Álvaro López Codina
Predoctoral Research Assistant at the Llorca lab @cniostopcancer.bsky.social working on mTORC1 signaling and cryo-EM ❄️🔬. Intrigued by the structural mechanisms of protein assemblies involved in endomembrane signaling and trafficking 🧪.
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- Reposted by Álvaro López CodinaRibosome-NAC collaboration: A regulatory platform for cotranslational chaperones, enzymes, and targeting factors. @DeuerlingLab discusses how the NAC coordinates the fate of nascent proteins on the ribosome. dlvr.it/TQnW4n
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- Reposted by Álvaro López CodinaIt’s been fun to put together and write up cryoJAX. Hooray for open-source cryo-EM software! Now it’s time to use it…
- Michael J. O'Brien et al.: CryoJAX: a cryo-electron microscopy image-simulation library in JAX #CryoEM #ImageSimulation #AutomaticDifferentiation @harvard@unewhaven@Cornell...#IUCr journals.iucr.org/paper?S2059798326000550
- Reposted by Álvaro López Codina🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...
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- Reposted by Álvaro López CodinaWe're launching a research lab at SMART. Shenzhen Medical Academy for Research and Translation is a newly established institute with long-term funding mechanisms for internal and external investigators. At full capacity SMART aims to support up to 400 labs. www.scmp.com/news/china/s...
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- Reposted by Álvaro López CodinaNow on bioRxiv: genome‑wide CRISPR KO reveals BAG6 (chaperone) and RNF126 (E3) as core PQC for non‑native missense proteins. VAMP seq. shows >1000 Parkin variants are BAG6 targets, including known pathogenic variants. Work led by Line Pedersen. Collab with @lindorfflarsen.bsky.social
- BAG6 and RNF126 are broadly involved in protein quality control of non-native missense protein variants biorxiv.org/content/10.64898/20…
- Reposted by Álvaro López CodinaCheck out our newest preprint on how the chaperone BAG6 and E3 ligase RNF126 cooperate to target unstable and misfolded missense variants for degradation. Work led by Line Pedersen in @rhp-lab.bsky.social doi.org/10.64898/202...
- Now on bioRxiv: genome‑wide CRISPR KO reveals BAG6 (chaperone) and RNF126 (E3) as core PQC for non‑native missense proteins. VAMP seq. shows >1000 Parkin variants are BAG6 targets, including known pathogenic variants. Work led by Line Pedersen. Collab with @lindorfflarsen.bsky.social
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- Reposted by Álvaro López CodinaCryo-EM and single molecule visualization unravel the role of humancondensin II activation by M18BP1 in driving DNA compaction www.biorxiv.org/content/10.64898/2026.02.02.703226v1 #cryoEM
- Reposted by Álvaro López Codina🧬 #Yeast condensin does more than organize chromosomes. New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins. #YeastResearch #SGD www.yeastgenome.org/reference/S1...
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- Reposted by Álvaro López CodinaRoffay, C., García-Arcos, J. M., Chapuis, P., López-Andarias, J., Schneider, F., ...., Roux, A., & Mercier, V. (2024). Tutorial: fluorescence lifetime microscopy of membrane mechanosensitive Flipper probes. Nature protocols, 19(12), 3457–3469. #EpithelialMechanicsReview buff.ly/mTlcVwn
- Reposted by Álvaro López CodinaGreat to see this officially out: An mTurquoise2-Based Glucose Biosensor - works in yeast & mammalian cells and is compatible with FLIM: pubs.acs.org/doi/10.1021/...
- Reposted by Álvaro López CodinaArnav Saha, Tushar Sherkhane and Nagaraj Balasubramania uncover a mechanosensitive pathway linking ECM stiffness to Golgi organisation and function in breast cancer cells. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...
- Reposted by Álvaro López CodinaIs cortical actin the sole driver of cellular membrane bleb expansion? Junichi Ikenouchi and colleagues implicate also calcium-dependent CaMKII supercomplex reorganization, generating local osmotic pressure to cause water influx for bleb growth link.springer.com/article/10.1...
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- Reposted by Álvaro López CodinaNature research paper: PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling go.nature.com/4klvMp1
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- Reposted by Álvaro López CodinaNew preprint from the lab! We identify the ZnF protein Mulberry as a condensation-dependent structural regulator of genome topology that organizes “multi-way regulatory hubs” in early Drosophila embryos. www.biorxiv.org/content/10.6...
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- Reposted by Álvaro López CodinaThe #mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to #mitochondria. From Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. rupress.org/jcb/article/... 📕 In #Autophagy 2026 👉 rupress.org/jcb/collecti... #KSAutophagy26
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- Reposted by Álvaro López CodinaCollaboration is essential to scientific progress. In our latest issue: www.cell.com/molecular-ce..., we present a focus issue centered around the theme of collaboration, to highlight and celebrate the importance of collaboration in scientific research.
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- Reposted by Álvaro López CodinaSelective proteasomal degradation from the Golgi apparatus membrane biorxiv.org/content/10.64898/20…
- Reposted by Álvaro López CodinaA new paper reports a “nucleotide code” that coordinates Lis1-dynein binding stoichiometry, which in turn governs Lis1’s ability to relieve dynein autoinhibition www.nature.com/articles/s41...
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- Reposted by Álvaro López Codina"Single-molecule dynamics of the #TRiC #chaperonin system in vivo" is out @nature.com. ❕Publication: www.nature.com/articles/s41... ❕Press Release: www.biochem.mpg.de/live-broadca... Authors: @rongqinxiaoxiao.bsky.social, @niko-dalheimer.bsky.social, @mamueller.bsky.social, F.-Ulrich Hartl
- Reposted by Álvaro López CodinaOur paper on how calcium controls lamellipodial actin assembly is out in Current Biology! Huge congrats to Ernest Iu, Alex Bogatch, and all the authors - fantastic collaboration! www.sciencedirect.com/science/arti...
- Reposted by Álvaro López CodinaATG9A facilitates closure of mammalian autophagosomes. From Ruheena Javed, Vojo Deretic and colleagues: rupress.org/jcb/article/... 📕 Part of #Autophagy 2026 👉 rupress.org/jcb/collecti... #KSAutophagy26
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- Reposted by Álvaro López CodinaI’m excited to share my first-author paper, with co-first author @rongqinxiaoxiao.bsky.social, now out in @nature.com. We developed a live-cell single-particle tracking platform to see how TRiC & prefoldin engage proteins during co- and post-translational folding. 1/9 www.nature.com/articles/s41...
- Reposted by Álvaro López CodinaI'm thrilled to share our new publication, with co-first author @ Niko Dalheimer, is now out on Nature. Check out how we use live cell single particle tracking to study real time dynamics between TRiC chaperonin system and it substrates in the crowded cellular environment.
- I’m excited to share my first-author paper, with co-first author @rongqinxiaoxiao.bsky.social, now out in @nature.com. We developed a live-cell single-particle tracking platform to see how TRiC & prefoldin engage proteins during co- and post-translational folding. 1/9 www.nature.com/articles/s41...
- Reposted by Álvaro López CodinaUnleashing live-cell imaging for the masses! Adapting the OpenFlexure Microscope for Affordable Live-Cell Imaging www.biorxiv.org/content/10.6... Fits into existing incubators for time-lapse experiments & feeds into existing bioimaging analysis pipelines. Thanks @wellcometrust.bsky.social funding
- Reposted by Álvaro López CodinaThe orientation of cholesterol's hydroxyl group affects its membrane dynamics and intracellular transport biorxiv.org/content/10.64898/20…
- Reposted by Álvaro López CodinaNutritional Access Modulates Activity of a Small Molecule Enhancer of Endosomal Escape biorxiv.org/content/10.64898/20…
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