hjerling-leffler
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- Reposted by hjerling-leffler🥁🎇✨ ... first up is KIRA HÖFFLER @kirahoeffler.bsky.social from the #UniversityofBergen in Norway and #McLeanHospital in Boston ! So tell us, Kira, what do you do in #functionalgenomics and @pgc_fg ?🤔 Any #funfacts #genetics 🐝❓ 🧵3/3
- Reposted by hjerling-leffler🌟Today @fg-pgc.bsky.social and @pgcgenetics.bsky.social are in Bengaluru, India, where we love to highlight Dr KALYANI BINDU's work and the dynamic #functionalgenomics scene 🧬🧠 She shows that many of the same biological mechanisms play a role in different #mentalhealth disorders ! One drug for all?
- Reposted by hjerling-leffler🌟for our last portrait, @fg-pgc.bsky.social is back in Germany @unibonn.bsky.social, where Dr EVA BEINS @evabeins.bsky.social studies #genetics and #microglia in #depression & #bipolardisorder. Think #brain #immune cells and #mentalhealth 🧠🧬👨🎓
- Reposted by hjerling-lefflerOur last, but by NO means least, group is the ✨Single Cell Transcriptomics✨group! Our two awesome chairs lead this group, with @hjerling-leffler.bsky.social focusing on brain🧠, and @maryellenlynall.bsky.social on immune🦠 🧵1/2
- Reposted by hjerling-lefflerFirst paper from the lab is now online @natneuro.nature.com ! We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵 rdcu.be/eSQi1
- Thrilled to share our new publication on the regulatory code of injury responsive enhancers in the CNS! www.nature.com/articles/s41... @ellorens.bsky.social @ki.se @natneuro.nature.com
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- Reposted by hjerling-lefflerWell when it rains it pours. My son Will @fishell_will , just published a paper on biorxiv, much closer to my heart with my lab member Suraj Honnuraiah on spiking neural networks and understanding why they struggle as LLMs. www.biorxiv.org/content/10.1...
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- Reposted by hjerling-lefflerHey bsky-ers! New preprint from the lab on #psilocybin & social behaviour in #female mice in contexts relevant to eating disorders (food restriction, exercise & combo of) by PhD student Sheida 💙🦋
- Psilocybin exerts differential effects on social behaviour and inflammation in mice in contexts of activity-based anorexia (ABA) biorxiv.org/content/10.1101/202…
- Final speaker in the first session of (news.ki.se/calendar/dev...) with Michael Ziller (Muenster) talking about functional genomics of scizophrenia
- Next up in our great line up at Developing Brains (news.ki.se/calendar/dev...) is Beatriz Rico (King’s College)
- Kicking off the 12th edition of the Developing Brain Conference (news.ki.se/calendar/dev...) with Cecile Charrier (ENS).
- Reposted by hjerling-lefflerA rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible! www.sciencedirect.com/science/arti...
- Having a great time at the HiiLIFE Science Days at @Helsinki.fi Gracious hosts, beautiful venue, fantastic science and plenty of real coffee.
- Reposted by hjerling-lefflerIncredibly proud of @kxhuang.bsky.social for persisting with such a challenging dataset from her PhD! We found some intriguing genetic targets in a corticostriatal circuit that may be involved in the development of #anorexia nervosa 🤔 onlinelibrary.wiley.com/doi/10.1002/...
- Reposted by hjerling-lefflerHow do neutrophils contribute to mental health? Delighted to share research led by @staceykigar.bsky.social: meningeal neutrophils shape how the brain responds to stress. Out today @natcomms.nature.com. More in the thread⬇️ @psychiatry-ucam.bsky.social @medcambridge.bsky.social @camneuro.bsky.social
- ‼️ New manuscript alert ‼️ I’m thrilled to share this work examining chronic stress-related “depression” and immune cells at the blood brain barrier: www.nature.com/articles/s41...
- Reposted by hjerling-lefflerUnderstanding why antidepressants don't always work 🧠🛡️ New research by @maryellenlynall.bsky.social reveals the key role played by the immune system in symptoms of depression. 📖https://bit.ly/469cXyI
- Reposted by hjerling-lefflerNew updated on how pyramidal neurons impact interneuron subtypes. Turns out spontaneous activity, Wnt signaling in PV Interneurons and integrin-signaling in SST neurons are the culprits! Also see how optimal transport tracks identity.https://www.biorxiv.org/content/10.1101/2024.07.20.604399v2
- Reposted by hjerling-lefflerA major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
- Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. 🔗 All positions: ki.se/en/about-ki/...
- Reposted by hjerling-lefflerWow Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions ki.se/en/about-ki/...
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- I definitely never regretted the decision to leave New York for Stockholm and Karolinska - now you can join us: big call for assistant professors across medical disciplines coming up. news.ki.se/ki-to-recrui...
- Reposted by hjerling-leffler#neuroskyence folks: as my postdoc grant is running out soon, I am looking for new opportunities in systems neuroscience! Keywords: patch clamp ephys, opto, mouse behavior, (in vivo) voltage imaging. Would love to return to the Basal Ganglia. Sharing appreciated, and happy #FluorescenceFriday !
- Reposted by hjerling-lefflerOur study on the impact of altered serotonin (5-HT) signalling on the developing sensory cortex is now live at Nature Comms. We use longitudinal in vivo imaging of 5-HT and neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction of sensory areas.
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- Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...
- Reposted by hjerling-lefflerHappy to share that I will kickstart my research group at @ki.se this autumn!🎉🎉 Are you interested in glial biology, using high-end tools for gene and cell programming to study metabolic and epigenetic interactions? Stay tuned! Will be 🔭 for RA, PhD-students & postdocs! Let the journey begin! 🧬🧫🔬
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- A recent preprint from the lab. Turns out biology trumps technical measures for benchmarking of transcriptomics.
- Reposted by hjerling-lefflerThrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
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- Reposted by hjerling-lefflerCheck out this cool work from my superstar student Elie developing a new dimensionality reduction algorithm that compares two conditions! It works on many types of data
- Does your research involve comparing experimental conditions? Then our latest publication is for you: We developed generalized contrastive PCA (gcPCA), a tool for comparing high-dimensional datasets. 🧠📊 doi.org/10.1371/journal.pcbi.1012747 This tool was born out of necessity, here is the story. 🧵 1/
- Reposted by hjerling-lefflerDoes your research involve comparing experimental conditions? Then our latest publication is for you: We developed generalized contrastive PCA (gcPCA), a tool for comparing high-dimensional datasets. 🧠📊 doi.org/10.1371/journal.pcbi.1012747 This tool was born out of necessity, here is the story. 🧵 1/
- Reposted by hjerling-lefflerWe are looking for a PhD student! If you are interested in Drosophilids, systematics, bioinformatics, fiddling with museum specimens of old/weird flies, and chemosensation, then maybe this is for you! Please rebutterfly(?)! Apply below. lu.varbi.com/en/what:job/...
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- Alert! Postdoc positions available - at least two. Interested in coming to Karolinska and work on adolescent development/schizophrenia? Have a background in neuroscience, functional genomics, computational analysis or spatial transcriptomics? Large data sets available for analysis. Get in touch!
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- Reposted by hjerling-lefflerHot off the press! 🧬🔬 We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ: doi.org/10.1126/scie...
- Reposted by hjerling-lefflerAre you an established (”distinguished”) researcher outside Europe? Thinking of moving here for some reason? Grant opportunity just dropped: www.vr.se/english/appl...
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- Reposted by hjerling-lefflerOne of Norway's largest fuel companies just announced that they will no longer refuel US Navy vessels after Trump’s treatment of Zelenskyy. “It made us sick... We encourage all Norwegians and Europeans to follow our example.”
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- Reposted by hjerling-leffler'Did you even say thank you?'
- I want to thank all the people moving through my lab and all my collaborators for making this possible! Time do get dr*nk!
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- Reposted by hjerling-lefflerA great line-up of speakers for the "Blueprints of life: cell fate choices and lineages" conference @ki.se organized by @anderssonlab.bsky.social To register 👇 news.ki.se/calendar/blu...
- Reposted by hjerling-leffler⚠️Useful!⚠️ Protocol for assessing myelination by human iPSC-derived oligodendrocytes in Shiverer mouse ex vivo brain slice cultures by Themistoklis Tsarouchas, @erinmgibson.bsky.social @lidazoupi.bsky.social @annawilliamslab.bsky.social #neurosky www.sciencedirect.com/science/arti...
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- Reposted by hjerling-lefflerJust giving this a boost for those who may not have seen it yet... we have a PI position (molecular and cellular basis of cognition) at The Hospital for Sick Children (Toronto). The position comes with an appointment at Assist/Assoc Prof level at U of T. Share widely! can-acn.org/scientist-se...
- Reposted by hjerling-lefflerPostdoc recruitment for an ERC-funded project! Are you eager to resolve embryonic cell fates with next generation single cell linege tracing? We use in utero barcoding & omics to map development, providing a basis for high throughput perturbations.. Pls re-post! Apply: ki.varbi.com/en/what:job/...
- Reposted by hjerling-lefflerExcited to see Moscot (moscot-tools.org) published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at www.nature.com/articles/s41...
- Excited to share our latest paper from a collab w Patrick Sullivan and others where results from two different data-driven approaches (GWAS/human-snRNAseq and fMRI) converge on the amygdala and hippocampus as key regions for schizophrenia: nature.com/articles/s41...
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- Reposted by hjerling-lefflerHey, so it turns out that paper on black plastic was a bit blown out of proportion by a simple math error. nationalpost.com/news/canada/...
