- Very excited about this project: we believe that 3D anatomical atlases have a huge potential for developmental biology. As a starting point, we made the first ever Drosophila wing disc atlas!
- BrainGlobe branches out! New blog outlining our collaborative work with @giuliapaci.bsky.social from @lmcb-ucl.bsky.social to build anatomical atlases for developmental mechanobiology. brainglobe.info/blog/drosoph...
- Please tell us more-what data does it include?
- Sure! The population-averaged template was generated from 16 individual 3D images of female larval wing discs (~110–120 h AEL) expressing a membrane marker (Ubi-EGFP-CAAX). As a proof of principle, we manually annotated the main anatomical regions (pouch, hinge, notum, and peripodial layer).
- We plan to further expand the annotations using region-specific genetic markers (e.g. A/P compartments, intervein regions). The current resolution is 2 µm, already quite high compared with most brain atlases (10–100 µm), and can be further increased to capture finer anatomical details.
- Any 3D wing disc images from a comparable stage can be aligned to our atlas and automatically segmented into the annotated sub-regions. The atlas is built within the @brainglobe.info ecosystem, so we can leverage its open-source Python tools for registration, visualization and analysis.Oct 11, 2025 04:38
