Ethan Hughes
neuron-glial interactions, oligodendrocyte lineage, myelin, multi-photon microscopy @CUMedicalSchool
ethanhugheslab.com
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- Reposted by Ethan HughesThrilled to share our new paper @cp-cell.bsky.social: “Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.” This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling. 🔗 www.cell.com/cell/fulltex... Faust et al., Cell 2025
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- Reposted by Ethan HughesOur new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD Thanks to Nina and all of the team!
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- Reposted by Ethan HughesWe had fun assembling images and describing approaches for imaging oligodendrocytes and myelin in vivo, in organotypic slices, and in fixed tissues. This work started in the lab of @jgrutzendler.bsky.social over 10 years ago and continues to keep us busy. www.nature.com/articles/s44...
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- Reposted by Ethan HughesExcited to share this new paper from the lab, now out in @cp-immunity.bsky.social! Led by the talented @bendevlin.bsky.social and in collab with @anneschaefer.bsky.social. a brief 🧵
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- Reposted by Ethan HughesFor those who want a distraction and/ or are interested, here's the latest from the group, led by Phil Braaker www.nature.com/articles/s41...
- Reposted by Ethan HughesOur lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.
- Reposted by Ethan HughesExcited to share this new work led by the talented Mike Dolan @dolan in collaboration with Evan macosko See below for details and preprint
- How does the brain repair myelin after injury? We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination. www.biorxiv.org/content/10.1... Details below 👇
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- Reposted by Ethan HughesInterested in #oligodendrocyte metabolism and/or #multiplesclerosis? Our paper is now at Biorxiv! We show that oligos express MCT2, the high affinity monocarboxylate transporter, well known for supplying neurons with astrocyte-derived lactate (astro-neuron lactate shuttle)👇
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- Reposted by Ethan HughesSo happy we finally published this great piece from Antje Keller @antjekeppler.bsky.social and colleagues on the path forward for FAIR bioimage sharing. www.nature.com/articles/s41...
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- Reposted by Ethan HughesPeer review completed within 7 days! Paying peer reviewers! Yes, it's possible. Fast & Fair peer review by @biologyopen.bsky.social More innovation from @biologists.bsky.social Details here: www.biorxiv.org/content/10.1...
- We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL
- Reposted by Ethan Hughes🚨iGluSnFR4 is finally out!🚨🧪 We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️ www.biorxiv.org/content/10.1... 🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX #Neuroscience
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- This is awesome! Need immunostaining with two rabbit primary antibodies? No problem, with this approach. We will be looking into this more closely. Great to have such careful validation and optimization work with these tools, thank you Horrocks’ lab!
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- Highly recommend!!! Just fantastic to see all the awesome science from my BlueSky community scientists 👩🏼🔬 🧪🔬🧠
- *Please repost* @sjgreenwood.bsky.social and I just launched a new personalized feed (*please pin*) that we hope will become a "must use" for #academicsky. The feed shows posts about papers filtered by *your* follower network. It's become my default Bluesky experience bsky.app/profile/pape...
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- Reposted by Ethan Hughes⭐️ Starterpack for networks and organisations fostering collaborations of glia enthustiasts ⭐️ go.bsky.app/JaGgbrTat://did:plc:z4mbx6koodhfobupypu54457/app.bsky.graph.starterpack/3lk3tg6knon2o
- Reposted by Ethan HughesExcited to finally have this published! Out today in @naturecomms.bsky.social, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. www.nature.com/articles/s41... 1/3
- Reposted by Ethan HughesTODAY IS THE DAY! 🧪☀️⬇️ Join us at the Lincoln Memorial or your local site to Stand Up for Science!
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- Reposted by Ethan HughesDelighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵 Open access link: www.nature.com/articles/s41...
- Reposted by Ethan Hughes🔅📍The Concept of Neuroglia - the State of the Art Circa 1900📍🔅 onlinelibrary.wiley.com/doi/full/10....
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- Reposted by Ethan HughesWe lack tools to rapidly track >1-2 changing signals in brain fluids. Peter Kalugin and an amazing team begin to address this challenge with simultaneous, real-time tracking of many (10+) neuromodulatory signals using Multiplexed Optical Recording of Sensors on a micro-Endoscope. Feedback welcome!
- I’m thrilled to share our preprint presenting MORSE: a new way to simultaneously & quantitatively track patterns of neuromodulators/neuropeptides in vitro & in vivo using spatially multiplexed 3D imaging of 10+ green optical sensors on a microendoscope biorxiv.org/content/10.1101/2025.01.26.634931v1
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- Reposted by Ethan HughesExtremely happy to share our manuscript jointly authored by me and the amazing Lyndsay Osso! An awesome collaboration between the @ethanhugheslab.bsky.social , Dan Denman and Autobahn Therapeutics. www.nature.com/articles/s41... 🧵
- New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠 www.nature.com/articles/s41...
- Reposted by Ethan HughesHi #neuroscience community! This is one of my favorite posts ever. In close collaboration with @liddelowsa.bsky.social and Ye Zhang, we've built a new tool that we are eager to share! www.webseq.net
- Cool new manuscript from the Huang lab!!
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- Reposted by Ethan HughesDid you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction. journals.plos.org/plosbiology/...
- Reposted by Ethan HughesOur lab at Yale U/Wu Tsai Institute has a postdoctoral position on neurodegeneration, neuro-glial-vascular biology using 2photon, calcium/voltage imaging, gene editing,transcriptome/proteome, 3D EM, translational neurosci/chemistry. Email me if interested. Forward to those interested pls
- Cool work on the effects of OPC specific deletion of glucocorticoid receptors! Glucocorticoids target postnatal oligodendrocyte precursor cells to modulate adult hippocampal network plasticity and stress-induced behavior www.biorxiv.org/content/10.1...
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- Reposted by Ethan HughesI am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
