Very excited about this project: we believe that 3D anatomical atlases have a huge potential for developmental biology. As a starting point, we made the first ever Drosophila wing disc atlas!
BrainGlobe branches out!
New blog outlining our collaborative work with
@giuliapaci.bsky.social from
@lmcb-ucl.bsky.social to build anatomical atlases for developmental mechanobiology.
brainglobe.info/blog/drosoph...
Sure! The population-averaged template was generated from 16 individual 3D images of female larval wing discs (~110–120 h AEL) expressing a membrane marker (Ubi-EGFP-CAAX). As a proof of principle, we manually annotated the main anatomical regions (pouch, hinge, notum, and peripodial layer).
Does this mean you have segmented cells and have single cell resolution?
No we don't have single cells segmented here: since the template is meant to be a representative "average" wing disc, it would be challenging / impossible to align different samples at single cell resolution. It's meant to resolve relatively large anatomical regions (e.g. pouch, interveins...)
