid · Nov 10, 2024
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James McInerney jomcinerney.bsky.social · Nov 9, 2024
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Alex Crits-Christoph handle.invalid · Nov 7, 2024
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malladapted malladapted.bsky.social · Nov 7, 2024
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Matthias C. Rillig mrillig.bsky.social · Nov 6, 2024
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Dave Baltrus 🦦 handle.invalid · Nov 6, 2024
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