Frank van Leth
Epidemiologist. Intersection methodology, infectious diseases and social science. Vrije Universiteit Amsterdam. Dept. Healh Sciences, Head section International Health. Vice-director Amsterdam Public Health research institute. #TB #HIV #AMR #syndemics
- Seen in downtown Athens. Had a good laugh. Somebody needs some PR advise.
- An account to follow. Already 20 years in collaborative #TB #tuberculosis researh across Europe.
- Reposted by Frank van Leth🆕⚡🧠HARVEST TRIAL:More Rifampin,Same Fate: High-Dose Rifampin Fails to Shift the Needle in TB Meningitis,NEJM,2025 Despite better theoretical CNS penetration,high-dose oral rifampin did not improve survival in adult TB meningitis & potential harm cannot be excluded #idsky www.nejm.org/doi/full/10....
- A strange argument on energy consumption of data centers: "you need to have your data close by. We need to invest in more data centers" I do not need to hug my data. I just need storage in Europe. Efficient sharing instead of unlimited expansion. Energy and water consumption *is* an issue
- Our yearly conference is about to start. Amsterdam Public Health research institute. #APH. Imporrant topic. Let's roll!!
- Opening by our director. Sustainability refers to planet and people. Think helth inequalities and sustainable wirk force
- Wouter Henekamp and Niek Sperna Weiland perform together: making big choices for sustainability
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View full thread#APH societal impact magazine. I hope the QR code works from a picture. Enjoy!
- Reposted by Frank van LethWe did a thing. 😬
- The link between the gut #microbiome and autism is not backed by science, researchers say. Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA @wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
- This is a great opportunity. Come and work with us in this wonderful team.
- We are seeking a PhD student💡. 4-yrs 💶 for 🇲🇿 in locally co-designed #airborne infection control, #AMR surveillance in 🇿🇦 🇳🇬 Based in Maputo (FundacaoAurum) #TBSky #EpiSky @fvlscience.bsky.social Lusophone health/ lab w/ roots in 🇲🇿 #PublicHealth #EDCTP3 @itmantwerp.bsky.social Q: emitchell@itg.be
- Reposted by Frank van LethTB deaths up 5% in 6 months since USAID funds pulled from Napula, Mozambique: #USAID #TBsky #TBFighters #tuberculosis observador.pt/2025/09/24/t...
- Reposted by Frank van Leth#IDsky Unfortunately, despite a promising premise, Clofast did not pan out for shorter duration w/clofazamine rifapentine regimen (3 months) vs RIPE (6 mo). Shorter regimen had higher relapse rate, worsening radiographic response despite earlier cx conversion www.thelancet.com/journals/lan...
- Reposted by Frank van LethToday TAG launched some of our 2025 Pipeline Reports. You’ll find TB Treatment, along with all four HIV reports. Download them now! www.treatmentactiongroup.org/resources/pi...
- Reposted by Frank van LethA year after its breakout public health moment, 'miracle drug' lenacapavir has been approved by the FDA and recommended by the WHO. The drug is a long-lasting shot that provides almost 100% protection against HIV infection. buff.ly/E5zOvGl #ShareGoodNewsToo
- Reposted by Frank van LethThe @who.int has prequalified the first African-made first-line #HIV treatment. Its procurement by @globalfund.bsky.social marks progress in building resilient, self-sufficient health systems in Africa —still home to 65% of the global HIV burden. 🟠 f.mtr.cool/bdqvnetetr #GlobalHealth
- With the #jpiamr program closing, there is a final conference on its achievements. Nice gathering of funders, scientists of all walks, and policy makers. Lessons learned when moving to EU partnership OneHealth. Looking forward to new era.
- Great post. As always. Thanks
- New blog post! In which I explain the issue with mediation analysis and sketch out one way to deal with the underlying causal inference problem -- in just a bit over 1,000 words! If you have never found the time to read up on this, now is your chance. www.the100.ci/2025/03/20/r...
- Crowds are different. The anger is the same. Tembi 2 years after the train crash. #τεμπι.
- The Dutch gvt joins the move to shortsightedness. "Development aid only for projects with direct returns for the Netherlands". Exit sexual health, women partcipation, and climate. #development #aid #RSH. A sad day for many
- Reposted by Frank van LethThe WHO research agenda for #AMR in human health has identified 40 research priorities to be addressed by 2030, focusing on bacterial and fungal pathogens critical for AMR. Target is to encourage evidence generation for effective AMR policy translation www.sciencedirect.com/science/arti...
- The WHO's proposed research aims to identify and prioritize key topics to mitigate #AMR in human health, guiding policy-makers, researchers, funders, and other stakeholders in generating evidence to inform AMR policies and interventions. iris.who.int/handle/10665...
- Congrsts. Great and important work
- Proud to see the endTB trial, work of a huge team, led by @partnersinhealth.bsky.social, @msf.org, IRD & supported by @unitaid.bsky.social, published in @nejm.org today. Safe, effective, shortened treatments for drug-resistant TB can be available to all. #TBSky #ForeignAid tinyurl.com/NEJM-endTB
- Reposted by Frank van LethWe share a lot of our ideas, code, datasets (that we spend years sanitizing) early. Often way before we release preprints. We do this so that others can use, build on, improve & even "beat" our approaches. But I want to say a few things about some simple expectations 1/
- Reposted by Frank van LethThe Institute of Tropical Medicine in Antwerp launched the Armand Van Deun Scholarship Initiative in honour of his legacy. Armand was founding father of our short course Clinical Decision-Making for Drug-Resistant Tuberculosis (DR-TB) @ITM. Read more: www.itg.be/en/health-st...
- Reposted by Frank van LethOur work on immortal time bias "Illustrating the structures of bias from immortal time using directed acyclic graphs" led by Emma Guoyi Yang @yanggy_hku is out at International Journal of Epidemiology: doi.org/10.1093/ije/.... Brief thread:
- Reposted by Frank van Leth⚠️ Bit of an alarm bell to MDR-TB regimen BPaL/M - resistance to constituent antibiotics developing and transmission of such strains already occurring #TBSky #IDSky @nejm.org www.nejm.org/doi/10.1056/...
- Reposted by Frank van LethFake or flawed studies are polluting systematic reviews in medicine and other fields - but how do you spot them? For Nature, I report on efforts to create a short checklist of red flags, and on the automated integrity tools emerging to help. www.nature.com/articles/d41...
- Reposted by Frank van Lethindianexpress.com/article/citi... Access to drugs continues to be a major concern for TB control. All the science in the world can't help if we can't get the drugs. #TBSky #endTB HT Ankita Upadhyay on twitter.
- Rather happy with this one. We used a Lot Quality Assurance Sampling (LQAS) approach in surveillance of #AMR in #UTI in Indonesia. Working on this rapid surveillance approach for quite a while. doi.org/10.1093/aje/...
- Science friends 🧪🌎🦑, @altmetric.com tracks Bluesky posts now! Quote or reply to this post with a link to the paper you’re best known for or most proud of, and a brief plain-language summary of what you found and why it matters! Let’s fill Bluesky with SCIENCE!
- Reposted by Frank van LethA hub-and-spoke approach to implementing #AntimicrobialStewardship programmes (ASPs) in Zambian hospitals improved the core elements of #AMS practice and modestly reduced antibiotic use over 1 year, offering insights for strengthening ASPs in Africa: buff.ly/4ghXvDP #JACAMRNews
- Reposted by Frank van LethWe call for a more flexible One Health approach to prioritize localized AMR research in critical settings like hospitals and care facilities. This would address urgent human health needs while supporting broader integrative goals. www.bmj.com/content/386/...
- Reposted by Frank van LethTuberculosis: a biosocial problem that requires biosocial solutions www.thelancet.com/journals/lan...
- Reposted by Frank van LethWHO-prequalified test is the same one that Cepheid claims to be selling “at cost”. But, in nearly 15 months since making that claim, Cepheid & its parent, Danaher, refuse to provide any evidence for it. The product is priced at 60% above a 2019 estimate of its cost + reasonable profit. 🧵
- Reposted by Frank van LethI'm advertising a PhD studentship (open to international students) on understanding how temperature may alter the ecology and evolution of AMR. Might suits someone with a microbiology/wet lab background who wants to expand into ecoevo. Or vice versa! But interest more important than experience.
- Reposted by Frank van LethReproducing my viral thread from Twitter on why we should stop using the term "sub-Saharan Africa" Academics routinely use this term. For many years, I also used it without really thinking much about it or questioning its use. But it’s problematic and should be avoided. Here are the reasons:
- Reposted by Frank van LethLet’s start with a test: Think you can beat #misinformation? Try this #MisinformationSusceptibilityTest It only takes 2-5 minutes! ➡️ yourmist.streamlit.app #InfodemicManager #KCGH
- It’s warm and cosy inside here at the KCGH Symposium 🍂 Navigating Truths: Demystifying Mis- and #Disinformation in (Global) Health #PublicHealth #EpiSky #AcademicSky www.kcgh.nl/activiteiten...
- Reposted by Frank van LethWe're thrilled to announce that we’ve begun preparing for the stable (1.0) releases of all packages in our ecosystem. Releases are expected early next year. If you’ve been using any of these packages, we would greatly value your feedback on the API: easystats.github.io/easystats/ #rstats #easystats
