Luca Jovine
Professor of #StructuralBiology @karolinskainst.bsky.social studying #egg-#sperm interaction at #fertilization & #ZonaPellucida (ZP) module proteins
Member of #EMBO & the #NobelAssembly at Karolinska Institutet
More @ http://jovinelab.org
- Thrilled to announce that the GRC Fertilization and Activation of Development and associated GRS will come to Europe for the first time in 2027! Join us in Noordwijk, the Netherlands, 31 July–6 August 2027. Mark your calendars and help us spread the word! #GRC #GRS #Fertilization #Development
- URL for the GRC, which I will have the honor to co-organize together with @jeanjuchung.bsky.social : www.grc.org/fertilizatio...
- URL for the GRS, which will be co-chaired by Sara Pietroforte and Analia Novero: www.grc.org/fertilizatio...
- Excited to attend this #SMART symposium on protein science in impressive Shenzhen!
- Long-awaited OpenFold3 is out!
- Great to get another peek at this story, after hosting @jacob-hanna.bsky.social as keynote speaker of our recent #GRC on Fertilization and Activation of Development!
- 🧪 From petri dish to embryo model: @jacob-hanna.bsky.social work shows how naïve pluripotent stem cells can self-organize into advanced developmental stages. The 2025 #HFSPNakasoneAward lecture reveals the science behind synthetic embryo models. Full lecture 🎥 👉 zurl.co/Tgf4f #sts
- Excited that the Gordon Research Conference on Fertilization and Activation of Development 2025 (and associated GRS) is just a few days away! www.grc.org/fertilizatio... www.grc.org/fertilizatio... #GRC #GRS #fertilization #development #egg #sperm
- It will be an honor to co-chair this #GRC, which has long been my favorite meeting and brings together a fantastic community of researchers working on gamete biology and early development.
- Huge thanks to my partners in crime — Rafael Fissore, @virginiasavy.bsky.social and Shweta Bhagwat — it’s been a real pleasure to shape this program with you over the course of the past two years. Very much looking forward to reconnecting with old colleagues and meeting new ones!
- 👍🎾🇮🇹
- Reposted by Luca Jovine[Not loaded yet]
- Reposted by Luca Jovine[Not loaded yet]
- Thanks @svtnyheter.bsky.social for covering our #ZP2 non-hormonal #contraception story! www.svt.se/nyheter/inri... @ki.se @esrf.fr @pnas.org @vetenskapsradet.bsky.social @kawresearch.bsky.social
- As an old tRNA aficionado, can't help loving this beautiful tour-de-force cryo-EM work on one of nature's coolest molecules! Congrats @sebastianglatt.bsky.social and colleagues!!!
- Changed handle to @jovinelab.org !
- Thanks again @esrf.fr ! www.esrf.fr/sites/www/ho...
- New step taken towards non-hormonal contraception news.ki.se/new-step-tak...
- Fresh off the press in @pnas.org: functional and structural studies of the interaction between #fertilization-blocking mAb IE-3 and mammalian #egg coat protein #ZP2 www.pnas.org/doi/10.1073/... Thanks to @vetenskapsradet.bsky.social @erc.europa.eu @embo.org @kawresearch.bsky.social @dfg.de
- Here we show that a ScFV fragment of IE-3 is sufficient to block #fertilization in vitro, avoiding potential Fc-associated side effects
- Together with the first structural information on a monoclonal antibody bound to a key female #fertilization protein, this paves the way to the development of targeted non-hormonal #contraceptives #StructuralBiology #ReproductiveBiology #AntibodyEngineering #NonHormonalContraception
- Just in time for 8 March, we are thrilled to open the way to targeted non-hormonal contraception with the first structure of a fertilization-blocking antibody bound to a key female reproductive protein, #ZP2: Structural basis of ZP2-targeted immunocontraception www.biorxiv.org/content/10.1...
- And for the other half of the world, have a look at this study by Lu/Ikawa/Tang! Allosteric inhibition of the IZUMO1–JUNO fertilization complex by the naturally occurring antisperm antibody OBF13 www.pnas.org/doi/10.1073/...
- Happy to have played a small part in this nice story on our old friend #endoglin ! Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia www.nature.com/articles/s42... #ENG #preeclampsia #HHT
- ...they were indeed! 😊
- Paper at Cell - ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat - zurl.co/xw7a - Our MiTeGen Loops zurl.co/Q3vm were used to help determine details of IVF-related mechanisms
- Reposted by Luca Jovine
