Christoph Handschin
Researcher @biozentrum.bsky.social of @unibasel.bsky.social in 🇨🇭. Skeletal #muscle plasticity / #exercise / #neuromuscular diseases / #aging / #metabolism / #PGC-1alpha
biozentrum.unibas.ch/handschin
- Were you intrigued by our bulk #muscle analysis of acute #exercise and chronic #training published in @natmetabolism.nature.com two years ago? 1/3 doi.org/10.1038/s422...
- Reposted by Christoph Handschin
- Reposted by Christoph HandschinApply now for the prestigious and independent #BiozentrumPhDFellowships. Great science. Unique rotation-based selection of research group and other incentives. The summer call is open until October 12, 2025. bit.ly/4caiqqX @biozentrum.unibas.ch @unibas.ch #fellowship #PhD#Switzerland
- Reposted by Christoph HandschinThe first time Charlie Chaplin used his voice in a film, he wielded it to forcefully condemn the rising forces of fascism around the globe. Will we listen to his words today?
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- From the @apsphysiology.bsky.social @apspublications.bsky.social The Breaking Point: Funding Uncertainty Threatens Scientific Innovation www.physiology.org/publications...
- "Endurance training promotes chromatin closure and timely repression of the post-exercise immediate early stress response" - our new manuscript describes the changes in chromatin accessibility in exercise (acute & training) associated with gene expression. www.sciencedirect.com/science/arti...
- Reposted by Christoph Handschin#OpenAccess: Review from Physiological Reviews, Biomarkers of #aging: from molecules and surrogates to physiology and function Regula Furrer and Christoph Handschin 🖱️doi.org/10.1152/phys... #exercise #healthspan #longevity @unibas.ch
- This just in from @apsphysiology.bsky.social "Early reports indicate that the Trump administration’s proposed FY 2026 budget would slash funding for the NIH by more than 40%, cutting the budget from $47 billion to $27 billion. The APS urges Congress to reject this catastrophic proposal..."
- Now out in the typeset, final version! #openaccess "Biomarkers of aging: from molecules and surrogates to physiology and function" @apspublications.bsky.social @apsphysiology.bsky.social @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch doi.org/10.1152/phys...
- "This moment calls out for moral clarity and resolve. It asks universities to take their mission in society seriously and to resist being co-opted by government forces." @arstechnica.com arstechnica.com/culture/2025...
- What the is early stress response in exercised #muscle for? At least for Klf5, this seems important to shape lipid homeostasis in the acute (fatty acid metabolism) and chronic (lipid synthesis) settings. All this and more in our new paper: #myoblue www.sciencedirect.com/science/arti...
- Our magnum opus on everything related to #aging is out as a preprint in Physiological Reviews @apspublications.bsky.social @apsphysiology.bsky.social #openaccess. Great collaboration with @regula-furrer.bsky.social @biozentrum.unibas.ch @unibas.ch. doi.org/10.1152/phys... Some teasers: 🧵 1/9
- 1.) What is aging? An inevitable normal biological process? A disease that can be treated or even cured? In any case, aging is one of the strongest risk factors for many (mostly chronic diseases), e.g. #cancer, #neurodegeneration and #dementia, or #cardiovascular pathologies. 2/9
- Reposted by Christoph HandschinMike spotted this before the rest of us. 🫡 Publications from 2025 are shared more on Bluesky than on X/Twitter.
- About to talk to medical affairs colleagues, with the news that Bluesky is carrying more posts about new journal publications than X #bluesky #altmetrics #x #xparrot
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- What are good #biomarkers of #aging? Exciting data on plasma proteomics, epigenetic clocks and other molecular parameters might supplement existing biomarkers of health, morbidity and mortality in the future. However, at the moment, good clinical data from large and heterogeneous... 1/3
- Our new paper on #metabolism in #dysferlinopathies / #LGMD2B is out! Why is restoration of membrane repair insufficient to improve disease pathology? Possible explanations in this paper by @regula-furrer.bsky.social and colleagues @biozentrum.unibas.ch @unibas.ch doi.org/10.26508/lsa... 1/4 🧵
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- This is not only an American problem! www.thelancet.com/journals/lan...
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