Jake Choby
Assistant Professor, University of North Carolina
Antibiotic heteroresistance in Enterobacterales
chobylab.org
- Reposted by Jake Choby[Not loaded yet]
- Reposted by Jake ChobyDelighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...
- Reposted by Jake ChobySuper excited to share our paper online 🚨today🚨 in Cell Host & Microbe! Xiaomei Ren @xiaomeiren.bsky.social and Mason Clark @rmasonclark.bsky.social co-led discovery of ecological factors for Acinetobacter baumannii carriage in the gut, a reservoir for pathogen spread. 🎉 tinyurl.com/443kfefk
- Amino acid competition shapes A. baumannii gut carriage Acinetobacter baumannii uses ornithine to compete w/ microbiota & persist in gut. Amino acid supplementation & differences in diet promote A. baumannii gut colonization in mice & humans @laurenpalmer.bsky.social www.cell.com/cell-host-mi...
- Excited to share the work with @dweisslab.bsky.social and great collaborators on how gene amplification generates dynamic heteroresistance to new beta-lactams, like cefiderocol. We hope drug developers will consider heteroresistance during antibiotic development rdcu.be/euijW
- It's a good time to mention that I’ve just started as an assistant professor at the University of North Carolina SOM, Micro & Immuno, where we will work to understand mechanisms that generate heteroresistance and phenotypic heterogeneity in Enterobacter and other multi-drug resistant Gram- pathogens
- Reposted by Jake Choby[Not loaded yet]
- Reposted by Jake Choby[Not loaded yet]
