Jason Yeung
MD-PhD candidate @utmbhealth interested in viruses and data science | Former ballet dancer using publicly available dance data for advocacy
jason-yeung.netlify.app
datapointesguide.com
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- What is going on with ldlr proteins and arboviruses?? Some kind of vector/mammalian host coevolutionary constraint??
- More interesting work that furthers this thread between SARS-CoV-2 recombination, the RTC complex, polymerase backtracking, and antiviral drug mechanisms of action. The biochemistry behind viral recombination is still very much open. Some personal notes on these:
- As someone who previously knew little about Orientia tsutsugamushi, it was surprising to learn how many cases there are: "Within endemic regions, commonly known as the tsutsugamushi triangle, there are an estimated one million cases annually[...]". Currently working on something related
- The preprint is out! Congratulations to @ywangapril.bsky.social on this investigation into leading DENV drugs. Possible in large part due to the AViDD center grants…
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- A lot of discussion re: assay development and tissue-level sampling for persistence. To really get at how persistence is generated needs measurable longitudinal markers amenable to mathematical modeling akin to viral load for HIV. Modeling was transformational for treatment strategies there.
- This gene and PLSCR1 keep showing up in host factor CRISPR screens. Still ambiguous what they exactly do but definitely act early before interferon. Interestingly, DAZAP2 KO largely shows up as a hit when the screen has an earlier end point (shorter than 4-7 days)
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- 6 years ago, I started a data science project that landed me a board position at a non-profit featured in the NY Times. My first career was as a professional ballet dancer straight out of high school. I was good enough to stick around and keep jobs but not to advance quickly. ->
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- It's been a momentous few years for both Dengue and DENV antiviral development - particularly for the JNJ and NITD NS4B inhibitors. New preprint from my thesis lab sheds some light on the differences between the two companies' compounds (they don't work the same way): www.biorxiv.org/content/10.1...
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- Doing adventofcode.com to build up those Rust skills! 🎄🦀 Joined late but it's resolving my "I have no reason to use Rust" dilemma
- Reposted by Jason YeungLetter sent in to the Editor of the Guardian on brain microbiome nonsense.
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- What a paper. I somehow missed all of the UTMB seminars about this work. There sorely needs to be an updated review article on the molecular basis for coronavirus recombination because I keep getting lost in the weeds. Some thoughts:
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- 📢 This is my public plea 📢 for more scientific medium-form content. I discuss the "riff" as my favorite format for sharing and building relationships online. Blogging as an academic has more benefits than you may think: jason-yeung.netlify.app/posts/2024_9...
- Excellent piece on long COVID funding that also mentions the dissolution of the AViDD network. As someone who sat in on a few of the meetings at UTMB, there were very exciting collaborations occurring due to the grant. Hard not to see the recent ReVAMPP awards as a scaled down AViDD with new people.
- An R Shiny use case I found few examples of: I built a crowdsourcing app! Submission of new info, voting on data accuracy, and cookies to avoid having to create logins. Just Google Sheets and MongoDB. Now the hard part - getting people to contribute to it
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- As someone who uses R for bioinformatics/data science, I was seduced by the idea of learning Rust after noticing an uptick in high performance Rust tools on my feed. I briefly talk about my approach to learning the language and my frustrations: jason-yeung.netlify.app/posts/2024_6...
- Viral persistence is the most important theory for #LongCovid at the moment. What are challenges researchers face studying viral persistence? In this post, I discuss scientific barriers and criteria I use to evaluate models of #SARSCoV2 #viralpersistence: jason-yeung.netlify.app/posts/2023_1...
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