Hani Goodarzi
Core Investigator @ Arc Institute | Associate Professor @ UCSF | {Computational, Systems, Cancer, RNA} biologist | Co-founder @exaibio @vevo_ai
- Reposted by Hani GoodarziArc Core Investigator @genophoria.bsky.social will speak on a free, online panel with @tkaraletsos.bsky.social, @emmalundberg.bsky.social, and @ronalfa.bsky.social on Wed., Oct. 29, as part of GENbio's “The State of AI in Drug Discovery in 2025.” Register at: webinars.liebertpub.com/e/the-state-...
- Reposted by Hani GoodarziHear how Arc, Ultima Genomics, and @10xgenomics.bsky.social are partnering to generate perturbation data at the scale needed to train virtual cell models on The Bio Report podcast with guests @genophoria.bsky.social, Gilad Almogy, and Serge Saxonov: thebioreport.podbean.com/e/transformi...
- Reposted by Hani Goodarzi#CELLFIE for CAR T screening—a new mRNA-based platform for screening primary cells. CAR + gRNA library are delivered by lentivirus, CRISPR modifiers as electroporated mRNA. That’s more flexible and effective than existing T cell screening methods. (1/7)
- Reposted by Hani GoodarziNew work from stellar scientists Jeremy Williams and Roman Camarda. Many contributors including the amazing Zena Werb and Atul Butte Work explores how breast cancer cells interact directly with adipocytes via gap junctions, leading to lipid release. @ctbatucsf.bsky.social @ucsfcancer.bsky.social
- Reposted by Hani GoodarziRNA N-glycosylation enables immune evasion and homeostatic efferocytosis by chemically caging acp3U. Excited to report this work lead by Vinnie @vinnieviruses.bsky.social and in collaboration with @vijayrathinam.bsky.social in @nature.com www.nature.com/articles/s41...
- Reposted by Hani GoodarziMy colleagues at Nature Biomedical Engineering @natbiomedeng.nature.com are hiring an associate or senior editor. Ideal applicant will have expertise in immunology, immunotherapy, or immuno-oncology. Please feel to ask me questions! springernature.wd3.myworkdayjobs.com/SpringerNatu...
- Go @exai.bio! Looking forward to working with Mike as our incoming CEO and our amazing board members.
- Reposted by Hani GoodarziAre you currently in the ERE related field & want to find new collaborative opportunities? Join our Chairs @chiappinellilab.bsky.social, @shenhui1986.bsky.social, Ting & Tao at #EREHD25 this Nov! 🎙️Talk Submission extended to 03 Sept 💰Final few $500 grants remaining Don't Miss out! bit.ly/4eRq9Mp
- Reposted by Hani GoodarziOur ENS is vital to gut-brain health. When it breaks down, so does health. Treatments? Almost none. Access to functional human enteric neurons at scale powers disease modeling and therapeutic discovery. Grateful to everyone who made this possible. www.nature.com/articles/s41...
- Oh no! I am devastated!
- Reposted by Hani GoodarziCheck out this amazing work from @genophoria.bsky.social’s lab, revealing a novel post-transcriptional tumour suppressive programme in breast cancer 👇👇
- Been going back and forth on whether it makes sense to post science in the midst of all that is happening. But here it goes with a couple of days of delay: www.biorxiv.org/content/10.1...
- Been going back and forth on whether it makes sense to post science in the midst of all that is happening. But here it goes with a couple of days of delay: www.biorxiv.org/content/10.1...
- Sharing our lab’s latest preprint, led by @heatherkarner.bsky.social and @tabeamittmann.bsky.social. Our study describes a post-transcriptional network that governs mRNA dynamics contributing to breast cancer heterogeneity.
- Gene expression has long been synonymous with transcription. While we and others have functionally implicated post-transcriptional regulatory programs in cancer, the relative contribution of post-transcriptional mechanisms in reshaping the cancer transcriptome is unknown.
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View full threadWe would especially like to thank all of our colleagues who collaborated with us on this, including @balynzaro.bsky.social and Albertas Navickas, for their contributions to this work. And our funders, including @arcinstitute.org.
- Reposted by Hani Goodarzi🧬💊 @science.org Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase | Science www.science.org/doi/10.1126/... @sternberglab.bsky.social @isaacwitte.bsky.social eitzingersimon.bsky.social + al. #CRISPR #Medicine #Science #Evolution #Genome #evoCAST
- 1/10 Today in @science.org in collaboration with the Liu group we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-Ub...
- Really excited to see this published! From observations we made in our lab… to a blood test that works in real life scenarios… all thanks to the many scientists, ML researchers and engineers at @exai.bio who have worked on bringing this to the clinic. Kudos @babak-a.bsky.social and the team!
- 💥New Publication Alert in Clinical Cancer Research💥 We are thrilled to announce our latest publication on our novel RNA and generative AI liquid biopsy platform for early colorectal cancer detection. #EarlyDetection #LiquidBiopsy #RNA Read the full publication here: aacrjournals.org/clincancerre...
- Reposted by Hani GoodarziExcited for this summer’s NYC Chromatin Club! Grad students & postdocs: submit your abstracts for a chance to present a poster or talk. Come connect w/ fellow epigenetic New Yorkers! #NYCChromatinClub @dshechter.bsky.social @vivrisca.bsky.social @epicypher.bsky.social @kjarmache.bsky.social
- Reposted by Hani GoodarziDelighted to see this out! Fun fact: I actually started my lab @ UCSF w/ goal of understanding tRNA txn regulation, which aligned perfectly w/ @genophoria.bsky.social & Sohail! 6+ years of amazing collaboration & stellar work by Siyu, Albertas, & co & we're making real progress w/ more to come!
- Check out our latest preprint, led by Dr. Siyu Chen, that brings together an amazing team of scientists from several labs ( @vram142.bsky.social, Tavazoie, and Navickas) to tackle a fundamental problem in biology: how do cells regulate expression of their tRNAs? www.biorxiv.org/content/10.1...
- Check out our latest preprint, led by Dr. Siyu Chen, that brings together an amazing team of scientists from several labs ( @vram142.bsky.social, Tavazoie, and Navickas) to tackle a fundamental problem in biology: how do cells regulate expression of their tRNAs? www.biorxiv.org/content/10.1...
- About a decade ago, a few groups (including ours) reported strategies for globally profiling tRNA abundance in cells. It became clear that tRNA levels can be cell-type specific, and that changes in tRNA abundance can impact translational efficiency in a codon-dependent manner.
- That leaves open a big question: how are”tRNAomes” regulated? Unlike Pol II genes, where TF-based regulation is the now-accepted paradigm, we know far less about how Pol III promoters are regulated in a sequence / locus-specific manner. This gap is where our study begins.
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View full threadMore broadly, we think ZZEF1 is the first of many such regulatory interactions to emerge. We describe a blueprint for revealing the underlying language of tRNA expression—with implications for chromatin biology, translational control, and human disease.
- Reposted by Hani GoodarziPleased to have our reviewed preprint out now @elife.bsky.social Outstanding work by Drs. Rachel Nakagawa, Dan Van de Mark, and Andrew Beardsley. Shout out to @genophoria.bsky.social, Mary-Kate Hayward and many others Press Release Here elifesciences.org/for-the-pres... @ucsfcancer.bsky.social
- Reposted by Hani GoodarziCheck out our latest work on one of the first multi-modal cell-free RNA foundation models for blood surveillance and liquid biopsy applications, led by @genophoria.bsky.social, @babak-a.bsky.social, @mehrankr.bsky.social and Aiden Sababi
- Joining forces with the legendary @babak-a.bsky.social, @fhormozd.bsky.social, and @mkarimzadeh.bsky.social to bring you Exai-1; a multi-modal cell-free RNA foundation model for blood surveillance and liquid biopsy applications. Kudos to the broader @exai.bio team! www.biorxiv.org/content/10.1...
- Reposted by Hani GoodarziSuper excited to share that our paper on a multi-modal cell-free RNA foundation model is out! A fantastic collaboration with @genophoria.bsky.social, @fhormozd.bsky.social and the @exai.bio team!
- Joining forces with the legendary @babak-a.bsky.social, @fhormozd.bsky.social, and @mkarimzadeh.bsky.social to bring you Exai-1; a multi-modal cell-free RNA foundation model for blood surveillance and liquid biopsy applications. Kudos to the broader @exai.bio team! www.biorxiv.org/content/10.1...
- Reposted by Hani Goodarzi1/ It has been a privilege to have the opportunity of contributing to Exai-1. Shout out to my co-first author, Aiden Sabadbi, and my amazing colleagues @exai.bio, particularly @fhormozd.bsky.social, @babak-a.bsky.social, and @genophoria.bsky.social who led the effort.
- Joining forces with the legendary @babak-a.bsky.social, @fhormozd.bsky.social, and @mkarimzadeh.bsky.social to bring you Exai-1; a multi-modal cell-free RNA foundation model for blood surveillance and liquid biopsy applications. Kudos to the broader @exai.bio team! www.biorxiv.org/content/10.1...
