Lopes_Lab: Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social . rdcu.be/eVrxX

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Lopes_Lab lopeslab.bsky.social
Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social . rdcu.be/eVrxX
Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels

Nature Communications - Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C – best...

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Dec 19, 2025 12:44
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Lopes_Lab lopeslab.bsky.social · Dec 19, 2025
We link replication fork plasticity to another important player of nuclear architecture, i.e. Lamin A/C, by showing that its nucleoplasmic fraction modulates heterochromatic marks and ADP ribosylation levels at replication factories, thereby controlling RECQ1-dependent restart of reversed forks!

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