Hesso Farhan
Professor at the Medical University of Innsbruck, Austria. Interested in Endoplasmic Reticulum, Mechanobiology, Proteostasis, Organelles, Cell migration, Pseudoenzymes
- Reposted by Hesso FarhanJoe Shen’s and Zaza Gelashvili’s work on the role of the ER in nuclear membrane mechanotransduction finally came out in a journal!
- Reposted by Hesso FarhanERC success rates are tanking and the move is... even bigger grants for fewer people? smh
- · #AcademicSky · The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.
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- Reposted by Hesso FarhanPeiyao Fan, Yang Chen et al. @pku1898.bsky.social show that tubular ER extends into retraction fibers and #migrasomes through #microtubule-dependent ER extension and ER-plasma membrane contact sites in migrating cells. rupress.org/jcb/article/... #ER_literature #Migration #Organelles
- Reposted by Hesso FarhanWhat do ER exit sites really look like? Using large-scale volume FIB-SEM and a custom 3D-Unet pipeline (ASEM), Nahir et al @kirchhausenlab.bsky.social reveal that ERES are vesicular, abundant & diverse, resolving long-standing morphological discrepancies rupress.org/jcb/article/... #ER_literature
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- Reposted by Hesso FarhanJoel Mokyr, Philippe Aghion and Pewter Howitt share economics prize for work that underlines the importance of investing in research and development. go.nature.com/4hj9NNV
- Reposted by Hesso FarhanBei #Grundlagenforschung kürzen? Keine gute Idee! so die Philosophin @asmeincke.bsky.social in ihrem Gastkommentar in @diepressecom.bsky.social. Denn Österreich brauche eine starke und vielfältige Wissenschaft. @fwf-at.bsky.social @oeaw.bsky.social Bessere Ideen 👉 www.diepresse.com/20152064/bei...
- Reposted by Hesso FarhanCheck out this new Roadmap, a fantastic team effort by a consortium of ER researchers. Glad we could provide the space for this synthesis, which came out of discussions at a fruitful meeting, see below:
- ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions. www.nature.com/articles/s41...
- It was a great pleasure to work on this paper. What started as a small meeting in January this year resulted in this beautiful piece of work.
- ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions. www.nature.com/articles/s41...
- The microbial metabolite preQ1 modifies tRNA, reduces cell proliferation, and decreases protein translation. This is mediated by IRE1-dependent cleavage of preQ1-modified tRNAs. rdcu.be/eHw46
- Beautiful work which supports a role for the ER in mechanobiology.
- Reposted by Hesso FarhanNature research paper: Quantitative imaging of lipid transport in mammalian cells go.nature.com/4mmSygd
- New paper by the Reggiori and Ungermann Labs showing using a yeast model that contact sites between the phagophore and ERES are important for phagophore elongation. rdcu.be/ezUeZ
- Great preprint showing that COPII vesicles do exist in vicinity of ERES. Very interesting.
- Go check out the latest preprint from Giulia Zanetti's lab. @dr-downes.bsky.social used cryo-tomography to directly visualize COPI and COPII coated vesicles in situ at unprecedented resolution in human cells. Amazingly beautiful, rigorous, insightful work. www.biorxiv.org/content/10.1...
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- Reposted by Hesso FarhanVery happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
- Our review on the role of ER proteostasis in bone disease is out today in Trends in Molecular Medicine www.cell.com/trends/molec...
- Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work rdcu.be/evyfX
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- Reposted by Hesso Farhan🚨 Where does #lipid peroxidation kick off in #ferroptosis? 🔥Excited to reveal #ER- #mitochondria #contactsites as the ignition point of the lipid peroxidation cascade! Huge kudos to our Maria Livia Sassano @mariamls.bsky.social & our amazing collaborators who made this breakthrough possible!
- Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass: Developmental Cell www.cell.com/developmenta...
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- Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage: Cell www.cell.com/cell/fulltex...
- Genetically encoded reporters of actin filament organization in living cells and tissues: Cell www.cell.com/cell/fulltex...
- Excited to present our unpublished data tomorrow on how Mechanosesing at the Endoplasmic Reticulum regulates Proteostasis. #Organelles #Mechanobiology
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- Reposted by Hesso FarhanA great tribute to David Stevens, a terrific cell biologist and missed by so many of his friends and colleagues. As they say 'one of the good guys'. journals.biologists.com/jcs/article/...
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- Reposted by Hesso FarhanImportant to celebrate trainee victories: excited to have Holly Merta's @hollymerta.bsky.social paper out! We use TurboID sub-organelle proteomics to map the ER network. We find calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility. www.sciencedirect.com/science/arti...
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- Reposted by Hesso FarhanUnbelievable. Richard Youle, winner of the Breakthrough Prize for Life Sciences, just got fired from the NIH. If you want to know what madness looks like, here it is, my friend.
- NEW: The doctor behind breakthrough Parkinson’s research was among the scientists purged from the National Institutes of Health, the US’s leading medical research agency. www.wired.com/story/doctor...
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- New paper by my colleagues Taras Valovka and Lukas Huber. Congrats on the nice work and the beautiful cover image JCI Insight - Altered chaperone–nonmuscle myosin II interactions drive pathogenicity of the UNC45A c.710T>C variant in osteo-oto-hepato-enteric syndrome insight.jci.org/articles/vie...
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- Reposted by Hesso FarhanIn Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
- Reposted by Hesso Farhanwww.science.org/doi/10.1126/... Tour de force by Barna Lab
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- Reposted by Hesso FarhanWe've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....
- Reposted by Hesso FarhanOur paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?! doi.org/10.1016/j.cu...
- Very interesting preprint by the Burd group www.biorxiv.org/content/10.1...
- The first sermon!
- The first supper before our ERES meeting
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- How true: Misinformation exploits outrage to spread online www.science.org/doi/10.1126/...
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- This is an interesting an helpful read: Elements of successful NIH grant applications www.pnas.org/doi/10.1073/...
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- Reposted by Hesso FarhanHow do organelles fit together inside a crowded cell? Answering this question requires a way to image many organelles in a whole cell at high resolution with high throughput. Our new preprint shows how to do this in yeast using soft x-ray tomography www.biorxiv.org/content/10.1...
