Laura Lorenzo Orts
New PI @IMB in Mainz, Germany. Combining in vitro and in vivo approaches to study maternal mRNA regulation in 🐟 embryos.
- Reposted by Laura Lorenzo OrtsPlease share! My group at @zmbp-tuebingen.bsky.social is offering a post-doctoral position (4 years). We look for a structural biologist with experience in Cryo-EM/Cryo-ET to investigate the mechanisms of host invasion by pathogenic fungi. Deadline February 28th! uni-tuebingen.de/universitaet...
- Reposted by Laura Lorenzo OrtsNow out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake! rdcu.be/e1bBW
- Reposted by Laura Lorenzo OrtsFormation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells! Read our paper @cp-cell.bsky.social! ❕Publication: doi.org/10.1016/j.ce... ❕Press Release: www.biochem.mpg.de/en/pressroom @uoftmedicine.bsky.social @erc.europa.eu #UPSmeetMet
- Reposted by Laura Lorenzo OrtsNew findings in Science offer insight into why some embryos fail to develop past zygotic genome activation, pointing to an unexpected root of human infertility. Learn more: scim.ag/46cc4WI
- Reposted by Laura Lorenzo OrtsI’m happy to share the main result of my PhD, which you can find on bioRxiv www.biorxiv.org/content/10.6.... If you are interested in learning about a new way to perform DNA-PAINT multiplexing, which we call Combi-PAINT, or if you are interested in the study of mRNA conformation, keep reading! 1/10
- Reposted by Laura Lorenzo Orts🐟 Exciting News! 🐟 1st German Fish Model Research Meeting : 🔗 Submit your abstract and register today: www.germanfishmeeting.org 📅 When: September 16–18, 2026 📍 Where: Center for Organismal Studies, Heidelberg, Germany #germanfishmeeting2026 #fish #research #zebrafish #science
- Reposted by Laura Lorenzo OrtsExcited to share our new paper! We developed a method to visualize proteasomal degradation at the single–molecule level in live cells, enabling us to dissect distinct modes of substrate engagement, probe co-factor dependence, and study proteasome–ribosome collisions. www.biorxiv.org/content/10.6...
- Reposted by Laura Lorenzo OrtsNew lab paper!! We develop a technology for real-time, single-molecule visualization of proteasomal substrate degradation in cells. We find that the site of substrate engagement by the proteasome determines decay kinetics, efficiency and co-factor requirement. www.biorxiv.org/content/10.6...
- Reposted by Laura Lorenzo OrtsDiscuss #RNA 3' ends and their regulation at the EMBO Workshop "RNA 3' ends and beyond" in #Oxford, United Kingdom, 7–11 September 2026. Deadline: 4 May 2026 meetings.embo.org/event/26-rna3 #EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪
- Reposted by Laura Lorenzo OrtsAlphaFold protein interaction modeling tutorial and workshop thenode.biologists.com/https-www-yo...
- Reposted by Laura Lorenzo Ortscheck this beauty from @reneketting.bsky.social @koenig-lab.bsky.social and co www.biorxiv.org/content/10.6...
- Reposted by Laura Lorenzo Orts🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org
- Reposted by Laura Lorenzo OrtsThe (Yoav) Voichek lab has opened its gates at the Weizmann Institute, and is actively recruiting students and researchers at all levels - come explore gene regulation and computational genomics in a fun, friendly sprouting lab 🤗🥼⚗️🧪 www.weizmann.ac.il/plants/voichek
- All the best, Juan Carlos! Nos vemos por Alemania 😊
- With the new year, is my time to say bye to @gmivienna.bsky.social as I move to @zmbp-tuebingen.bsky.social in Tuebingen. I will start my solo Group Leader career as a Emmy Norther fellow. Thanks to everyone that helped on the way. I will be advertising PhD and Postdoc positions soon, stay tuned!
- Reposted by Laura Lorenzo OrtsHappy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com www.nature.com/articles/s41... Below a short🧵 with the key findings!
- Reposted by Laura Lorenzo OrtsHappy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5. Thanks to all collaborators, we could not have done it without you 🤩 rdcu.be/eWMfA
- Reposted by Laura Lorenzo OrtsWhat a way to start the new year with one more submission to BioRxiv. This one is on how GTSF-1 enable RdRP activity in nematodes (for Piwi aficionados: correct, it does not affect Piwi😊) www.biorxiv.org/content/10.6...
- Reposted by Laura Lorenzo OrtsIf you want to become an expert in #zebrafish research, apply for the 2026 Zebrafish Development & Genetics course! You will be working in small groups taught by leaders in the field, which can be a transformative experience! Application deadline: March 2 www.mbl.edu/education/ad...
- Reposted by Laura Lorenzo OrtsLooking for a great first read for 2026? Look no further: Fantastic work spearheaded by my courageous colleague @changweiyu.bsky.social, with surprising findings not only for small RNA but also for exosome and gene expression aficionados
- Reposted by Laura Lorenzo OrtsSignalling by ubiquitination is... ubiquitous ! It regulates virtually all cellular processes in eukaryotes. Bacteria do not encode a functional ubiquitin system, yet some can manipulate ubiquitin signalling in their host. This example 𝐛𝐫𝐞𝐚𝐤𝐬 𝐚𝐥𝐥 𝐫𝐮𝐥𝐞𝐬 ! 1/3
- Reposted by Laura Lorenzo OrtsDo transcriptional activators work on any promoter? Our data says no. 🙅♂️ Despite driving ~2/3 of mammalian genes, CpG island (CGI) promoters have remained a puzzle. We identified >50 activators that are exclusively compatible with this promoter class. 🧬
- Reposted by Laura Lorenzo OrtsActivator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)
- Reposted by Laura Lorenzo OrtsWhat is actually a high-risk, high-gain project proposal? Great to hear the answer directly from the ERC president Maria Leptin. 🎧 nightscience.buzzsprout.com/1744020/epis... Night Science (@nightsciencepod.bsky.social) is simply an amazing podcast for scientists! #ERC #NightScience #GrantWriting
- Reposted by Laura Lorenzo Orts1/ Can #Axolotls teach us new things about #HeartRegeneration? A great collaboration between Elly Tanaka and Miguel Torres labs. We’re happy to share our new work in which we ask how axolotls regenerate their hearts and could they help mammals with that? doi.org/10.64898/202...
- Reposted by Laura Lorenzo OrtsA 1.25 A!!! cryo EM structure of rubisco.
- Reposted by Laura Lorenzo OrtsVery happy to share my postdoc work (on preprint), where we try to understand a long-standing transcription-silencing paradox, and uncovered a hidden RNA decay arm of nuclear piRNA pathway, see detailed threads quoted from @juliusbrennecke.bsky.social
- Reposted by Laura Lorenzo OrtsIntrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.
- RNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing biorxiv.org/content/10.64898/20…
- Reposted by Laura Lorenzo OrtsHappy to share two BioRxiv manuscripts from our lab. One on genetic Argonaute interaction and unexpected non-correlation between small RNAs and their targets: doi.org/10.64898/202... The second on IDR processing and IDR-mediated Argonaute loading control: doi.org/10.64898/202... Merry Xmas😊
- Reposted by Laura Lorenzo OrtsFinally! A working protocol for the RT sperm storage 🐟 Working link: bio-protocol.org/en/bpdetail?...
- Reposted by Laura Lorenzo OrtsMy "News & views" was published today @natmethods.nature.com Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left... www.nature.com/articles/s41...
- Reposted by Laura Lorenzo OrtsRNA decay via the nuclear exosome is essential for piwi-mediated transposon silencing biorxiv.org/content/10.64898/20…
- Reposted by Laura Lorenzo OrtsVaults. They are cell biology's greatest puzzle! This preprint from Martin Beck's lab shows them docked on ER membranes with a ribosome inside. What on earth is going on there?? #CellBiology #WTFology www.biorxiv.org/content/10.6...
- As 2025 comes to an end, it’s time for me to say good bye to my postdoc home during the past 6 years – the Pauli lab @pauligroup.bsky.social @impvienna.bsky.social
- A big THANK YOU to the entire lab, both my colleagues and Andi. After 6 years, you’ve become like family, and I’ll miss you greatly. Thanks for the support, the freedom to develop my ideas, and all the fun moments!
- Although I am sad to be leaving, I am also excited to start my own group at @imbmainz.bsky.social in February 2026. There, I will be exploring the regulation of translation in early embryonic development using both in vivo and biochemical approaches.
- I’m deeply thankful to @imbmainz.bsky.social for trusting me and to all my past mentors and colleagues who supported me throughout my career, including @pauligroup.bsky.social during my postdoc and @structplantbio.bsky.social during my PhD.
- Reposted by Laura Lorenzo Ortsso many grand gestures welcoming US researchers - neglecting the fact that funding in Canada, Australia, Europe and China is already fiercly competitive. This is not the solution. #standupforscience
- Reposted by Laura Lorenzo OrtsI’m thrilled to share that our project, FATERNA, has been awarded an ERC Consolidator Grant! We’ll explore the mechanisms of pre-mRNA fate control. Huge thanks go to our awesome research team, colleagues, and the fantastic support from @impvienna.bsky.social & @viennabiocenter.bsky.social CP.
- The results of the ERC Consolidator Grant call have been announced! 📣 349 researchers have been selected for funding. Congratulations to all! #ERCCogG! 👉 buff.ly/uu62uFV #FrontierResearch #EUfunded #HorizonEurope @scienceinnovation.ec.europa.eu
- Reposted by Laura Lorenzo OrtsPlease RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...
- Reposted by Laura Lorenzo OrtsIf I saw a "murder hornet," I'd be running in the other direction. But these wee frogs think they're tasty snacks—even though they get stung repeatedly while consuming them. That story and more from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪
- Reposted by Laura Lorenzo Orts📢 We have multiple open PhD positions to study bacterial immune systems using cutting-edge cryo-EM, microbiology, and biochemistry in our group! Join us and uncover how bacterial defenses eliminate predators and engineer next-gen biotech tools. 🔥 Apply by Jan 8, 2026 Details: phd.pages.ista.ac.at
- Reposted by Laura Lorenzo OrtsGlad to have this finally published: www.sciencedirect.com/science/arti... lots of new data since the #preprint. If you are into selective #autophagy, #evolution, #proteostasis Please have a look!
- Reposted by Laura Lorenzo OrtsOur latest collaboration with Fiedler lab @fmp-berlin.de and Panse labs UZH out on @biorxiv-plants.bsky.social. Using bead-adsorbed, non-hydrolyzable inositol pyrophosphate (PP-InsP) analogs, we isolated many putative PP-InsP-binding proteins from Arabidopsis. www.biorxiv.org/content/10.1... (1/6)
- Reposted by Laura Lorenzo OrtsYour periodic reminder that science is not done by a few selected "stars scientists". Science is done by hundred of thousands. Siloed money mean a few flashy discoveries and a lot of waste. Want to change things? Make funding accessible and stop funding calls with less than 2% success rate.
- · #AcademicSky · The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.
- Reposted by Laura Lorenzo OrtsThis this this
- Reposted by Laura Lorenzo OrtsHow does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
- Reposted by Laura Lorenzo Orts... and we would love to see you ALL - working with ANY fish model - join us in Vienna for www.ezm2026.org, the biggest fish meeting in 2026! We plan to have a special session 'beyond zebrafish' and would love to include talks representing other fish systems across all sessions. Pls spread the word!
- Removed by author.The #zebrafish community is more than just Danio rerio! In our Slack Pro tankspace, we have shoal members that work with more than 27 different species including: Danionella dracula & cerebrum, Xiphophorus, Spotted gar, Medaka, African cichlid, Cavefish, Killifish, Stickleback, Sharks and more! 🐟🐠🦈🧪
- Reposted by Laura Lorenzo Ortsanybody looking for exciting opportunities in RNA research, with the goal to use and learn state of the art thinking and experimenting: here is a good starting point. Ulrich is an outstanding scientist and natural leader. 👇👇👇👇
- Lastly, I’m excited to join @imbmainz.bsky.social in 2026 to start my own lab. We'll explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. tinyurl.com/y4x29ctt Thanks for reading! 20/20
- Reposted by Laura Lorenzo OrtsFinally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
- Reposted by Laura Lorenzo OrtsWhen people celebrate the individual genius of folks in science, they should also mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)
- Reposted by Laura Lorenzo Ortsjust in time for the opening of the @hohmannulrich.bsky.social group at @imbmainz.bsky.social what started as a project on how cells export piRNA precursors, ended up as a tour de force in mRNA export. truly wonderful collaboration with @plaschkalab.bsky.social at the @viennabiocenter.bsky.social
- New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at @imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
- 👇 Very sad. Science moves forward through questioning and uncertainty. Claims later proven wrong can only increase society’s distrust in science. We, scientists, should be able to acknowledge gaps without fearing a loss of funding or the impact on our publications...
- Researchers use less and less hedges (may, might, perhaps, probably ...) in their papers. Or in other words papers are becoming more like biblical texts. link.springer.com/article/10.1...
- Reposted by Laura Lorenzo OrtsNew paper alert! Scientists in Julius Brennecke’s lab at IMBA and Clemens Plaschka’s lab at @impvienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: imba.science/3Xl2hJ3
- Reposted by Laura Lorenzo OrtsNew paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at @imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys
- Reposted by Laura Lorenzo Orts🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social www.nature.com/articles/s41...
- Reposted by Laura Lorenzo OrtsSuper cool! Again, how p-bodies control gene expression in cell fate transitions
- 1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
