Florian Tesson
PhD student at @mdmlab.bsky.social
between INSERM and Pasteur Institute
- Reposted by Florian Tesson🦠🧫 Envie d'en savoir plus sur la Microbiologie et de découvrir l'Institut Pasteur ? Rejoignez nous pour conférence scientifique grand public, accompagnée d’une performance artistique le 27 janvier à 18h! Inscrivez-vous :) research.pasteur.fr/fr/event/con...
- Reposted by Florian TessonAdvancing Fast-Track Genome Engineering in Bacillus subtilis Phages ACS Synthetic Biology pubs.acs.org/doi/10.1021/...
- Reposted by Florian TessonBacterial genomes encode a rich repertoire of antiphage systems, but we still know surprisingly little about when these systems are actually expressed. In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts. www.biorxiv.org/content/10.6...
- Reposted by Florian Tesson🧬🛡️How are new immune mechanisms created? We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org. 👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors! doi.org/10.1073/pnas...
- Reposted by Florian TessonWe built GenoPHI: a machine learning workflow that predicts phage-host interactions at strain level. This could help rapidly select phages to treat drug-resistant bacterial infections or for microbiome engineering without exhaustive lab testing. www.biorxiv.org/content/10.1...
- Reposted by Florian TessonJOB OFFER #PhageSky We have a postdoc position opening in my group to investigate phage-MGE interactions ! We're based in the very nice city of Lyon, France @mmsb-lyon.bsky.social Contact me for more info ! >> Apply on the CNRS webpage emploi.cnrs.fr/Offres/CDD/U...
- Reposted by Florian TessonExcited to finally share this work! We noticed a pair of genes - a nuclease and a protease - shuffles between antiviral systems. We show how proteolysis activates the nuclease, triggering defense in known and unknown immune contexts. tinyurl.com/2uwwy4ty
- Reposted by Florian TessonExcited to share the work that’s been on my mind for the past 2 years, now on bioRxiv! Led with Matt Walker, and my first project in the Sternberg Lab . Check it out ⬇️ tinyurl.com/mshwjd77
- Reposted by Florian TessonFirst preprint from the Nemudryi Lab! 🍾 In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages. www.biorxiv.org/content/10.1...
- Reposted by Florian Tesson🧬 From bacteria to humans: a new study led by @institutcurie.bsky.social, @institutpasteur.bsky.social & @inserm.fr reveals SIRal, a novel human immune protein with ancestral roots. A new path for immunotherapy? 🔗 Read: www.pasteur.fr/en/press-are...
- Reposted by Florian Tesson🦠🧍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...
- Reposted by Florian Tesson📢Preprint out! Excited to share my final work from the @soreklab.bsky.social! We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery. Found 3 new families targeting immune signaling!
- Reposted by Florian TessonLe Palais de la Découverte est menacé! Il a contribué à éveiller ma passion pour la science quand j'étais petit. Nous devons tout faire pour protéger ce lieu unique qui a toute sa place au cœur de Paris. Signez la pétition ici: chng.it/BnR9gZvhL2
- Reposted by Florian TessonThe Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes biorxiv.org/content/10.1101/202…
- Reposted by Florian TessonWhite smoke, we have a new pope and also 16 new anti-phages systems in sedentary integrons (SCIs) ! In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones. www.science.org/doi/10.1126/...
- Reposted by Florian TessonOut in Nature today: A new immune signaling molecule, His-ADPR, is produced by defensive TIR domain proteins in bacteria to protect from phage Joint work with the Tamulaitienė and Kranzusch labs www.nature.com/articles/s41... Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!
- Reposted by Florian TessonIt was an honor for my lab and myself to host the meeting on the Immune Systems of Bacteria. Such a high from all the incredible science and sharing with scientists from the whole world the greatness of Paris in the spring. Vive la science, et vive Paris!
- Reposted by Florian TessonStructural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery biorxiv.org/content/10.1101/202…
- Reposted by Florian TessonCBASS, CRISPR, and mCpol- oh my! What a satisfying collaboration with @aaronwhiteley.bsky.social 's lab- we uncovered a new cyclic dinucleotide signaling pathway, but it doesn't work how you'd expect! Check out the thread from @aesully98.bsky.social for an overview of the most important findings!
- Excited to share that my work from the @aaronwhiteley.bsky.social lab is now on bioRxiv! With @benmorehouse.bsky.social, we discovered that the Panoptes defense system—named after the all-seeing watchman of Hera—uses decoy nucleotides to detect phage anti-defense proteins.
- Reposted by Florian TessonNew online! Genetics, ecology and evolution of phage satellites
- Reposted by Florian TessonHello BlueSky! Inaugural post here from the Sternberg Lab. We're excited to share our latest work, in which we teamed up with the @WiedenheftLab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: www.biorxiv.org/content/10.1...
- Reposted by Florian TessonNew version of DefenseFinder available defensefinder.mdmlab.fr (& cli) Now encompassing 263 systems (+111 this year..!). Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models
- Reposted by Florian TessonHappy to share our latest piece of work on the PARIS bacterial immune system. We performed a detailed characterization of the AriB Toprim nuclease, the effector of PARIS immunity. www.biorxiv.org/content/10.1...
- Reposted by Florian TessonHuge thanks to my sister for helping put these together.
- Reposted by Florian TessonI'm thrilled to announce our latest work is now published in Cell! Viruses encode numerous proteins that inhibit host defenses, but identifying immune-modulatory proteins among millions of viral sequences has been nearly impossible - until now! www.cell.com/cell/fulltex...
- Reposted by Florian TessonPhage defence system abundances vary across environments and increase with viral density www.biorxiv.org/content/10.1... #jcampubs
- Reposted by Florian TessonThe Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋 The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...
- Reposted by Florian Tesson👋 Hi antiphage defense community, we are soon releasing an update of DefenseFinder. We are doing our best to include all the great discoveries from the community, but with so much going on we might miss things. Please answer wt preprints/papers with new systems or mail/git them to us. 🙏
- Reposted by Florian Tesson
Excited to share our work using machine learning to predict anti-phage defense systems! 1/n- DefensePredictor: A Machine Learning Model to Discover Novel Prokaryotic Immune Systems biorxiv.org/content/10.1101/202…
- Reposted by Florian TessonWhat is the diversity of antiphage systems out there ? We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families. Leb by E. Mordret. www.biorxiv.org/content/10.1... Interactive UMAP to have fun mdmparis.github.io/antiphage-la...
- Reposted by Florian TessonOut in NAR, AntiDefenseFinder & our "systematic" analysis of inhibitors of antiphage systems wt Bondy-Denomy lab led by @ftesson.bsky.social and E. Huiting. Not so "systematic" as very few known, fun stuff on MGE, antidefense islands and cool phages exaptations! academic.oup.com/nar/advance-...
- Reposted by Florian TessonHappy to see our paper out @ Nat Comm We discovered a bacterial NLR-like pattern recognition receptor that can sense 3 different viral proteins as a signature for infection. This explains its broad defense against different phage families Congrats Nathalie Béchon! www.nature.com/articles/s41...
- Reposted by Florian TessonAnother day, another cool recent preprint on bacterial immunity. #Phagesky This one is on an super cool regulation of Restriction-Modification systems. Post-translational modifications that are temperature dependent AND inherited over 60 generations. www.biorxiv.org/content/10.1...
- Reposted by Florian TessonOut in Nature Microbiology, we predicted phage-bacteria interactions in E. coli species using only genomic information. Adsorption, not defense systems, is the main driver at this scale (relevant for a phage therapy context), leading to tailored cocktails! www.nature.com/articles/s41... 🧵👇
- Reposted by Florian Tesson💻🧫 New preprint: How accurately can we predict diverse phage bacteria-interactions from their genomes only ? We created a matrix of >38k phage-bacteria interactions to find out (=> AUROC 86%) & used our predictions to recommend tailored phage cocktails. www.biorxiv.org/content/10.1...
