Matt Bogyo
Chemical biologist at Stanford with a love for covalent binding molecules and hydrolases.
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- Our latest work developing AND-gate probes to image inflammation is out. Great work from Shiyu Chen and collaboration with the group at Merck. pubs.acs.org/articlesonre...
- After a long journey and much hard work from many talented scientists, our paper is finally out. Take a look if you are interested in proteases and host microbe interactions in the gut. www.cell.com/cell-host-mi...
- Thrilled to be speaking at the McCaig International Research Conference on #Osteoarthritis, March 11–13, 2026 in Kananaskis, Alberta 🇨🇦. Trainee abstract submissions open until Oct 31, 2025! mccaig.ucalgary.ca/event/intern... #McCaig2026 #BoneAndJointHealth
- Great collaboration with @derda_lab @RatmirDerda just posted to bioRxiv. Check out how to best incorporate electrophiles into cyclic peptides to generate covalent inhibitors. www.biorxiv.org/content/10.1...
- Having a great time as a senior visiting faculty at Nanyang Technological University in Singapore hosted by Professor Kanyi Pu. Great people and great science.
- Macrocyclic Phage Display for Identification of Selective Protease Substrates | Journal of the American Chemical Society pubs.acs.org/doi/full/10....
- Our paper outlining a new method for identifying selective protease substrates by phage display is finally out. Nice work from @mbarniolx.bsky.social. pubs.acs.org/doi/full/10....
- Our latest work developing AND-gate probes for imaging caspase-1 mediated inflammation is out. Very productive collaboration with Merck & Co. in South San Francisco. #chembio. www.biorxiv.org/content/10.1...
- Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work from @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. #chembio link.springer.com/article/10.1...
- The phase IIb results from the multi center trail of our cathepsin probe (VGT-309/abenacianine) are out. The probe met its endpoints and resulted in significant clinical events in 45% of patients. Great work by Vergent Biosciences and Dr. Sunil Singhal (UPenn). www.vergentbio.com/press-releas...
- Check out the nice News and Views article about our work from lead author @sijiewang.bsky.social using phage display to find covalent inhibitors of protein-protein interactions. #ChemBio www.nature.com/articles/s41...
- Reposted by Matt BogyoHello Community! Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)
- If you are interested in lipids in bacteria, check out this awesome new review written by my talented student Alyssa Carter, super postdoc Emily Woods and me. #chembio www.sciencedirect.com/science/arti...
- Great visit to Melbourne Uni to give a talk and visit with my former PhD student Laura Edgington-Mitchell and her lab.
- Had a great time at #ABPP2025! Great to see so many former lab members and their students and postdocs. Awesome venue and program. Looking forward to ABPP2027 in Leiden and then Ben Cravatt and I will try to bring it to California!
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- Reposted by Matt BogyoNIH is the best investment there is. www.forbes.com/sites/michae...
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- Another big publication from @sijiewang.bsky.social this week. Check out our efforts to use mRNA display to screen for covalent binding inhibitors of Staphylococcus aureus serine hydrolases. pubs.acs.org/articlesonre...
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- Cool work. Check it out.
- Amazing work by @sijiewang.bsky.social and our collaborators is out in JACS today. Interested in covalent inhibitors of protein-protein interactions? Check it out. pubs.acs.org/doi/10.1021/...
- Cool optical illusion. This is just two circles.
- Interesting article about the impact of the indirect rate cut proposed for NIH grants. Every state in the US has to hope this doesn’t happen. The impact on medical research AND the economy is potentially huge. All to save a fraction of a percent of the federal budget. www.nytimes.com/interactive/...
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- Cool example of covalent labeling of RNA. Love to see more examples of binding-induced reaction of electrophiles. www.nature.com/articles/s41...
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- Reposted by Matt Bogyo🅲🅾🅾🅻 🆃🅴🅲🅷🅽🅾🅻🅾🅶🆈 “Bacterial-MERFISH” provides ~1000-fold volumetric expansion of individual cells, charts gene expression in hundreds of thousands of cells, deciphering bacterial single-cell heterogeneity, intracellular transcriptome organization, and bacterial adaptation to µm-scale niches in vivo
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- Cool paper identifying covalent fragments that target splicing in T cells. Nice use of scout fragments and ABPP as well. www.cell.com/cell-chemica...
- Yes! Less is more on slides. Why do people put 4 slides on one? That is why I never set slide number limits for flash talks.
- Exciting times for our optical probe for image guided cancer surgery. Just got fast tract status at FDA for the multi-center phase II trial. www.businesswire.com/news/home/20...
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- Excited to report our studies that identified a new serine protease secreted by the gut microbe Bacteroides fragilis that regulates pain and inflammation through PAR2 activation. #ChemBio. Check it out!https://www.biorxiv.org/content/10.1101/2025.01.15.633241v1
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- First real post on @bsky.app! Check out our latest work identifying covalent fragments as inhibitors of the Fph serine hydrolases in S. aureus. Great work from Tulsi Upadhyay and our many collaborators. www.researchsquare.com/article/rs-5...
- These serine hydrolases are unique to Staphylococcus bacteria and we think play important roles in mobilization of lipids for processes such as biofilm formation. These new compounds will help us to further dissect their functions.
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