Delighted to be part of this work from the Lopes lab identifying nucleoplasmic Lamin A/C as a key regulator of replication fork plasticity, acting via de novo heterochromatin and ADP-ribosylation to control RECQ1-mediated fork restart. Now in Nature Comm. 🎉Special efforts:
@joannapaulson.bsky.socialNucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels
Nature Communications - Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C – best...
