- Proud to be part of this incredible multidisciplinary team uncovering why some people are NOT infected by Salmonella. This new Wellcome Trust @wellcometrust.bsky.social funding will allow us to uncover why some people naturally resist infection and colonisation by Salmonella Typhimurium.
- NEWS | Professor @jayhinton.bsky.social and an international team have been awarded £4.56M Wellcome Discovery Award to investigate natural human resistance to Salmonella 🔗 bit.ly/4hujsRG @livuninews.bsky.social | #TeamLivUni
- We believe that this colonisation resistance is driven by the human gut microbiota -we will test our hypotheses experimentally & aim to define the mechanisms involved The exciting project builds on outstanding work of @mgibani.bsky.social & team who developed Salmonella CHANTS human challenge model
- Bringing this together required a truly multidisciplinary effort — combining expertise with human challenge models, Salmonella–microbiota interactions, Salmonella biology and advanced multi-omics approaches including metagenomics, metatranscriptomics, and metabolomics.
- We’re especially grateful to Wolf-Dietrich Hardt & @mgibani.bsky.social for suggesting the idea; to @lisamaierlab.bsky.social for bringing her remarkable TurboFerm high-throughput fermenter technology; to @blancaps.bsky.social for her expertise in Salmonella genomics and transcriptomics;
- to @edcoakes.bsky.social and the CGR team for mastering vast metagenomic and metatranscriptomic datasets; to @roygoodacre.bsky.social and his colleagues at the CMR for their next-level metabolomic insights; to @acdarby.bsky.social and to @livuni-livsrf.bsky.social
- Can't wait to see this project folding up. Congrats Jay.
