Oscar Silva
- Reposted by Oscar SilvaDeconstructing empirical fitness seascapes across scales of granularity biorxiv.org/content/10.64898/20…
- Me pregunto qué pensaría Susumu Ohno de que los eventos más antiguos que podemos rastrear mediante métodos filogenéticos sean procesos de duplicación génica.
- What happened before the last universal common ancestor? Pre-LUCA evolution is hard to study. In our new Cell Genomics Perspective we spotlight how paralogous proteins open a window onto the deepest chapters of evolution. 🧬🌍 Out today! --> www.cell.com/cell-genomic... @cellpress.bsky.social
- Reposted by Oscar SilvaWhat happened before the last universal common ancestor? Pre-LUCA evolution is hard to study. In our new Cell Genomics Perspective we spotlight how paralogous proteins open a window onto the deepest chapters of evolution. 🧬🌍 Out today! --> www.cell.com/cell-genomic... @cellpress.bsky.social
- Reposted by Oscar SilvaIn #GENETICS, a new model developed by @christianlandry.bsky.social and colleagues examines how molecular dominance determines total protein activity and contributes to phenotypic dominance. buff.ly/CfaTDp7
- Entre más me entero del intercambio que varios académicos tuvieron con Epstein, más ganas tengo de bombardear todos los rastros que queden de todo aquello que se hacía llamar "la tercera cultura".
- Reposted by Oscar SilvaThe genetic foundations of convergent traits www.nature.com/articles/s41... (free: rdcu.be/e2bBO) 🧬💻🧪
- Reposted by Oscar SilvaRegistrations are now open for the course on #NetworkAnalysis in #SystemsBiology with R/ @bioconductor.bsky.social with @almeidasilvaf.bsky.social www.physalia-courses.org/courses-work... #Rstats
- Reposted by Oscar SilvaPERSPECTIVE: The evolutionary potential of symbiosis Is symbiosis is a source of innovation? Which evolutionary mechanisms could explain how symbiosis drives or hinders innovation? @treyjscott.bsky.social doi.org/10.1093/jeb/...
- Reposted by Oscar SilvaEvery estimand needs an estiplan - lecture A05 of Statistical Rethinking 2026. Total and direct effects, posterior predictions and causal contrasts, sermon about model assumptions and strength of inference. Next week is a back-alley intro to do-calculus. github.com/rmcelreath/s...
- Reposted by Oscar SilvaPassioned by #bioenergetics? Do not miss our new article on the evolutionary history of oxidoreductases with G. Borrel and @sgribaldo.bsky.social @archaeal.bsky.social @valdeanda.bsky.social @pasteur.fr @cnrs.fr @cnrsbiologie.bsky.social @natecoevo.nature.com (www.nature.com/articles/s41...).
- Reposted by Oscar SilvaSlim 5 can now simulate genomes with multiple chromosomes like autosomes, sex chromosomes, mitochondria and chloroplast dna academic.oup.com/mbe/article/...
- Reposted by Oscar SilvaNuevo episodio. Va sobre las preguntas que genera el hecho de que Robert Trivers, uno de los grandes biólogos del siglo XX, aparezca en los expedientes Epstein. open.spotify.com/episode/7zdC...
- Reposted by Oscar Silva"There is still life in the old dog." Brian Charlesworth on Fisher's Fundamental Theorem in @journal-evo.bsky.social doi.org/10.1093/evol...
- Reposted by Oscar SilvaNew paper by Saskia Wilmsen and me just came out BioEssays: A new classification framework to understand evolutionary transitions in individuality Please find the OA paper here: onlinelibrary.wiley.com/doi/10.1002/...
- Reposted by Oscar Silva
- Reposted by Oscar SilvaNEW PAPER with @arvidagren.bsky.social and Manus Patten on evolutionary reversions in individuality now out (as an advance article) at @jevbio.bsky.social (see academic.oup.com/jeb/advance-...). Thread below! [1/8] .
- Reposted by Oscar SilvaCheck out our new review in Nature Reviews Genetics on de novo emerged genes and proteins. How they emerge, are lost and persist - and how de novo emerged proteins relate to randomized proteins! @bornberglab.bsky.social www.nature.com/articles/s41...
- New review out in Nat Rev Genet: Emergence & evolution of protein-coding de novo genes by Erich and Lars Eicholt @lacholt.bsky.social. How non-coding DNA becomes translated, persists or is lost in populations, and can yield structured/functional proteins—plus methods & open questions! rdcu.be/e09SM
- Reposted by Oscar SilvaA new extreme of meiotic evolution: ✔️ 𝗻𝗼 crossovers ✔️ 𝗻𝗼 gene conversion ✔️ 𝗻𝗼𝗿𝗺𝗮𝗹 meiosis & fertility Sex mimics clonality without becoming asexual, in the holocentric multicellular eukaryote 𝘙𝘩𝘺𝘯𝘤𝘩𝘰𝘴𝘱𝘰𝘳𝘢 𝘵𝘦𝘯𝘶𝘪𝘴. more about it: www.biorxiv.org/content/10.6...
- Reposted by Oscar SilvaThe evolution of genetic drift over 50,000 generations biorxiv.org/content/10.64898/20…
- Reposted by Oscar SilvaEveryone should read the Spandrels paper. But too often it's discussed without context of the other contributions. Esp. Clutton-Brock & Harvey on how the comparative method can be used to test adaptive hypothesis, and Cain’s final critique (which SJG called “tame” compared to the oral remarks).
- Gearing up to teach my grad Theory class again, I am reminded that the Spandrels of San Marcos is not a good paper. dynamicecology.wordpress.com/2011/08/26/w... (but I'll probably assign it anyway, for precisely this reason)
- Reposted by Oscar Silva
- Reposted by Oscar SilvaSome science for some sanity: A Beginner's Guide to Structural Variants in Eco-Evolutionary Population Genomics onlinelibrary.wiley.com/doi/10.1111/...
- Dada la situación con Estados Unidos, sería muy bueno que la selección mexicana renunciara a participar en el mundial por mero acto de solidaridad; pero dudo mucho que eso vaya a ocurrir. Lo que también dudo mucho que vaya ocurrir es que la selección pase a los octavos de final.
- Reposted by Oscar Silva"This suggests that these noncoding elements adhere to the CNE model (22, 70), which predicts that novel functionalities evolve without any direct impact on the fitness of the individual." www.science.org/doi/10.1126/...
- Reposted by Oscar SilvaEl pasado 11 de enero fue nuestro quinto aniversario haciendo podcast y sólo les podemos decir que es una labor que nos ha cambiado la vida. Les invitamos a celebrar con nosotros, transmisión en vivo mañana 26 de enero a las 7: 30 pm en nuestros canales habituales. #CultivamosMemorias
- Reposted by Oscar Silva#Paleontologists are working to pinpoint the dawn of the #dinosaurs. What were the early evolutionary steps that set the stage for the animals’ impressive reign? A PNAS News Feature: ow.ly/q3wC50Y1LmI #Lewisuchus #Triassic #Silesaurus #ornithischians #extinction
- Reposted by Oscar Silva1/2 Want to become up to date with pangenomes and genome graphs and their history? Check out this fantastic review by @zbao.bsky.social! Complexity welcome: Pangenome graphs for comprehensive population genomics #pangenomes #plantscience #genomegraphs www.cambridge.org/core/journal...
- Reposted by Oscar SilvaNew paper with @smishra677.bsky.social! How many different trees can be generated by just one duplication event? It turns out A WHOLE LOT, if you consider the coalescent process. 1/ www.biorxiv.org/content/10.6...
- Reposted by Oscar SilvaJoin our KLI Colloquium: "O Theory Where Art Thou? The Changing Role of Theory in Theoretical Biology in the 20th Century and Beyond" Speaker: Jan BAEDKE (Ruhr University Bochum) 🕒 26 Jan 2026, 3:00 PM CET 🗺️ at KLI, join online via ZOOM (link & info: www.kli.ac.at/content/en/e...)
- Reposted by Oscar SilvaCheck out our latest Special Section guest edited by @mitopozzi.bsky.social and Sophie Breton: Beyond ATP: New insight into mitochondrial function and evolution 🎨 Cover image - artwork by Iain G Johnston academic.oup.com/jeb/pages/be...
- Reposted by Oscar SilvaOn the other side, we have the Genomics Adventure, with Guy Leonard (@guyleonard.bsky.social) 🤩🧬💻 A tutorial that anyone can try at home! 🙆🏻♀️ Link: share.google/Tkfu8Ji6WaCJ... #evomics2026
- Reposted by Oscar Silva
- Reposted by Oscar Silva📱Is the origin of animals comparable to the origin of the smartphones? Yes! See our new review in @embojournal.org where we show how important it was the new "Operating System" (animalOS)for animals to evolve! with @ricardsole.bsky.social, Nick and Elena @ibe-barcelona.bsky.social @csic.es @prbb.org
- Reposted by Oscar SilvaThis short book by @djnicholson.bsky.social is extraordinarily good for understanding not just the genesis, message and myths of Schrödinger's book but also why molecular biology developed in the way it did (and what's problematic about that). www.cambridge.org/core/element...
- Reposted by Oscar SilvaOne of the most-viewed PNAS articles in the last week is “The variability of evolvability: Properties of dynamic fitness landscapes determine how phenotypic variability evolves.” Explore now: ow.ly/XouU50XWiiV For more trending articles, visit ow.ly/AiXL50XWi81.
- Reposted by Oscar SilvaPCA is one of those techniques that sounds unreasonable (yeah sure we all want to fit a p-dimensional ellipsoid to our data) but turns out to be a reasonable solution to a wide range of problems. Also: I do hope stackexchange has been archived, because it is my gen's library of alexandria
- still one of the best explanations of principal component analysis (pca), explained at different levels from layman to the more math inclined stats.stackexchange.com/a/140579/132...
- Reposted by Oscar SilvaWhat are the main sources of gene expression noise in bacteria, and why do slower growing bacteria exhibit more expression noise? TLDR: we found growth-rate fluctuations are a key driver of gene expression noise that increase as average growth rate decreases. www.biorxiv.org/content/10.6... 1/n
- Reposted by Oscar SilvaDirected evolution of multimeric proteins is enabled by dual-compensatory gene duplication biorxiv.org/content/10.64898/20…
- Reposted by Oscar Silva"Gene Expression Noise in Development: Genome-wide Dynamics" by Hendrik Marks & colleagues FREE till March 3rd at authors.elsevier.com/a/1mQwocQbJF...
- Reposted by Oscar Silva(and personal ones, too)
- Reposted by Oscar Silvaamerican liberals are fine with millions of deportations as long as they happen quietly and the police don't hurt any white people. proud of it, really
- Reposted by Oscar SilvaSimple case of prebiotic evolution: vesicle populations can respond to selection for greater turbidity via emergent cooperative dynamics biorxiv.org/content/10.64898/20…
- Reposted by Oscar SilvaAlfred Russel Wallace FRS was born #OnThisDay in 1823. He independently conceived of the theory of evolution by natural selection and his work prompted Darwin to publish 'On the Origin of Species'. Wallace laid the foundations of modern biogeography.
- Reposted by Oscar SilvaEvolution isn’t always forward-looking. Experiments show that an early, beneficial mutation can trap E. coli on a local fitness peak, preventing ecotype diversification in structured environments and highlighting the role of G×E interactions. academic.oup.com/evlett/advan...
- Reposted by Oscar Silva📢 A call for papers The journal #GENETICS is calling for paper submissions for a Special Issue on “Fitness Landscapes: data, theory, and applications”. Learn more about research topics that will be covered in the Special Issue:
- Reposted by Oscar SilvaHaller, Ralph & Messer present SLiM 5, a major extension of the SLiM simulation framework for simulating multiple chromosomes, enabling a heightened level of realism for full-genome simulations. 🔗 doi.org/10.1093/molbev/msaf313 #evobio #molbio #compbio
- No digo que México no tenga graves problemas de seguridad, negar la realidad sería una locura; pero conservar esa narrativa del "narco-todísmo" no es más que hacerle el favor al brazo del imperialismo de los EUA. Tenemos la percepción bien alterada sobre la "guerra contra las drogas".
- Recuerdo que años atrás, varios "escépticos" compartían mucho un blog que decía que EUA no estaba interesado en el petróleo de Venezuela, porque los primeros ya habían encontrado formas más eficientes de extraer combustibles fósiles. El blog ya no lo puedo encontrar y es fácil saber por qué.
- Reposted by Oscar SilvaPor cierto, un apunte: No es que las instituciones internacionales que velan por que se cumpla el derecho internacional no estén dispuestas a mover un solo dedo para sancionar estas cosas. Es que no pueden moverlos. Estados Unidos tiene poder para vetar hasta un pestañeo inapropiado.
- Reposted by Oscar SilvaEEUU está atacando a Venezuela. Fuera el yanki de América Latina. No más sangre por petróleo. Fuck Trump.
- Reposted by Oscar Silva"Fuertes explosiones y ruidos similares a los de aviones sobrevolando la zona se produjeron alrededor de las 02:00 horas de este sábado en Caracas, constataron periodistas de la Afp en la capital venezolana." #venezuela #caracas #trump www.jornada.com.mx/noticia/2026...
- Reposted by Oscar SilvaNUEVO VÍDEO Desmontando las mentiras de Israel: la raíces del sionismo LINK youtu.be/p4iRnR9-b6U
- Reposted by Oscar SilvaReturning the page proofs for my quantitative biology textbook, out in February: www.routledge.com/Quantitative...
