Dr Karolina Farrell
Neuroscientist interested in psychiatric disorders. Research Fellow in the Institute of Neurology @uclqsion.bsky.social at UCL; previously at the Crick.
- Reposted by Dr Karolina Farrell'to treat peer review as a throughput problem is to misunderstand what is at stake. Review is not simply a production stage in the research pipeline; it is one of the few remaining spaces where the scientific community talks to itself.' 1/3
- Reposted by Dr Karolina FarrellRA job alert. We are looking for a fearless experimentalist to join our experiments on cortical neuromodulators during visually guided learning, lead by @michael-lynn.bsky.social . Opportunity to learn 2p imaging, design and conduct experiments. RT plz. Apply here: my.corehr.com/pls/uoxrecru...
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- Reposted by Dr Karolina FarrellNature research paper: Predictive coding of reward in the hippocampus go.nature.com/49mB13V
- Reposted by Dr Karolina FarrellNew preprint. We show that in addition to reward prediction errors (RPEs), dorsal striatal dopamine signals encode sensory prediction errors (SPEs), the difference between sensory prior & observed stimulus. www.biorxiv.org/content/10.6...
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- Reposted by Dr Karolina FarrellThrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41... #blueprint 1/7
- Reposted by Dr Karolina FarrellDelighted to see this finally out: rdcu.be/eO9oW We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.
- Reposted by Dr Karolina FarrellProud to have contributed to @gaiabianchini.bsky.social and @flor-iacaruso.bsky.social new paper on how the superior colliculus temporally integrates multisensory information
- Reposted by Dr Karolina FarrellHow does the brain find its way in realistic environments? 🧠 Using deep RL and neural data, we show that hippocampal-like networks support navigation, learning, and generalisation in partially observable environments—mirroring real animal behaviour. Now out: www.nature.com/articles/s41... #neuroAI
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- Reposted by Dr Karolina FarrellOut today at Neuron, our experiments show that frontal cortical representation of economic variables is jointly determined by spatial organization and downstream connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...
- Reposted by Dr Karolina FarrellIn this review, @kangjoolee.bsky.social and colleagues propose a provisional formalism, considering mechanism type, severity, and time, to map neuropsychiatric behavioral pathology to its underlying dynamic neural mechanisms to advance the development of precision treatments.
- Reposted by Dr Karolina FarrellAll-optical experiments are great but @neurorussell.bsky.social found that opsin desensitization due to cross-talk between the imaging laser and the opsin causes major issues. These can be ameleorated with long inter-stimulus intervals & short imaging doses. All here: www.biorxiv.org/content/10.1...
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- Reposted by Dr Karolina FarrellPost doc job alert 📢! Announcing a v exciting job on a Wellcome-funded project in my group at UCL, looking at auditory hallucinations... Advert here 👀: rb.gy/230w8l - deadline is end of Oct. Please apply! 1/5
- Reposted by Dr Karolina FarrellNew #job alert! Clinical research fellow / postdoc in #computationalpsychiatry at the @mpc-comppsych.bsky.social / @uclqsion.bsky.social and UCL psychiatry. We will aim to understand the computations engaged by serotonin in the treatment of depression. Please re-sky. www.ucl.ac.uk/work-at-ucl/...
- Reposted by Dr Karolina FarrellWe have a PhD project here, along with many other cool projects: "Characterising and predicting seizure onsets from longitudinal sEEG data", www.crick.ac.uk/careers-and-... with @flor-iacaruso.bsky.social (Crick), Torsten Baldeweg (UCL) and Martin Tisdall (UCL). Apply by: 14 November 2025.
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- Reposted by Dr Karolina FarrellPhenomenal. In my 10 year update of A Brief History, I make the point that in the first edition, not one disease had been successfully treated using gene therapy. Today that number is at least 7.
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- Reposted by Dr Karolina FarrellNew lab paper by @merridee.bsky.social identifying a novel role for VTA GABA neurons in behavioral flexibility GABA, but not dopamine, neuron activation correlates with behavior when cues unexpectedly shift from predicting punishment to predicting reward www.sciencedirect.com/science/arti...
- Reposted by Dr Karolina FarrellThe potential for 2 cancer drugs in combination to impact Alzheimer's disease as an outgrowth or single-cell RNA -seq, review of electronic health records from 1.4 million patients, and whittling down 1,300 potential repurposed drugs to 2. www.cell.com/cell/fulltex...
- Reposted by Dr Karolina FarrellBurnout is clinically understood as a combo of 6 factors—work overload, lack of control, insufficient rewards, breakdown in community, absence of fairness, & value conflicts—and only a fraction of it is under your control. Burnout is a systemic problem, so be kind to yourself and hard on the system.
- Reposted by Dr Karolina FarrellOur work, out at Cell, shows that the brain’s dopamine signals teach each individual a unique learning trajectory. Collaborative experiment-theory effort, led by Sam Liebana in the lab. The first experiment my lab started just shy of 6y ago & v excited to see it out: www.cell.com/cell/fulltex...
- Reposted by Dr Karolina Farrell🧠💥 Our new preprint is out! We pooled 5 RCTs on intranasal esketamine for treatment-resistant depression—and found clear sex-specific patterns in how patients respond. Read it here: www.medrxiv.org/content/10.1... #TRD #Esketamine #Neuropsychiatry #OpenScience #MentalHealth
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- Reposted by Dr Karolina FarrellYour brain doesn’t just passively track time ⏳ - it structures it. In @Science.org we show that activity in 🧠 memory circuits (LEC) drifts constantly, but makes sharp jumps at key moments, segmenting life into meaningful events. (1/2) 👉 www.science.org/doi/10.1126/...
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- Reposted by Dr Karolina FarrellNew work from my lab looking at how dopamine neurons are affected by stress and males and females! This paper comes to you through three rounds of major building construction, a pandemic, six months that we could not get TTX, some animal facility shenanigans and now is here on your internet!
- Reposted by Dr Karolina FarrellIt's officially published!! In my main postdoc work with @markplitt.bsky.social and @lgiocomo.bsky.social, we found that the hippocampus simultaneously encodes an animal's spatial position and its experience relative to reward in parallel population codes. 🧵 www.nature.com/articles/s41...
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- Reposted by Dr Karolina Farrell📢Alain Destexhe and colleagues from @neuropsi.bsky.social introduce a computational framework to study how molecular changes impact brain activity. #compneurosky #Neuroskyence www.nature.com/articles/s43...
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- Reposted by Dr Karolina FarrellWhy are animal models useful for CNS drug discovery? zendudest.substack.com/p/why-animal...
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- Reposted by Dr Karolina FarrellSharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation. rdcu.be/el18q A short thread follows for those interested. 1/n
- Reposted by Dr Karolina Farrell🚨Very excited to share a new paper from our lab in Neuron (@cp-neuron.bsky.social) on the influence of the estrous cycle on structural and functional plasticity in the hippocampus: www.sciencedirect.com/science/arti... Thread below 🧠🧪🧵:
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- Reposted by Dr Karolina Farrell🧠🧬 We still don’t know how antidepressants *actually* work. Why does depression respond to treatments as diverse as SSRIs, TCAs, electroconvulsive therapy, TMS, tianeptine, and ketamine? What do these treatments have in common? (hint: not serotonin) See our new preprint! doi.org/10.1101/2025...
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