siddhartha jena
buenrostro lab postdoc @ harvard/broad institute. stoked about chromatin, evolution, and bioengineering.
sidujena.github.io
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- Had a great time at #EMBOevoChromo25 learning about some really cool work at the interface of chromatin and evolution. Really an amazing community of scientists! Thank you to all the organizers :) and can't wait for the next one!
- Four days of great science, fun interactions, and breathtaking views at #EMBOevoChromo25 in San Feliu 🇪🇸 BIG THX to organizers @arnausebe.bsky.social @tobiaswarnecke.bsky.social & co @levine-lab.bsky.social @sandraduharcourt.bsky.social Nick Irwin 🙏👌
- Reposted by siddhartha jena1/28 New preprint up, which I think is the best theoretical idea I've ever had. We asked a simple question: what are the costs of investment into non-reproductive somatic cells? Turns out these costs decrease with the *logarithm* of organism size! www.biorxiv.org/content/10.6...
- Reposted by siddhartha jenaConfused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
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A little reading before the Christmas break by the one and only @nucleosomepolice.bsky.social in @annualreviews.bsky.social The expanding Histone universe: Histone-Based DNA organization in noneukaryotic organisms www.annualreviews.org/content/jour... - Phenomenal work!
- Excited to share our new pre-print collab w. @rdaslab.bsky.social Study led by Ved Topkar brilliant MD/PhD student who used biochemistry and bioinformatics to probe the relationship between Mbp mRNA structure & transport/local translation in oligodendrocytes! biorxiv.org/content/10.110… 1/8
- Reposted by siddhartha jenaNew Online! Signal control during tissue regeneration in adult animals
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- As a mammalian-cell bioengineer interested in plants, it was great to connect with Sebastian, and I can assure you you’ll learn a TON from talking to him (if you haven’t already from his posts)
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- Reposted by siddhartha jenaLab’s 1st preprint! Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate. @cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation. He is on the job market!
- I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉 @karalmckinley.bsky.social We built the first transgenic model of menstruation in mice. We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪 www.biorxiv.org/content/10.1... 🧵
- Reposted by siddhartha jenaI adored writing this piece. It brings together several of the things preoccupying me right now, like chromatin organization and gene regulation. There's so much more to be said on that. Also, these marine critters look gorgeous. www.quantamagazine.org/loops-of-dna...
- Reposted by siddhartha jenaGame changer for cell-based plant genetics: the labs of Caixia Gao & Jin-Long Qiu have developed very efficient self-replicating vectors and they just published a very nice proof-of-concept paper. #plantscience www.science.org/doi/10.1126/...
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- This is a great initiative, and would be an invaluable resource to learn more about (and maybe borrow from!) the diversity of cellular organization and regulation across evolution!
- Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...
- very cool image-based screening of HP1 condensates and implications for RNA in regulating mesoscale structures!
- Reposted by siddhartha jenaAsking BlueSky for help: For a review, I am trying to accurately credit the first paper that measured pairwise 3D distances between 2 pieces of DNA on the same chromosome (or cosmid). Is Trask 1989 the first? I know of earlier single-locus papers (1982). www.sciencedirect.com/science/arti...
- Reposted by siddhartha jenaCongrats to my friends in the Boettiger lab for this really beautiful live imaging work. A big leap forward in understanding the dynamic side of genome organization. www.science.org/doi/10.1126/...
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- Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9
- Organisms across the tree of life, including humans, have evolved histone sequences that remodel chromatin in diverse ways. As I learned about these examples, I grew mildly obsessed with the idea of designing histones to do what *I* wanted them to do. 2/9
- Reposted by siddhartha jenaWe traveled to DC to talk to Congressional Staffers about the impact of NIH and NIBIB funding. It enables us to develop synthetic biology tools to advance cell & genetic medicines for patients in need. REPOST to deliver the message that SCIENCE saves lives & makes America GREAT!
- Reposted by siddhartha jenaWhat'd you do over the weekend? Public Works began resurfacing the street in front of the Chipotle where Thomas Paine wrote Common Sense
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- Reposted by siddhartha jenaA must-read for histone afficionados: our new review on 'Histone-mediated chromatin organization in prokaryotes and viruses' www.cell.com/trends/bioch... @samuelschwab.bsky.social @vikramalva.bsky.social
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- Reposted by siddhartha jenaborn too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze
- Reposted by siddhartha jenaOur new preprint is out＠bioRxiv: www.biorxiv.org/content/10.1... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/
- Reposted by siddhartha jena1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social. www.nature.com/articles/s41...
- Check out some awesome new work from my labmate @snaga13.bsky.social on inflammation-induced epigenetic memory!
- Really sad to hear this. I was fortunate to work with Martin as an undergraduate and learned a great deal of chemistry and physics from him, as I’m sure many others did as well.
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- Congrats @toettch.bsky.social and Ileana!
- Reposted by siddhartha jenaI am ***absurdly*** excited to announce the launch of a new funding opportunity through Experiment dot com!!! You have one month to pitch something wonderful in the realm of plant biology/biotech research and education. $10,000 max grant. PLEASE RE-POST + SHARE!!! 1/3 experiment.com/programs/pla...
- Can't wait to try this out - congratulations to the Boltz-1 team!
- Reposted by siddhartha jenaExcited to see our T-cell exhaustion preprint published! This work is led by Tristan Tay and collaborators at AstraZeneca. See the sub-thread (reformatted for bluesky) originally composed and posted by the newly minted Dr. Tay www.cell.com/cell-reports...
- excited to be here and for cool chromatin data to finally outnumber bots on my newsfeed!
