Inigo Martincorena
Scientist. Group leader at the Sanger Institute, Cambridge UK. Somatic mutation and selection in normal tissues, cancer and ageing.
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- Reposted by Inigo MartincorenaWhat causes bladder cancer initiating mutations? Our paper in Science Advances asks the question: can BK virus infections of normal urothelium lead to the APOBEC3 mutational signatures found in bladder cancers? We found that they can!
- A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]
- Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
- Reposted by Inigo Martincorena🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)
- Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
- If you read the preprint, not a lot has changed. But if you didn't, here is a link to the original thread summarising our findings. Since then, NanoSeq has become a workhorse in our lab, unveiling a fascinating landscape of somatic evolution across tissues and diseases. bsky.app/profile/imar...
- Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...
- Reposted by Inigo MartincorenaNow published! Our paper on: (1) Accurate sequencing of sperm at scale (2) Positive selection of spermatogenesis driver mutations across the exome (3) Offspring disease risks from male reproductive aging [1/n] www.nature.com/articles/s41...
- I am speaking at #AACR25 this afternoon on our latest work on somatic mutations in normal tissues. If you are attending AACR, feel free to drop by and say hello. brnw.ch/21wRUZZ
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- If you are looking for an exciting postdoc position, please see below! Adrian Baez Ortega (a former member of the group) is starting an independent group at the University of Cambridge on the evolution of transmissible cancers and is recruiting. tinyurl.com/pdra-cambridge
- Reposted by Inigo MartincorenaThe stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our @nature.com paper: www.nature.com/articles/s41...
- Reposted by Inigo MartincorenaExcited to share our new preprint demonstrating somatic rescue mutations in a genetic liver disease! [1/12] www.nature.com/articles/s41...
- Reposted by Inigo MartincorenaDelighted to share a major update on our work investigating age-related deceleration in clonal haematopoiesis. Takehome: Widespread and substantial deceleration in fitness with age! Amazing effort by PhD student Hamish MacGregor 💪 www.biorxiv.org/content/10.1...
- Reposted by Inigo MartincorenaDelighted to share my PhD thesis work is now published in @nature.com! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynmics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis www.nature.com/articles/s41...
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- A nice article covering some of the surprises in the field of somatic mosaicism in the last decade. As I say there: "Judging by the discoveries that we are making at the moment, the journey has only just started. I expect many surprises in the next few years." knowablemagazine.org/content/arti...
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- Quotient Therapeutics is looking for a new Head of Target Discovery, reporting to Peter Campbell, its new CSO. Lots of exciting somatic genomics in this role. uk.linkedin.com/jobs/view/he...
- Reposted by Inigo MartincorenaThrilled to share our latest work on cutaneous T cell lymphoma. Check it out👇🏼 www.nature.com/articles/s41...
