Grosshans Lab
Studying mechanisms of developmental clocks and timers at the Friedrich Miescher Institute for Biomedical Research, Basel.
- Reposted by Grosshans LabNow out in @currentbiology.bsky.social: neuroscientists in the lab of @felsenberg.bsky.social found that in fruit flies, re-tasting a sugar reward can weaken past memories, pointing to new ways to safely update harmful ones. www.fmi.ch/news-events/...
- Reposted by Grosshans LabVery thankful for this thoughtful dispatch by @shaisrael.bsky.social sky.social and Moshe Parnas about our work. Learning and memory: Forgetting to remember: Current Biology www.cell.com/current-biol...
- Now out in @currentbiology.bsky.social: neuroscientists in the lab of @felsenberg.bsky.social found that in fruit flies, re-tasting a sugar reward can weaken past memories, pointing to new ways to safely update harmful ones. www.fmi.ch/news-events/...
- Reposted by Grosshans LabOur annual brochure “Year in Review” is out now! It highlights the FMI’s key scientific publications, major events, and facts & figures from 2025, a year that marked our 55th anniversary. www.fmi.ch/news-events/...
- Reposted by Grosshans LabProf. Fiona Doetsch has been awarded the 2026 Louis-Jeantet Prize for Medicine! Her discoveries reveal how neural stem cells support lifelong brain plasticity and repair. 🧠 Read more: www.biozentrum.unibas.ch/news/detail/...
- RNA-binding proteins function through network effects, coordinately binding and weakly regulating many transcripts – or don’t they? Read our new preprint on how LIN28 controls developmental timing through only two targets, one mRNA, one miRNA. doi.org/10.64898/202...
- Please repost - position of Head of Student & Postdoc Affairs available at our Institute in the heart of Europe (Basel, Switzerland) 👇
- 📢 Please help spread the word: We’re hiring a Head of Student & Postdoc Affairs to coordinate our international PhD program, provide guidance & career counseling, lead training programs, collaborate on EDI initiatives, and manage alumni relations. Apply at www.fmi.ch/education-ca...
- Reposted by Grosshans LabRead this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas) www.pnas.org/doi/10.1073/...
- Reposted by Grosshans LabSwitzerland is joining Horizon Europe! We are uniting two research powerhouses. For cutting-edge innovation that will boost our energy security, digital transformation, health and so much more. Today is a good day for science, and for our EU-Switzerland partnership.
- Reposted by Grosshans LabAnd we have another open position, this time with a focus on Genome Biology! Join a great community in Vienna to bring your research to the next level!
- 📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
- Reposted by Grosshans LabNow in @embojournal.org: Researchers in @labgrosshans.bsky.social & UCSC found that similar molecular machineries control daily circadian rhythms & developmental timing—showing that evolution can repurpose core timing systems to coordinate both daily cycles & growth. www.fmi.ch/news-events/...
- Reposted by Grosshans LabHere is the schedule for the next TriRhena Gene Regulation Club at the FMI @fmiscience.bsky.social in Basel 🇨🇭 next week (5 Nov 2025; 14:00-18:45). Exciting topics ahead & we are looking forward to the #newPI talks by @julianeg.bsky.social (MPI) & Anupama Hemalatha (FMI). www.ie-freiburg.mpg.de/grc
- Nektarios Tavernarakis on why curiosity-driven research, not focusing on application, is fundamental to problem solving and requires government support in @emboreports.org doi.org/10.1038/s443...
- "[In C. elegans] researchers uncovered key principles of cell death and RNA interference [that] paved the way for new therapies and technologies. These breakthroughs were made not because they were sought by design, but because a few scientists, supported by public grants, followed their curiosity"
- Flying worms! www.science.org/content/arti... (And I always wondered how worm cuticular alae (= wings) got their name 😉)
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- And the next one: dx.doi.org/10.1038/s44318-025-00585-z . Super-fun collaboration with @partchlab.bsky.social & @gotworms.bsky.social to find similarities between developmental and circadian clocks – supported by @fmiscience.bsky.social Facilities and, financially, @snsf.ch and @erc.europa.eu . 1/n
- The C. elegans LIN-42 protein is orthologous to fly/mammalian PERIOD – but during development, oscillates with a 7-hr rather than a 24-hr period. It affects temporal cell identity and promotes rhythmic molting – but how, was unclear 2/n
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- And here is a layperson video summary of parts of our recent paper👇
- 🎥 FMI scientists discovered that thousands of C. elegans genes switch on and off in rhythmic patterns controlled by chromatin, revealing how gene timing shapes development & offering clues to human biological clocks. @labgrosshans.bsky.social www.youtube.com/watch?v=Dibw...
- Reposted by Grosshans Lab🎥 FMI scientists discovered that thousands of C. elegans genes switch on and off in rhythmic patterns controlled by chromatin, revealing how gene timing shapes development & offering clues to human biological clocks. @labgrosshans.bsky.social www.youtube.com/watch?v=Dibw...
- Watch Lucas' amazing artistic/musical rendition of C. elegans larval development and our work on developmental timing and molting here youtu.be/-hGHYRvw87w and read on his inspiration and challenges below
- In May, Lucas Morales represented the FMI at the @eu-life.bsky.social Science Vision Talk Contest in Brno—Eurovision for science. His live talk had surprises, but he later recorded a new version. Watch it and read his Q&A on science, career and communication: www.fmi.ch/news-events/...
- Reposted by Grosshans LabModel organisms as platforms for training scientific minds www.nature.com/articles/s41...
- PREACH! www.nature.com/articles/s41...
- Paper alert! doi.org/10.1038/s443... - "A scheduler for rhythmic gene expression". We show how 9 txn factors suffice for rhythmic gene expression of thousands of genes with any phase or amplitude in #Celegans larvae (and also look at the tissues where oscillations happen) 1/n
- This was the starting point doi.org/10.15252/msb... 1000s of "oscillating" genes, all peaking once per larval stage, but at different times. How is this broad dispersion of peak phases achieved? Perhaps a superposition of different tissues, given that the observation was with whole animal data? 2/n
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- Reposted by Grosshans Lab🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬 Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
- Thanks for highlighting - thread to follow. Mini-summary: beyond assigning oscillatory genes expression by scRNA-seq to individual cell types, we also show that chromatin opens rhythmically and that we can predict this (and gene expression) with a small set of TFs in a mathematical model.
- Here is some recommended reading 👇 (and enjoy the associated thread for clarity and the beautiful imagery 👍) Lots of different genes, oscillating in different cell types
- Reposted by Grosshans Lab🎊 Congratulations to Juliane Glaser (@julianeg.bsky.social) and Valentin Flury (@flurylab.bsky.social) on being awarded each an @erc.europa.eu Starting Grant! – #ERCStG www.ie-freiburg.mpg.de/6057908/2025...
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Super excited that our group will be supported by an ERC Starting Grant! In project "InfoFate" we will study how cells use information in dynamical, neighborhood & mechanical signals to make decisions. We'll have PhD and Postdoc positions available, please get in touch if interested!- Why do some cells become neurons and others muscle? Physicist Prof. David Brückner @davidbrueckner.bsky.social @biozentrum.unibas.ch @unibas.ch receives a prestigious #ERCStartingGrant to uncover how cells make life-shaping decisions. @erc.europa.eu www.biozentrum.unibas.ch/news/detail/...
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- Reposted by Grosshans Lab🪱 C. elegans (Nematode). Every cell counts, literally. C. elegans has a fully mapped cell lineage from egg to adult. Key for understanding cell fate specification, apoptosis, nervous system wiring, aging, and stem cell regulation. Image taken by Swagata Dey #ModelMonday
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- Very thrilled to welcome Julia as our new colleague in Multicellular Systems at @fmiscience.bsky.social !
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- Reposted by Grosshans LabThis is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
- Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
- Reposted by Grosshans LabExcited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
- Reposted by Grosshans LabWe're seeking a Research Associate in stem cell biology to join a global, interdisciplinary team investigating organoids and tissue organization. This unique role is part of a collaboration between the @priscaliberali.bsky.social lab & the @alleninstitute.org. Apply at: www.fmi.ch/education-ca...
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- We are hiring👇. Join us if you are interested in a PhD project on biological clocks that time development. Genomics, genetics, quantitative microscopy, computational analysis, ... grosshanslab.org. 2.5 weeks left to apply www.fmi.ch/education-ca... @fmiscience.bsky.social
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- Always a such satisfying moment to see one of your students defend – congratulations, Jana, great work!
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- Reposted by Grosshans LabHow do embryos ensure precise tissue patterning? It’s all about timing cell divisions! Our new preprint reveals how cell proliferation syncs with signaling oscillations to regulate precision of somite formation and growth. Check the full story: www.biorxiv.org/content/10.1...
- Reposted by Grosshans Lab🚨New preprint alert!!! We show using #Celegans that mothers control the #ribosome levels of their offspring depending on their diet. Pioneered by fantastic Sigma Pradhan (not yet on 🟦). #worms biorxiv.org/content/10.1.... 🧵
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- Reposted by Grosshans LabThe realignment of research in our group @fmiscience.bsky.social is beginning to bear fruit. Proud of our captain @merleskribbe.bsky.social and the whole team! www.sciencedirect.com/science/arti...
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- #AmericaHasSpine: Nobel Laureate @vambros.bsky.social on the Trump Administration's demolition of NIH, Science and democratic institutions:"As this Administration tries to install a totalitarian regime, we at the same moment have to resist" Feature on Swiss National Radio here: tinyurl.com/AmbrosSRF
- Reposted by Grosshans LabIf you are an enthusiastic, motivated and team-oriented life science researcher-in-spé, we are looking for you! We offer excellent science and working conditions. For more info on projects please see. Please help me spread this🙏 www.imb.de/students-pos...
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- Reposted by Grosshans LabMaking intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15) www.biorxiv.org/content/10.1...
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- Reposted by Grosshans LabPostdoc positions on nuclear RNA biology available in the Heick Jensen lab. Come join us in tiny Denmark. Interested? - then follow this link: mbg.au.dk/aktuelt/ledi...
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