Francesco Iorio
Research group leader @humantechnopole, cancer researcher, algorithm designer, dad, cook, failed singer, resting runner 😉
- Reposted by Francesco Iorio𝗧𝘄𝗼 𝗶𝗻𝗱𝗲𝗽𝗲𝗻𝗱𝗲𝗻𝘁 analyses, 𝗼𝗻𝗲 𝗰𝗼𝗻𝘃𝗲𝗿𝗴𝗶𝗻𝗴 𝘀𝘁𝗼𝗿𝘆: here is 𝗈𝗎𝗋 𝗇𝖾𝗐 𝗌𝗍𝗎𝖽𝗒, 𝗋𝖾𝗅𝖾𝖺𝗌𝖾𝖽 𝖺𝗅𝗈𝗇𝗀𝗌𝗂𝖽𝖾 𝖺𝗇 𝗂𝗇𝖽𝖾𝗉𝖾𝗇𝖽𝖾𝗇𝗍 𝗐𝗈𝗋𝗄 𝖿𝗋𝗈𝗆 𝗍𝗁𝖾 𝗖𝗶𝗿𝗶𝗲𝗹𝗹𝗼 𝗴𝗿𝗼𝘂𝗽 (𝗦𝗲𝘀𝗶𝗮 𝗲𝘁 𝗮𝗹.), 𝗐𝗁𝖾𝗋𝖾 𝖢𝖱𝖨𝖲𝖯𝖱 𝖽𝖾𝗉𝖾𝗇𝖽𝖾𝗇𝖼𝗒 𝗆𝖺𝗉𝗌 𝖺𝗋𝖾 𝗎𝗌𝖾𝖽 𝗍𝗈 𝗍𝖺𝖼𝗄𝗅𝖾 𝗍𝗁𝖾 𝗌𝖺𝗆𝖾 𝖼𝗁𝖺𝗅𝗅𝖾𝗇𝗀𝖾: 𝗆𝖺𝗄𝗂𝗇𝗀 𝗌𝖾𝗇𝗌𝖾 𝗈𝖿 𝖼𝖺𝗇𝖼𝖾𝗋 𝘷𝘢𝘳𝘪𝘢𝘯𝘵𝘴 𝘰𝘧 𝘶𝘯𝘬𝘯𝘰𝘸𝘯 𝘴𝘪𝘨𝘯𝘪𝘧𝘪𝘤𝘢𝘯𝘤𝘦 using DepMap data. Links 👇
- Reposted by Francesco IorioI'm super excited to announce that I will join the Human Technopole @humantechnopole.bsky.social in Milan in April 2026 as a Research Group Leader.
- Reposted by Francesco IorioFestive vibes in Iorio Lab today: we spiced up the weekly lab meeting with a Secret Santa. Great company, fun gifts and a brief break from pipettes and plots!
- Reposted by Francesco Iorio💫 Thank you to all participants and speakers who joined us at the 2nd @eurocancerdepmap.bsky.social Symposium! Together, we’re advancing #cancer functional genomics across Europe. youtu.be/Qt_ozbzM5js
- Reposted by Francesco IorioLast but not least, we are thrilled to have representatives from academia, industry, foundations and publishers to share with us their take during the roundtable discussion on Bridging Sectors for Translational Impact!
- Reposted by Francesco IorioAnd we finish this session with @epetsalaki.bsky.social showing the potential of using CRISPR data to study context specific signalling and drug responses
- Reposted by Francesco IorioThe last session starts with Lodewyk Wessels from @nkinl.bsky.social sharing the work on perturbation response models!
- Reposted by Francesco Iorio@colmr.bsky.social takes the stage to share the work of his group that aims to understand and predict synthetic lethality between paralogs in cancer
- Reposted by Francesco Iorio@emanuelvgo.bsky.social insisting the metaphors used in @eurocancerdepmap.bsky.social presentations have strong Portuguese representation 😄
- Reposted by Francesco IorioNext we have @emanuelvgo.bsky.social , presenting the work on Minimal Libraries and use of AI-Synthetic Augmentation of CRISPR-Cas9 Screens for Drug Target Discovery
- Reposted by Francesco IorioWe are back, starting the afternoon session with a joint talk by Debora Sesia/ @ciriellolab.bsky.social and @aurorasavino.bsky.social / @ioriolab.bsky.social showing their work on the functional assessment of Variants of Unknown Significance through cancer dependency map data analysis
- Reposted by Francesco IorioTo wrap up the second session, Roland Rad from the Institute of Molecular Oncology and Functional Genomics is sharing their work on mapping genetic interactions in cancer evolution and therapy @eurocancerdepmap.bsky.social
- Reposted by Francesco IorioWe continue with the talk from @icrlordlab.bsky.social focusing on the complexity of synthetic lethality in cancer and how we can move forward in exploiting it @eurocancerdepmap.bsky.social
- Reposted by Francesco IorioFirst session of the @eurocancerdepmap.bsky.social symposium and so much fantastic work presented already! #CancerResearch #TranslationalScience #plasticity
- Reposted by Francesco IorioThe Synthetic Lethality and Innovations in CRISPR Screening session begins with @manuelkaulich.bsky.social telling us about exciting CRISPR libraries they have developed and how nuclear mRNA processing can mask the CRISPRko phenotypes @eurocancerdepmap.bsky.social
- Reposted by Francesco IorioNow @alejandrapcelab.bsky.social is taking us through the multidimensional map of early adaptation to treatment and how targeting cell plasticity can prevent childhood cancer relapse @eurocancerdepmap.bsky.social
- Reposted by Francesco IorioWe start with Carmen Herranz-Ors from @sangerinstitute.bsky.social giving us an overview of the impressive work done to generate Tumour Organoid Biobank and develop a 3D Dependency Map @eurocancerdepmap.bsky.social
- Reposted by Francesco IorioThe 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social
- Reposted by Francesco IorioDelighted to host Traver Hart (MD Anderson Cancer Center), who delivered an engaging seminar on synthetic lethality at #HumanTechnopole. He showed how bridging #CRISPR and predictive modeling can advance design and interpretation of genetic interaction screens and inform new therapeutic strategies.
- Last chance to register. Hurry Up!
- 🧬 Excited to announce the 2nd Euro Cancer DepMap Symposium bringing together leading minds in functional genomics, cancer vulnerabilities, AI, CRISPR and anti-cancer target discovery.📍Join us in Milan for cutting-edge science, open discussion & collaboration. #EuroDepMap #CancerResearch #CRISPR
- Reposted by Francesco IorioThe Iorio Lab is at the 37th AICC International Meeting in Florence this week. With our Francesco Iorio presenting as an invited speaker, Nevenka Radic with a flash talk and Vanessa Spagnolo with a poster. Excited to share our latest results and connect with colleagues in the field.
- Reposted by Francesco IorioKudos to our Flavio Passante for winning with his team the REMEDi4ALL Hackathon in Barcellona! Researchers from 10 countries tackled real-world challenges in drug repurposing for rare neurodevelopmental disorders, spanning the whole pipeline from early target discovery to market access.
- Congratulations Raffaele!
- Reposted by Francesco IorioOur very own Raffaele Iannuzzi successfully defended his PhD Thesis last week. Raf has worked on benchmarking CRISPRdata analytical tool and predictive models leveraging bulk & single cell RNA-seq data. We will definitely miss him. We wish him all the best as new adventures await! Congrats Raf! 🎉
- Reposted by Francesco Iorio!!! Less than 2 weeks left to register !!! Join us in Milan for the 2nd European Cancer Dependency Map Symposium, taking place on 20 November 2025 at Human Technopole Cancer functional genomics; CRISPR-based screening; AIdriven targetDiscovery and drug development humantechnopole.it/en/trainings...
- Reposted by Francesco IorioCLOSING: Postdoc in @francescoiorio.bsky.social's lab at @humantechnopole.bsky.social Apply through LinkedIn by 5 October: www.linkedin.com/jobs/view/43... #scienceJobs #AcademicSky #postdocJobs
- Reposted by Francesco IorioJoin us for this exciting meeting!
- 📢 The 2nd European Cancer Dependency Map Symposium is coming! 🗓️ 20 Nov 2025 📍 Human Technopole, Milan Join us for a one-day dive into: 🔹 Cancer genomics 🔹 CRISPR screening 🔹 AI-driven target discovery With the patronage of AIRC 🔗 humantechnopole.it/en/trainings...
- 📢 The 2nd European Cancer Dependency Map Symposium is coming! 🗓️ 20 Nov 2025 📍 Human Technopole, Milan Join us for a one-day dive into: 🔹 Cancer genomics 🔹 CRISPR screening 🔹 AI-driven target discovery With the patronage of AIRC 🔗 humantechnopole.it/en/trainings...
- Reposted by Francesco IorioFrancesco will be speaking at the High-Content CRISPR Screening conference, taking place March 18–19, 2026 in Vienna 🇦🇹 alongside leading experts in CRISPR screening, functional genomics, and drug discovery www.linkedin.com/posts/myllia...
- 10 September 2025
- Join Us! @ioriolab.bsky.social
- 🚨 We’re hiring! 🚨 looking for a computational postdoc to lead an exciting project at the intersection of AI, CRISPR, multi-omics, and cancer genomics. Join us to design the next generation of genetic interaction screens and uncover new synthetic lethalities www.linkedin.com/jobs/view/42...
- Reposted by Francesco IorioToday we bid farewell to our postDoc @aurorasavino.bsky.social, who is moving to an independent position at the University of Torino. Her talent dedication and collaborative spirit have left a lasting mark on our team and projects🎉 Wishing you all the best for this exciting next chapter, Aurora! 🥳🍾
- Excited to share that I’ve joined the Scientific Advisory Board of #DrugReKindle, a startup harnessing AI and computational biology to advance drug repurposing across human diseases. Grateful to the team for the opportunity. Looking forward to the journey ahead. www.linkedin.com/posts/drugre...
- Just back from the GRC on Synthetic Lethality in Oncology: great science, deep discussion, great venue and flawless organisation. Thanks to @mgarnett.bsky.social, Benjamin Schwartz & @vazquezf.bsky.social for leading a fantastic meeting at the frontier of cancer research #SyntheticLethality #GRC
- Reposted by Francesco IorioEnjoying the Gordon Conference on Synthetic Lethality in Oncology with @francescoiorio.bsky.social and @maxbillmann.bsky.social 😊 #bioinformatics #gordonConference #syntheticLethality
- happy and honoured to have had a chance to deliver a lecture @bocconi.bsky.social University on AIapplications in life sciences and to share exciting projects we are developing at @humantechnopole.bsky.social- A great opportunity to engage with a community that values innovation and forwardThinking
- great work from @davidjadams.bsky.social out now in @natgenet.nature.com (with a computational contribution from the @ioriolab.bsky.social @humantechnopole.bsky.social led by A.Vinceti)
- New work out in @natgenet.nature.com from @davidjadams.bsky.social Lab @sangerinstitute.bsky.social (with a contribution from us led by A.Vinceti): CDS2 is a cancer dependency in uveal melanomas with low CDS1 expression: a synthetic lethal axis with broad potential 🔗 www.nature.com/articles/s41...
- Proud to announce that the 2nd European Cancer DepMap Symposium has the patronage of AIRC: the Italian Association for Cancer Research. Honoured by their support as we bring together leading scientists on cancer-dependencies functional-genomics CRISPR 🔗 humantechnopole.it/en/trainings... #EuroDepMap
- Reposted by Francesco Ioriowe are at #EACR2025 with two posters - the second one is presented by Ludovica Proietti and Gianluca vozza and focuses on our ERC funded DEPshock project @humantechnopole.bsky.social
- Reposted by Francesco Ioriowe are at #EACR2025 with two posters, one presented by our Ottavio Croci on our collaborative work around a CRISPR based prioritisation of lncRNA vulnerabilities in multiple myeloma @humantechnopole.bsky.social
- Cingratulations @diegodibi.bsky.social !! Well deserved 💪
- I got an ERC Advanced Grant :))))) www.eurekalert.org/news-release...
- Following the success of the first European Cancer Dependency Map Symposium in 2023, we are excited to announce the 2nd edition, to be held at Human Technopole on the 20th November 2025. Registration and Poster submission now open! humantechnopole.it/en/trainings... youtu.be/x2erCuovGvc #EuroDepMap
- 🧬 Excited to announce the 2nd Euro Cancer DepMap Symposium bringing together leading minds in functional genomics, cancer vulnerabilities, AI, CRISPR and anti-cancer target discovery.📍Join us in Milan for cutting-edge science, open discussion & collaboration. #EuroDepMap #CancerResearch #CRISPR
- 🔬 Join us in Milan for the 2nd European Cancer Dependency Map Symposium #ECDM25! A key event for scientists in functional genomics & target discovery. Talks, panels, AI & poster sessions await. Register now 👉 humantechnopole.it/en/trainings...
- Reposted by Francesco Ioriowww.sciencedirect.com/science/arti... Just found out that our work on computational drug repositioning (mantra.tigem.it) among the 20 most cited articles worldwide in Scopus that are part of the collection. @francescoiorio.bsky.social
- Reposted by Francesco Iorio🤩 The February issue of @naturemethods.bsky.social features on its cover the research of our Giuseppe Testa Group on mosaic organoids to study the brains of multiple patients simultaneously. Read more about the research 👉 humantechnopole.it/en/news/mosa...
- Our February issue is live! 🎉 nature.com/nmeth/volume... On the cover, a human brain emerges from multiple stem cell lineages, representing a method to link genetic variation to neurodevelopmental trajectories. Paper here: nature.com/articles/s41... Image by Philipp Dexheimer.
- Reposted by Francesco IorioThe submission deadline has been extended to *8 May 2025*! "Genome Biology is calling for submissions to our Collection on key genetic determinants and functional consequences of genome editing interventions in the context of cancer." #CRISPR www.biomedcentral.com/collections/...
- Reposted by Francesco IorioHello, Bluesky! ☀️ We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late. Follow us for updates on ERC funding, research policy, and our grantees' discoveries.
- Reposted by Francesco Iorio(1/3) Excited to share our latest work using @depmap.org to uncover a new synthetic lethality in two distinct patient populations! We found that SKI complex inactivation through two independent genomic alterations creates a dependency on PELO #CancerResearch #SyntheticLethality #Genomics #DepMap
- Great and inspiring talk today at @humantechnopole.bsky.social delivered by Giorgio Galli from Novartis
- 🌟Today at @humantechnopole.bsky.social, Giorgio Galli from Novartis shared fascinating insights on "Genomic Approaches to Characterize Targets' Biology and Structure-Function Relationships".
- Reposted by Francesco IorioProbably a good time to remind my American friends that my institute here in Milan is recruiting broadly for everything from the postdoc to group leader level, and we have visa and immigration support 🇪🇺.
- Reposted by Francesco IorioAs the new Editor-in-Chief I encourage you to submit your work to Oncogenesis (IF 5,9) www.nature.com/oncsis/ High impact, peer-reviewed open access journal publishing articles exploring mechanistic insight and molecular basis of cancer and related phenomena.
- Reposted by Francesco IorioTrump’s anti-trans Executive Order is bad BUT it technically defines everyone as female. It states: “'Female' means a person belonging, at conception, to the sex that produces the large reproductive cell." Since all fetuses "at conception" are female, Trump just defined EVERYONE as female.
- Following Zuckerberg’s recent announcement regarding the policy change for post moderation on Facebook and Instagram, which aligns these platforms with the same policy adopted by Musk for X/Twitter, I have decided to close my accounts also on those platforms on January 31st.
- After nearly 15 years since its publication, #MANTRA (the tool for drug repositioning I designed during my PhD in Diego di Bernardo's lab at TIGEM) still goes strong! @atulbutte.bsky.social and colleagues using it for drug repurposing in skin inflammation here 👇 👍 www.science.org/doi/10.1126/...
- Reposted by Francesco Iorio🎄🎁 Secret Santa at IorioLab! 🎁🎄 Today, we swapped gifts, laughs, and maybe a few too many inside jokes during our Secret Santa exchange. From creative surprises to hilariously overwrapped packages, everyone brought the holiday cheer 👍 merry Xmas
- Reposted by Francesco IorioAmazing Bavarian-style @humantechnopole.bsky.social CompBiol Centre Xmas Dinner w @bioimagecomputing.com @sottoriva.bsky.social and other labs 🍺🎄👍💻🧬
- Reposted by Francesco IorioDoes my mutation have the same impact as yours? Population genetics 🤠 🥸 🤓 🤡 meets single cell CRISPRi ⚡ ! www.biorxiv.org/content/10.1... Led by Claudia Feng, Oliver Stegle, Britta Velten, @sangerinstitute.bsky.social .
- Reposted by Francesco IorioBluesky is winning because both twitter and threads have gone out of their way to make their platforms inhospitable to reputable journalists and news. @kattenbarge.bsky.social reports: www.nbcnews.com/tech/social-...
- Congratulations Irene and @alessandrodigilio.bsky.social 🥳👍
- 🎓 Huge congratulations to Irene FernandezRebollo and @alessandrodigilio.bsky.social on graduating and successfully defending their master theses on cancer-specific epigenetic clocks! 🧬🕒 Wishing you both great success in your next adventures @manelesteller.bsky.social @humantechnopole.bsky.social
- Reposted by Francesco IorioClearly they tell a very different story! (these are simulated data, not a real screen, as I *randomly* added or subtracted read counts from the two replicates) A paper that describes a screen as reproducible, but shows only the left plot, be wary. Read more here: pubmed.ncbi.nlm.nih.gov/32284587/
- Reposted by Francesco IorioA pair of graphs I think about a lot. On the topic of pooled CRISPR screens, the left is "replicate correlation" when simply examining the abundance of guide RNAs, i.e. log-normalized read counts. On the right is taking those same data and subtracting from a common starting point, i.e. pDNA.
- new publication from the lab of Nereo Kalebic @humantechnopole.bsky.social linking ADD3 to cell morphology and vulnerabilities in GMB, using data from @depmap.org - computational work led by Raffaele Iannuzzi @ioriolab.bsky.social
- 🔬Our Kalebic group with our @francescoiorio.bsky.social Group identified ADD3 as a key gene driving glioblastoma stem cell shape and tumour connectivity, uncovering growth and therapy resistance 📰Published in Life Science Alliance with support from AIRC humantechnopole.it/en/news/canc...
- Reposted by Francesco IorioChildren who develop two independent tumors during childhood are extremely rare We wanted to see if our genomic technologies could shed light into those exceptional cases. Read about it in this recent paper: tinyurl.com/yt9m584d
- Reposted by Francesco Iorio
Look who's here @pnas.org ✔️ @science.org ✔️ @naturecellbiology.bsky.social ✔️ @natrevgenet.bsky.social ✔️ @naturebiotech.bsky.social ✔️ @naturemicrobiol.bsky.social ✔️ @naturechemistry.bsky.social ✔️ @genesdev.bsky.social ✔️ @cellchembiol.bsky.social ✔️ @genomeresearch.bsky.social ✔️ @jcellbiol.bsky.social ✔️ - Reposted by Francesco IorioWant to use bluesky replies as your blog’s comment section? `npm install bluesky-comments` Built by @coryzue.com
- So cool! I just used this to add comments to my site and published an npm package to make it easy for anyone else to do it: www.coryzue.com/writing/blue...
- Reposted by Francesco IorioBluesky has surpassed 22M users.
