Holmes Lab
The Holmes Lab works to understand the genetic and brain bases of individual differences in network organization across psychiatric illness.
📍Rutgers, Center for Advanced Human Brain Imaging Research
holmeslab.rutgers.edu
- Reposted by Holmes LabLooking for a post-bac RA position focused on the brain bases of affective and psychotic illness? @holmeslab-bhi.bsky.social is hiring! @cahbir.bsky.social @rutgersbhi.bsky.social @rutgersu.bsky.social @sobp-org.bsky.social @hitop-system.bsky.social @ohbmofficial.bsky.social
- The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Please rt and reach out if you’re interested 👀 Find out more holmeslab.rutgers.edu
- Holmes Lab + Parkes Lab had a great fall social a few weeks back!! Pottery painting (including an awesome brain-art mug by @ambrains.bsky.social 🧠). Thank you to our awesome mentors @avramholmes.bsky.social and @lindenmp.bsky.social for encouraging these great lab events! 💫
- Reposted by Holmes LabThe @cahbir.bsky.social and @rutgersbhi.bsky.social are hiring! Multiple open area and open rank faculty jobs, wonderful colleagues, amazing resources, and one of the largest communities of brain science research groups on the planet. Please apply and share widely. jobs.rutgers.edu/postings/209...
- Reposted by Holmes LabLatest @holmeslab-bhi.bsky.social preprint. Here, integrating genetic, post-mortem, and diffusion MRI data, Rowena Chin examines the heritability and cellular associates of late-life decline in white matter integrity. @cahbir.bsky.social @rutgersbhi.bsky.social www.biorxiv.org/content/10.1...
- Great write up of the @nature.com study on MRI economics by @bttyeo.bsky.social's research group! With @avramholmes.bsky.social @sidchop.bsky.social @carrisacocuzza.bsky.social
- When powering fMRI studies, sample size is king, but scan duration can also be a powerful tool, improving phenotypic prediction and cost-efficiency, a new analysis shows By @claudia-lopez.bsky.social #neuroskyence www.thetransmitter.org/fmri/longer-...
- Reposted by Holmes Lab🚨Thrilled to share our latest work just published in @nature.com where we looked into the optimal fMRI scan time for brain-wide association studies (BWAS) 🧠⏱️! Full thread below👇:
- 1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...
- Reposted by Holmes LabThis new Yeo Lab tool should immediately and permanently replace sample-size-only power calculations for functional MRI. www.nature.com/articles/s41...
- 8/ In contrast to standard power calculations, our results suggest that jointly optimizing sample size and scan time can boost prediction accuracy while cutting costs. For more complex study design, you can check out our calculator: thomasyeolab.github.io/OptimalScanT...
- Reposted by Holmes LabEveryone should try out the Trandiagnostic Connectome Project (TCP) dataset! Openly available on @openneuro.bsky.social
- V useful paper by @bttyeo.bsky.social @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social in @nature.com. Scan longer if you want to predict behav using fMRI and save $. Great use of the TCP data: (pmc.ncbi.nlm.nih.gov/articles/PMC...).
- Reposted by Holmes LabNature research paper: Longer scans boost prediction and cut costs in brain-wide association studies go.nature.com/3IME4aA
- Holmes Lab is representing at #OHBM2025! 🧵 Loic @loiclabache.bsky.social presented in the Language: Anatomy, Networks and Pathology section with his paper on "The molecular and cellular underpinnings of human brain lateralization" 🧠
- Ashlea @ashleasegal.bsky.social is doing amazing work as the Chair of the OHBM Student and Postdoc Special Interest Group (SP-SIG), which has also been putting out amazing programming all year long 😍
- And Amber @ambrains.bsky.social is killing it as the Art Exhibition Manager for the OHBM Brain Art SIG! 🎨 Major kudos to all of you, and have fun at the last day!! #OHBM
- Reposted by Holmes LabCheck out our latest open data release. n=240, most with a dsm-5 dx with extensive phenotying (~100 scales/subscale), rest and task functional imaging. See @carrisacocuzza.bsky.social's thread below for deets and links 👇🏾👇🏾👇🏾
- 🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉 www.nature.com/articles/s41... 🧵1👇
- Reposted by Holmes LabVery cool preprint examining how brain networks and cognition co-evolve during development By @bttyeo.bsky.social @lucinauddin.bsky.social @avramholmes.bsky.social @elvisha.bsky.social & colleagues 🧪🧠 www.biorxiv.org/content/10.1...
- Reposted by Holmes LabCheck out my newest preprint to see the TCP dataset in action! 🤘🧠 Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease: www.biorxiv.org/content/10.1...
- 🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉 www.nature.com/articles/s41... 🧵1👇
- If you missed it, our open source 240-person transdiagnostic dataset is now published. Read the data release 👇👇 + find it on: OpenNeuro: openneuro.org/datasets/ds0... NDA: nda.nih.gov/study.html?i...
- Check out our latest open data release. n=240, most with a dsm-5 dx with extensive phenotying (~100 scales/subscale), rest and task functional imaging. See @carrisacocuzza.bsky.social's thread below for deets and links 👇🏾👇🏾👇🏾
- Reposted by Holmes Lab🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉 www.nature.com/articles/s41... 🧵1👇
- Reposted by Holmes LabOur latest @holmeslab-bhi.bsky.social data release is now "live!" Available on NDA and @openneuro.bsky.social and spearheaded by @carrisacocuzza.bsky.social, @sidchop.bsky.social, and Connor Lawhead.
- 🚨 Dataset & Manuscript alert! 🚨 The Transdiagnostic Connectome Project (TCP) manuscript is now available @natureportfolio.nature.com Scientific Data! 🎉 www.nature.com/articles/s41... 🧵1👇
- Reposted by Holmes LabBrain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease biorxiv.org/content/10.1101/202…
- Reposted by Holmes LabNew @holmeslab-bhi.bsky.social paper led by @carrisacocuzza.bsky.social. Brain dynamics across task and rest can be used to predict the presence of psychiatric illness (case/control status), diagnostic labels, and multi-dimensional symptom fingerprints. @rutgersbhi.bsky.social @rutgersu.bsky.social
- 🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘 www.biorxiv.org/content/10.1... Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇
- Check out Carrisa's new paper! An amazing investigation into brain network dynamics across psychiatric symptoms🔥🔥 + using our new open dataset the Transdiagnostic Connectome Project (TCP) 🔛 openneuro.org/datasets/ds0...
- 🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘 www.biorxiv.org/content/10.1... Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇
- Great lab outing to Duke Farms yesterday! Happy spring from the Holmes + Parkes labs 😄 🌸 With @lindenmp.bsky.social @avramholmes.bsky.social @carrisacocuzza.bsky.social @ahmadbeyh.bsky.social @loiclabache.bsky.social (+ Amber Howell & Rachel Cooper)
- Reposted by Holmes LabWe're searching for a lead Research MRI technologists at @cahbir.bsky.social! Please share and pass along to any/all interested folks.
- CAHBIR at Rutgers University is looking for a Lead Research MRI Technologist. CAHBIR is a research-only facility that focuses on neuroimaging, and other MR imaging projects. If you are interested, see the information flier linked, and apply online! go.rutgers.edu/mri-tech
- Last month Linden Parkes and his team put out an amazing new work! They build on their network control theory model & improved whole-brain structure-function coupling Check this 🧵 for a summary 🔥 www.biorxiv.org/content/10.1...
- Excited to share the first major piece of work and preprint from my lab! Led by Jason Kim! 🥳🎉🤘 www.biorxiv.org/content/10.1...
- Reposted by Holmes LabWhile the world burns, we cook up a new preprint! doi.org/10.1101/2025... Biophysical modeling is a key tool to derive mechanistic insights into the brain. These models are governed by biologically meaningful parameters (unlike artificial neural networks), but the dirty secret ... 1/N
- Newest #preprint from Holmes lab postdoc @loiclabache.bsky.social 🔥
- 🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization 🔗 doi.org/10.1101/2025... 🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇 #neuroskyence
- Reposted by Holmes LabThe molecular and cellular basis of human brain lateralization. Latest paper from @holmeslab-bhi.bsky.social led by @loiclabache.bsky.social. @rutgersbhi.bsky.social, @cahbir.bsky.social
- 🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization 🔗 doi.org/10.1101/2025... 🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇 #neuroskyence
- Check out the new article by our very own PI, Avram Holmes!
- Until recently, in-vivo brain imaging has largely been absent from… integrative efforts, limiting the opportunities to contribute our discoveries, theories or vision toward a comprehensive view of brain function, writes @avramholmes.bsky.social. #neuroskyence www.thetransmitter.org/future-of-fm...
- Reposted by Holmes Lab"To make a meaningful contribution to #neuroscience, #fMRI must break out of its silo." My latest attempt to convince you of the importance of multi-scale approaches for the study of the human brain.
- Until recently, in-vivo brain imaging has largely been absent from… integrative efforts, limiting the opportunities to contribute our discoveries, theories or vision toward a comprehensive view of brain function, writes @avramholmes.bsky.social. #neuroskyence www.thetransmitter.org/future-of-fm...
- Reposted by Holmes Lab🧠 Featured Insights! Dr. @avramholmes.bsky.social, Associate Prof of Psychiatry at RWJMS and Core Member of BHI & CAHBIR, shares insights on #fMRI and the need for integration across #neuroscience disciplines in @thetransmitter.bsky.social www.thetransmitter.org/future-of-fm... #neuroimaging
- PsyPost covered @lydiaquq.bsky.social's new paper linking internalizing/externalizing symptoms to distinct features! Check it out ⬇️ 🖇️https://www.psypost.org/scientists-identify-distinct-brain-patterns-linked-to-mental-health-symptoms #SciComm #Neuroscience
- Check out the latest Holmes Lab pre-print from @sidchop.bsky.social 🔥
- 🧩New study: "Network Constraints on 𝘪𝘯 𝘷𝘪𝘷𝘰 Synaptic Alterations in Schizophrenia" medrxiv.org/content/10.1... We map a prominent brain-wide pattern of synaptic defects in people with Schizophrenia using PET, then model the molecular, cellular & connectomic features shaping this pattern 🧵1/3👇
- Reposted by Holmes LabGreat new work from @sidchop.bsky.social here at @orygen.org.au. @lenapl.bsky.social @matthewbroome.bsky.social @paoladzn.bsky.social
- 🧩New study: "Network Constraints on 𝘪𝘯 𝘷𝘪𝘷𝘰 Synaptic Alterations in Schizophrenia" medrxiv.org/content/10.1... We map a prominent brain-wide pattern of synaptic defects in people with Schizophrenia using PET, then model the molecular, cellular & connectomic features shaping this pattern 🧵1/3👇
- We have stopped accepting applications for this role. Thank you to everyone who has applied!
- The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Please rt and reach out if you're interested👀 Find out more holmeslab.rutgers.xn--edu-6p63b
- New in-depth feature about @OrchardWinnie's paper on health.com! Read it here: www.health.com/parents-youn... 🗣️Featuring comments from Dr @OrchardWinnie, Dr Avram Holmes, Dr Michelle Diblasi (Psychiatrist @TuftsMedicalCtr) and Dr Andrew Thaliath (@NortonNeuro)
- Reposted by Holmes LabRaising children protects the brain against aging, according to an analysis of UK Biobank [link to accounts below] data. As benefits were observed in men and women, they are likely caused by the mental workout of caregiving, rather than pregnancy. In PNAS: www.pnas.org/doi/abs/10.1...
- Some Holmes Lab members at the Stand Up For Science 2025 in Philly! A great day with talks from superb scientists, council members and activists #standupforscience2025 #StandUpForScience
- The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Please rt and reach out if you're interested👀 Find out more holmeslab.rutgers.xn--edu-6p63b
- We are thrilled that Holmes lab recent paper by Xihan Zhang et al. has been featured on the cover of The Transmitter!@thetransmitter.bsky.social! Check out the paper here: tinyurl.com/cellnetworks And the article 🖇️ 🧬 www.thetransmitter.org/neuroanatomy...
- The Holmes Lab is #hiring a full-time research assistant/predoc! Our work focuses on functional brain networks-- how they change, how they are impacted in psychiatric illness, and much more! Unfortunately, we cannot sponsor visas for this position. Please rt and reach out if you're interested👀
- Find out more about us and read our recent publications on our website! holmeslab.rutgers.edu 🧠 #MRI #fMRI #neuroscience #hiring #predoc #postbacc #researchassistant #labmanager
- Reposted by Holmes LabThe cerebral cortex is intricately organized, both at the level of cell types and macroscale functional networks. Those organizational layers are intertwined, as each network consists of a distinct blend of cell types, a new study finds. By Holly Barker www.thetransmitter.org/neuroanatomy...
- Reposted by Holmes Lab🧠 Parenthood may have unexpected brain benefits! A new study led by Dr. Avram Holmes @avramholmes.bsky.social suggests that raising children could help protect against some effects of aging. 📖 Read more: www.pnas.org/doi/10.1073/... www.rutgers.edu/news/how-par...
- Reposted by Holmes LabCongrats to Winnie Orchard & @sidchop.bsky.social on their new #ParentalBrain paper, now out in PNAS! They find evidence for the neuroprotective effect of parenthood for women AND men! 👩🍼👨🍼🧠 It's lovely work, and I'm proud to have played a tiny role in it. Read it here 👇 #neuroskyence #neuroimaging
- New paper‼️ Interested in the protective impacts of parenthood on brain dynamics? 👨👩👦👦🧠 Read Edwina Orchard & @sidchop.bsky.social's new paper, out now in PNAS @pnas.org ! With collaborators L. Ooi, P. Chen, L. An @bttyeo.bsky.social, and more! 🔗https://tinyurl.com/parentalbrain
- Some great coverage of @OrchardWinnie's new PNAS paper! A 🧵 (1/3) www.rutgers.edu/news/how-par... How does parenthood impact your brain? Check out Winnie's paper here: tinyurl.com/parentalbrain
- Science Daily 🧵 (2/3) www.sciencedaily.com/releases/202...
- New paper‼️ Interested in the protective impacts of parenthood on brain dynamics? 👨👩👦👦🧠 Read Edwina Orchard & @sidchop.bsky.social's new paper, out now in PNAS @pnas.org ! With collaborators L. Ooi, P. Chen, L. An @bttyeo.bsky.social, and more! 🔗https://tinyurl.com/parentalbrain
- Reposted by Holmes LabNew @holmeslab-bhi.bsky.social paper by Lydia Qu. Here, we map shared and unique brain features for individual variation in internalizing and externalizing across development. w/@bttyeo.bsky.social, @elvisha.bsky.social, @carrisacocuzza.bsky.social, and many others. www.nature.com/articles/s44...
- Reposted by Holmes LabA Perspective on considering the interconnected nature of social identities in neuroimaging research 🧪🧠 @elvisha.bsky.social www.nature.com/articles/s41...
- Reposted by Holmes LabThrilled to kick 2025 off w/ this amazing tour de force led by @elvisha.bsky.social. Grateful to have been involved in this work highlighting the importance of considering #intersectionality in #neuroimaging @natureneuro.bsky.social
- Thrilled to share our latest work on the importance of considering social identities in brain imaging research, now out in @natureneuro.bsky.social. rdcu.be/d4XWM
- Reposted by Holmes Lab“Without diverse representation in human neuroscience research, we risk developing a skewed understanding of the brain and behavior.” Check out the coverage of our latest work: feinstein.northwell.edu/news/the-lat... Paper: www.nature.com/articles/s41...
