Mathias V. Schmidt
Unraveling the molecular basis of stress resilience | Group leader at MPI of Psychiatry | Secretary General Elect of FENS | Editor-in-Chief Neurobiology of Stress
- I’m thrilled to share our latest preprint from the lab, now available on BioRxiv! We investigated how early life adversity (ELA) shapes the adult brain, and the results are a stark reminder that sex isn't just a variable but leads to fundamentally different stress-induced mechanistic consequences
- By combining advanced behavioral phenotyping with whole-brain c-Fos mapping, manganese-enhanced MRI, and transcriptomics in mouse models, we found that developmental stress often has opposite neurobiological effects in males vs. females.
- Check out the full study here: doi.org/10.64898/202... Kudos to the fantastic team, especially lead author Sowmya Narayan and our incredible collaborators.
- To truly understand the neurobiological basis of complex behaviors - the real 𝐦𝐞𝐚𝐧𝐢𝐧𝐠 𝐨𝐟 𝐥𝐢𝐟𝐞, 𝐭𝐡𝐞 𝐮𝐧𝐢𝐯𝐞𝐫𝐬𝐞, 𝐚𝐧𝐝 𝐞𝐯𝐞𝐫𝐲𝐭𝐡𝐢𝐧𝐠 - we must overcome the limitations of traditional, short-term behavioral tests.
- Check out our new paper in Neuroscience & Biobehavioral Reviews: "𝑳𝒐𝒏𝒈-𝒕𝒆𝒓𝒎 𝒅𝒆𝒆𝒑 𝒑𝒉𝒆𝒏𝒐𝒕𝒚𝒑𝒊𝒏𝒈 𝒐𝒇 𝒃𝒆𝒉𝒂𝒗𝒊𝒐𝒓𝒂𝒍 𝒕𝒓𝒂𝒊𝒕𝒔 𝒊𝒏 𝒎𝒊𝒄𝒆 𝒖𝒔𝒊𝒏𝒈 𝒉𝒐𝒎𝒆𝒄𝒂𝒈𝒆 𝒎𝒐𝒏𝒊𝒕𝒐𝒓𝒊𝒏𝒈" This paper is your essential 𝐇𝐢𝐭𝐜𝐡𝐡𝐢𝐤𝐞𝐫'𝐬 𝐆𝐮𝐢𝐝𝐞 to achieving unprecedented insight into complex rodent behavior. www.sciencedirect.com/science/arti...
- We provide: - A standardized workflow for long-term home-cage monitoring in mice. - A practical guidance on experimental setups for 24-hour recordings. - A comparison of contrast- vs. ML-based tracking tools, with pros, cons, and use-cases .. and much more!
- This is the path to robust, translational data. 𝐃𝐨𝐧'𝐭 𝐏𝐚𝐧𝐢𝐜! Read the full guide and join the shift to deep phenotyping. Thanks to all co-authors and the incredible teamwork including @benjurek.bsky.social, Patrick Schlegel, @london-k-aman.bsky.social, Bartosz Zglinicki and @mikeyslezak.bsky.social
- Interesting talk by @kgoepfrich.bsky.social on RNA design and synthetic cells.
- Reposted by Mathias V. Schmidt🚨Open position at #FENS! 💭Do you want to help strengthen the voice of #neuroscience? Apply for the Advocacy and Engagement Internship at FENS! 🗓️ The deadline for applications is 31 October! 👉 loom.ly/2Qy18y8
- Reposted by Mathias V. SchmidtVery happy to share our new paper in Biological Psychiatry, showing that Urolithin A reverses high anxiety by repairing mitochondrial function in the nucleus accumbens. Big kudos to first co-authors David Mallet & Doğukan Ülgen, our amazing team, and collaborators! 🔗 Paper: doi.org/10.1016/j.bi...
- Reposted by Mathias V. SchmidtLatest lab preprint! Astrocytes are a brain cell type vulnerable to the effects of stress and the development of psychiatric-like phenotypes in animals, yet how this translates to humans is unclear... so we dived in: www.biorxiv.org/content/10.1...
- Important initiative 👇
- Ready for some really hot 🔥🥵 data on stress and trauma effects across the life span, join us at the 17:30 symposium @ebbsociety.bsky.social with @biancasilvalab.bsky.social.
- Reposted by Mathias V. SchmidtThe heat won’t stop the energy — science (and fans!) in full swing! 🔆🪭💪 #EBBS2025
- In Bordeaux for the #EBBS meeting. Looking forward to 4 exciting days of science
- Reposted by Mathias V. Schmidt🚨 NEW PAPER 🚨 Thrilled to share our latest work in "The Neurobiology of Stress" where we highlight the intricate roles of neuropeptides and neurosteroids in psychiatric disorders, & how new technologies can answer old questions about these important signallers. sciencedirect.com/science/arti...
- Reposted by Mathias V. SchmidtThe Be Open about Animal Research Day is starting now! Show your support and share on #BOARD25
- Reposted by Mathias V. Schmidt🎉It's happening - The Neurobiology of Grief International Network (NOGIN) comes to Europe! We are happy to host NOGIN from Sept 17-19 in Regensburg/DE. Registration is already open, seats are strictly limited to 100 participants. More information here: www.neurobiologyofgrief.org/events
- Excellent review by @talliezee.bsky.social and Matthew T. Birnie on the neurobiological mechanisms underlying the consequences of early life adversity. Highly recommended! www.cell.com/neuron/fullt...
- Reposted by Mathias V. SchmidtChildhood adversity as a risk factor for autoimmune disease: A systematic review and meta-analysis with implications for psychiatry www.sciencedirect.com/science/arti...
- Read about our recent discoveries on mechanisms that can drive resilience in females. www.psych.mpg.de/2949097/news...
- Reposted by Mathias V. SchmidtThe Peter Seeburg Integrative Neuroscience Prize honors groundbreaking work that bridges molecular & systems neuroscience to advance our understanding of cognition, emotion, memory, & decision-making. 🔬 Celebrate bold science. Nominate now. #Neuroscience #BrainResearch www.sfn.org/careers/awar...
- Reposted by Mathias V. SchmidtIntergenerational Effects of Stress - A Focus on Learning and Memory doi.org/10.1007/7854...
- Reposted by Mathias V. SchmidtWe're using a lab TikTok account to try and get the message out about why science is important. The latest post from @neurani.bsky.social and @g-lia-lcells.bsky.social with footage from Hunter Sowards lab visit www.tiktok.com/t/ZP82fpRCA/
- New paper: We show that especially female mice benefit from moderate early life adversity under stressful situations in adulthood. This pro-resilient effect requires the psychiatric risk factor FKBP51, which turns out to be also required for adaptive stress responses. www.nature.com/articles/s41...
- Our data especially highlight the importance of studying sex differences in how individuals cope with stress.
- Thanks to all the co-authors and collaborators! I also want to point out the important contribution of our transgenic (not transgender) mice to this study.
- Reposted by Mathias V. SchmidtMaternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis www.nature.com/articles/s41...
- Reposted by Mathias V. Schmidt🚨🧠 New paper alert: Stress alters neuronal balance in the developing brain 🧠🚨 Our latest study in @science.orgAdvances explores how glucocorticoid exposure—a key environmental risk factor—shapes early human brain development using #organoids. @mpi-psychiatry.bsky.social @drcricru.bsky.social 🧵👇
- Reposted by Mathias V. Schmidt[This post could not be retrieved]
- Very interesting paper on social behavior analysis 👇🏻
- Excited to present the latest from the lab out today in Cell www.cell.com/cell/fulltex.... See Thread! 1/8
- European Neuroscience Societies stand up for science to support our U.S. colleagues 💪🏻
- 📣 Science matters! #FENS and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬 🔗 Read the full statement: loom.ly/cn7vJR4 #sciencematters #standupforscience #sciencenotsilence #scienceforall
- Reposted by Mathias V. SchmidtA new initiative to connect #stress and #resilience researchers around the world. A global platform, needed more than ever in these times: gsr-net.org @gsrnet.bsky.social Resources to learn, teach, find labs, methods, conferences, workshops, jobs. Benefits for early-career researchers. 1/3
- Reposted by Mathias V. Schmidt🚨📃New Wassum Lab Paper📃🚨 Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇 www.nature.com/articles/s41... Free full text: rdcu.be/eaxEv
- Reposted by Mathias V. SchmidtRemember, EuropePMC is actually better than #PubMed because it includes ALL preprints in search results, not just those including NIH-funded research. europepmc.org
- The systematic undermining of science by the US administration is absolutely horrifying. The global science community needs to stand up for science and support our US colleagues in this time of crisis.
- Reposted by Mathias V. SchmidtSo excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳 Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI www.nature.com/articles/s41...
- Reposted by Mathias V. SchmidtReviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents www.science.org/doi/10.1126/...
- Reposted by Mathias V. Schmidt🧠Using #organoids, @le-and-er.bsky.social and his colleagues found that #glucocorticoids, often prescribed before premature delivery, alter the neuronal balance in the developing brain. 🥳 Check out his summary below! 🧪 #neuroskyence #PsychSciSky
- 🚨🧠 New paper alert: Stress alters neuronal balance in the developing brain 🧠🚨 Our latest study in @science.orgAdvances explores how glucocorticoid exposure—a key environmental risk factor—shapes early human brain development using #organoids. @mpi-psychiatry.bsky.social @drcricru.bsky.social 🧵👇
- Reposted by Mathias V. SchmidtReally awesome work here 👇🏼👇🏼👇🏼
- 🚨📃New Wassum Lab Paper📃🚨 Out today, @jackiegio.bsky.social discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇 www.nature.com/articles/s41... Free full text: rdcu.be/eaxEv
- Welcome @mpi-psychiatry.bsky.social to Bluesky. Follow for all news around psychiatric disorders, stress and more. 🧠🧪
- Reposted by Mathias V. SchmidtIt turns out that the environment & exposone and how you live as well as #genetics influence health #lifespan and #Aging #genetics @naturemedicine.bsky.social www.nature.com/articles/s41...
- Reposted by Mathias V. SchmidtCheck out this cool study by the @markcembrowski.bsky.social lab! They describe a new hippocampus cell population that responds to novel stimuli. But hold on to your seat: they don't if the object is presented again. Even 100 days later! When the behavioral memory has long faded!! 🤯🤯😱🤩
- Reposted by Mathias V. Schmidt1/4 I am very pleased to share this new manuscript, “A crucial role for the cortical amygdala in shaping social encounters”, led by 2 spectacular postdocs, Dr. Tony Aubry who is on the job market, and coauthor @neuromanonyc.bsky.social Read it here: www.nature.com/articles/s41...
- Reposted by Mathias V. SchmidtExcited to share Laila’s @lailaouldibbat.bsky.social first first-author paper & the very first “metabolic” paper from the lab just published @ Hormones & Behavior: "The role of ovarian hormone dynamics in metabolic phenotype and gene expression in female mice" www.sciencedirect.com/science/arti...
- Reposted by Mathias V. SchmidtDespite advancements in markerless multi-animal pose #tracking tools, overcoming occlusion & crowding remains a challenge. This study develops a 2-step method, vmTracking, that enables accurate pose tracking of multiple animals in crowded environments🧪 @plosbiology.org plos.io/4k4tFWa
- Reposted by Mathias V. SchmidtIlluminating the impact of stress: in vivo approaches to track stress-related neural adaptations www.sciencedirect.com/science/arti...
- Reposted by Mathias V. SchmidtThere are (pico)tons of estrogen in MALE hippocampus! comparable to female levels. What does the female sex hormone do a in male memory hub? 🧪🧠A >2 yr effort to measure E2 by @neurohoke.bsky.social🙏 🙏 to @kiransoma.bsky.social. Stay tuned! #Neuroskyence #NeurobiologyofStress @thebalelab.bsky.social
- Reposted by Mathias V. SchmidtVersion of Record of our work at @elife.bsky.social has been published! Super proud of this one after all the hard work of the lab seeing it to the end. Make sure to click through figure supplements as there is so much good stuff in there - sex differences, etc. elifesciences.org/articles/99988
- Reposted by Mathias V. SchmidtI am excited to share our latest paper @Nature where we construct a hi-res spatial map of the human hypothalamus, the brain region central in appetite control. It is a collaboration between @IMS_MRL @Cambridge_Uni & @MPI_Metabolism www.nature.com/articles/s41...
- Great resource for all stress researchers! Check it out🧪🧠😍
- The website of the Global Stress and Resilience Network is officially released! Worth exploring and contributing! 👉 gsr-net.org
- Reposted by Mathias V. SchmidtReminder for Wednesday 👇👇
- Reposted by Mathias V. SchmidtYay! PANS is on #bluesky! Welcome to the party. A fabulous community of cool neuroendocrinologists. 😎👏🏻 @infneuroendo.bsky.social @bsneuroendo.bsky.social @sneuroendo.bsky.social @endocrinesociety.bsky.social @paneuroendo.bsky.social
- Reposted by Mathias V. SchmidtThe use of glucagon-like peptide 1 receptor agonists (GLP-1RAs) may be associated with a broad spectrum of health effects, including decreased risk for 42 health outcomes and increased risk of 19 health outcomes, according to a study in Nature Medicine. go.nature.com/3ClpHHx #Medsky 🧪
- Reposted by Mathias V. SchmidtDespite the widespread use of GLP-1 analogs, a significant gap remains: most preclinical and clinical studies fail to consistently include or analyze sex-disaggregated data. This oversight is critical, as women now represent over 75% of young patients using these therapeutics. #Ozempic #Wegovy 🧪
- Reposted by Mathias V. SchmidtNew review from the lab on forgetting, and a brief thread (1/4): www.sciencedirect.com/science/arti...
- Reposted by Mathias V. SchmidtPaper of the week: "Dorsal BNST GABA neurons are necessary for chronic unpredictable stress-induced depressive behaviors in adolescent male mice." Activation induces depressive-like behaviours, inhibition alleviates CUS-induced depressive-like behaviours. www.sciencedirect.com/science/arti...
- Reposted by Mathias V. SchmidtHope you'll forgive a quick thread as I take over as the new EiC of @elife.bsky.social
- Reposted by Mathias V. Schmidt
- Reposted by Mathias V. SchmidtThe 13th International Meeting of Steroids and the Nervous System is happening! Feb 2026 - There is an open call for symposia. It's one of my fav meetings - the food, wine, cheese, chocolate and science!! Deadline is March 18, 2025.
- Reposted by Mathias V. SchmidtI’m thrilled to share our preprint presenting MORSE: a new way to simultaneously & quantitatively track patterns of neuromodulators/neuropeptides in vitro & in vivo using spatially multiplexed 3D imaging of 10+ green optical sensors on a microendoscope biorxiv.org/content/10.1101/2025.01.26.634931v1
- Reposted by Mathias V. SchmidtThrilled to share my perspective in "The Transmitter" @thetransmitter.bsky.social on how to study the influence of "sex" and "gender" in the brain in a scientifically accurate and socially responsible manner: "Revisiting sex and gender in the brain" www.thetransmitter.org/sex-differen...
- Reposted by Mathias V. Schmidt📣📣📣 ✅ Are you a senior PhD student in neuroscience? 🧠 ✅ Looking for career development opportunities?💼 ✅ Want to visit NYC in spring?🗽 ✅ Considering a postdoc at NYU? 🥼 ✅Apply for CoNNExINS! wp.nyu.edu/connexins/ Please RT!
- Reposted by Mathias V. SchmidtArtificial intelligence in drug development - New timely review in Nature Medicine www.nature.com/articles/s41...
- Reposted by Mathias V. SchmidtMapping the effectiveness and risks of GLP-1 receptor agonists “Compared to usual care, GLP-1RA use was associated with a reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimer’s disease and dementia” www.nature.com/articles/s41...
- Reposted by Mathias V. SchmidtLove it! 🧪🧠 Transfer your community, followers,idols from the blue bird to the blue sky via Sky Follower Bridge! What a 😎 tool. @superkash.bsky.social @cate-cholamine.bsky.social #NeurobiologyofStress @svmahler.bsky.social @martinowk.bsky.social
- Reposted by Mathias V. SchmidtThe DREAM implant is a novel design for chronic electrophysiology in mice that is lightweight, adaptable, and cost-effective. @ZeroNoiseLab @3DNeuro @DondersInstitute Read about it in this week's post on OpenBehavior: edspace.american.edu/openbehavior...
- Reposted by Mathias V. SchmidtStayed connected with SfN on BlueSky! 🧠 Follow @sfn.org for SfN news & updates, @brainfactsorg.bsky.social for neuroscience education, @sfnjournals.bsky.social for the latest research from JNeurosci & eNeuro, and @neuronline.sfn.org for career resources & community discussions. #Neurosky
- Reposted by Mathias V. SchmidtBecome an active part of your society: @ebbsociety.bsky.social is looking for two ordinary committee members and secretary More information can be found here: www.ebbs-science.org/elections
- Reposted by Mathias V. SchmidtNew research reveals that like humans and other social mammals, cats tend to mirror the faces of their companions—a key component to getting along. scim.ag/3PBDsom
- Reposted by Mathias V. Schmidt🚨 Both registration and abstract submission are now OPEN for the #WASAD2025 Congress, themed "Uncertainty in Times of Change: A Lifecourse Approach to Stress and Anxiety" 📅 October 23–25, 2025 📍 Munich, Germany. Register today: wasad2025.org #AcademicConference #MentalHealthResearch
