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Johannes Pilic

johannes-pilic.bsky.social

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Postdoc at ETH Zurich in the Kleele lab. I'm interested in mitochondria, microscopy and systems biology.

Joined November 2024

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Juan C. Landoni 🔬 jclandoni.bsky.social · Nov 25, 2025
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Joachim Goedhart joachimgoedhart.bsky.social · Dec 1, 2025
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Johannes Pilic johannes-pilic.bsky.social · Oct 29, 2025
Systems biology view on mitochondrial dynamics, I like it 🤩
- bioRxiv SysBio biorxiv-sysbio.bsky.social · Oct 28, 2025
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Joachim Goedhart joachimgoedhart.bsky.social · Jul 14, 2025
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neftalycm neftalycm.bsky.social · Jun 1, 2025
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euromit-2026 euromit-2026.bsky.social · Feb 3, 2025
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Johannes Pilic johannes-pilic.bsky.social · May 14, 2025
Impairing mitochondrial fusion triggers a vicious cycle of unequal mitochondrial inheritance and failed mtDNA synthesis that rapidly depletes mtDNA: www.biorxiv.org/content/10.1...
When mitochondria fall apart: Unbalanced mitochondrial segregation triggers loss of mtDNA in the absence of mitochondrial fusion

Mitochondrial biogenesis and inheritance must be carefully regulated alongside cell division to ensure proper mitochondrial function and cell survival. The dynamics of the mitochondrial network, inclu...

biorxiv.org

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Johannes Pilic johannes-pilic.bsky.social · Apr 29, 2025
Origin and evolution of mitochondrial inner membrane composition journals.biologists.com/jcs/article/...
Origin and evolution of mitochondrial inner membrane composition

Summary: An examination of the morphological similarities between prokaryotic intracytoplasmic membranes and mitochondrial inner membranes, and whether cristae evolution has driven specialization of t...

journals.biologists.com

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Christian Frezza handle.invalid · Apr 29, 2025
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Christian Frezza handle.invalid · Apr 29, 2025
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Times Higher Education (THE) timeshighered.bsky.social · Apr 9, 2025
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Johannes Pilic johannes-pilic.bsky.social · Mar 24, 2025
Preventing Multimer Formation in Commonly Used Synthetic Biology Plasmids | ACS Synthetic Biology pubs.acs.org/doi/full/10....
Preventing Multimer Formation in Commonly Used Synthetic Biology Plasmids

Plasmids are an essential tool for basic research and biotechnology applications. To optimize plasmid-based circuits, it is crucial to control plasmid integrity, including the formation of plasmid mul...

pubs.acs.org

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Kai Johnsson kjohnsson.bsky.social · Feb 7, 2025
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Christian Frezza handle.invalid · Mar 21, 2025
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urialonlab urialonlab.bsky.social · Feb 24, 2025
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Johannes Pilic johannes-pilic.bsky.social · Feb 21, 2025
Interesting preprint about ATP gradients within cells: www.biorxiv.org/content/10.1...
Estimating physical conditions supporting gradients of ATP concentration in the eukaryotic cell

The ATP molecule serves as an energy currency in eukaryotes (and all life), providing the energy needed for many essential cellular processes. But the extent to which substantial spatial differences e...

biorxiv.org

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urialonlab urialonlab.bsky.social · Feb 4, 2025
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Joachim Goedhart joachimgoedhart.bsky.social · Jan 30, 2025
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dyechemist dyechemist.bsky.social · Jan 28, 2025
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Flo Camus handle.invalid · Jan 28, 2025
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Viktoria Cologna handle.invalid · Jan 20, 2025
Our global study on the state of trust in scientists is now out in Nature Human Behaviour! 🥳 With a team of 241 researchers, we surveyed 71,922 people in 68 countries, providing the largest dataset on trust in scientists post-pandemic 👇🧵https://www.nature.com/articles/s41562-024-02090-5

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PLOS Biology plosbiology.org · Jan 16, 2025
Pericentromeric #heterochromatin clusters into chromocenters. @skrutlnize.bsky.social &co use quantitative mass spec to characterize the chromocenter proteome in multiple tissues, identifying a link between satellite DNA-binding proteins & #transposon repression🧪 @plosbiology.org plos.io/4akuNAi

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Johannes Pilic johannes-pilic.bsky.social · Jan 9, 2025
FLIM imaging reveals IMM lipid heterogeneity in live cells. Find out more about this exciting tool: onlinelibrary.wiley.com/doi/10.1002/...

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Juan C. Landoni 🔬 jclandoni.bsky.social · Dec 23, 2024
Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

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Joachim Goedhart joachimgoedhart.bsky.social · Nov 25, 2024
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Joachim Goedhart joachimgoedhart.bsky.social · Jan 6, 2025
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Johannes Pilic johannes-pilic.bsky.social · Jan 3, 2025
Interesting article: rupress.org/jcb/article/...
Functionally conserved inner mitochondrial membrane proteins CCDC51 and Mdm33 demarcate a subset of fission events | Journal of Cell Biology | Rockefeller University Press

Edington et al. determine that Mdm33 and CCDC51 are functionally conserved mitochondrial inner membrane proteins that are required for normal mitochondrial

rupress.org

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Andy Moore aaandmoore.bsky.social · Dec 17, 2024
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lemackz lemackz.bsky.social · Dec 17, 2024
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Tina Perica handle.invalid · Dec 16, 2024
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Johannes Pilic johannes-pilic.bsky.social · Dec 9, 2024
Looks interesting: www.sciencedirect.com/science/arti...
Reactive oxygen species control protein degradation at the mitochondrial import gate

While reactive oxygen species (ROS) have long been known to drive aging and neurodegeneration, their persistent depletion below basal levels also disr…

sciencedirect.com

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av2atb av2atb.bsky.social · Dec 6, 2024
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Robert Arkowitz handle.invalid · Dec 4, 2024
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Christian Frezza handle.invalid · Dec 3, 2024
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Johannes Pilic johannes-pilic.bsky.social · Dec 2, 2024
Very interesting approach to visualize proteins. www.nature.com/articles/s41...
Designing artificial fluorescent proteins and biosensors by genetically encoding molecular rotor-based amino acids - Nature Chemistry

The toolbox of artificial fluorescent proteins can be expanded by engineering mimics of the molecular rotor-based fluorophore found in the green fluorescent protein (GFP) into diverse protein scaffold...

nature.com

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Dylan Burnette mag2art.bsky.social · Dec 2, 2024
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Juan C. Landoni 🔬 jclandoni.bsky.social · Dec 2, 2024
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axonsalex axonsalex.bsky.social · Nov 20, 2024
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chusteckisci chusteckisci.bsky.social · Nov 15, 2024
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willmair willmair.bsky.social · Nov 22, 2024
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Juanma Schvartzman schvartzman.bsky.social · Nov 22, 2024
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Johannes Pilic johannes-pilic.bsky.social · Nov 23, 2024
Finally moved to #Bluesky and happy to share our recent work! We found that hexokinase 1 rapidly forms rings around #mitochondria during energy stress to regulate mitochondrial fission: www.cell.com/molecular-ce... For a quick summary of our findings, check out the comment section.

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Johannes Pilic johannes-pilic.bsky.social · Nov 23, 2024

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alexpapac alexpapac.bsky.social · Nov 23, 2024
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Johannes Pilic johannes-pilic.bsky.social · Nov 23, 2024
Visualizing mitochondrial membrane proteins in live cells can be challenging due to the size of fluorescent protein tags (~240 residues). In our recent paper, we show how a small tetracysteine tag (6 residues) enables accurate visualization of VDAC1 in live cells. journals.plos.org/plosone/arti...
Visualizing VDAC1 in live cells using a tetracysteine tag

The voltage-dependent anion channel 1 (VDAC1) is a crucial gatekeeper in the outer mitochondrial membrane, controlling metabolic and energy homeostasis. The available methodological approaches fell sh...

journals.plos.org

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Johannes Pilic johannes-pilic.bsky.social · Nov 23, 2024
How do #mitochondria decide when to divide or fuse? I’ve always thought mtDNA played a key role in this process, so I was very surprised by this finding: The loss of mtDNA does not affect mitochondrial fission and fusion rates. www.molbiolcell.org/doi/10.1091/...
Significantly reduced, but balanced, rates of mitochondrial fission and fusion are sufficient to maintain the integrity of yeast mitochondrial DNA | Molecular Biology of the Cell

Mitochondria exist as dynamic tubular networks and the morphology of these networks impacts organelle function and cell health. Mitochondrial morphology is maintained in part by the opposing activitie...

molbiolcell.org

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aliciakowaltowski aliciakowaltowski.bsky.social · Nov 21, 2024
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