Ylva Ivarsson
Professor of Biochemistry, Uppsala University. Views are my own.
Protein domains, disorder and interactions.
- Reposted by Ylva IvarssonWe will take a break for February and return on March 9 at 3pm CET. Tune in with Dr Benjamin Maier (@bdmaier.bsky.social), Valeria Bica and Dr Aleksandra Panfilova Register to attend: tinyurl.com/PMCseminar2 Previous seminars: www.youtube.com/@PMCModularity
- Reposted by Ylva IvarssonIDPSeminas is back again TOMORROW! Talks from Lucia Strader (@luciastrader.bsky.social) and Heather Meyer! Sign up at idpseminars.com. Talks start at 1 pm EST / 7 PM CET!! Come learn about transcriptional adaptation and IDRs as environmental sensors and accuators!
- Reposted by Ylva IvarssonUS science after a year of Trump "More than 7,800 research grants terminated or frozen. Some 25,000 scientists and personnel gone from agencies that oversee research." via @nature.com Dark Age 2.0
- Not sure if Trump getting the Nobel Prize medal from Machado is more embarrassing for Trump, Machado, the Norwegian Nobel Committee, or the USA as a country.
- Reposted by Ylva IvarssonThis is such hard news to process. Such an amazing scientist and inspiration for so many of us. www.embl.org/news/embl-an...
- Very much looking forward to the next PMC seminar, featring Benjamin Turk and Giorgia Massacci: www.proteinmodules.org/online-semin...
- We are back on Jan 19 at 3pm CET! Our first seminar for 2026 will feature Prof. Benjamin Turk (@benturklab.bsky.social) and Dr. Giorgia Massacci. Register to attend: tinyurl.com/PMCseminar2 Previous seminars: www.youtube.com/@PMCModularity
- Reposted by Ylva IvarssonEngineered base editors with reduced bystander editing through directed evolution - @geochurch.bsky.social @harvardmed.bsky.social @wyssinstitute.bsky.social go.nature.com/4qmupbv
- Reposted by Ylva IvarssonLast week, we wrapped up our Volkswagen Foundation–funded project with a wonderful final meeting in Uppsala, hosted by Ylva Ivarsson’s group. The photo shows members of our lab together with colleagues from the groups of @ivarssonlab.bsky.social , @hlouchova-lab.bsky.social and Florian Hollfelder.
- Reposted by Ylva IvarssonDon't forget to catch out last seminar of the year on Monday Dec 8!
- Catch our last seminar for the year on Dec 8 at 3pm CET! With Dr. Martin Rennie (@martinrennie.bsky.social), Jamal Fahoum (@hebrewuniversity.bsky.social), and Dr. Boglárka Zámbó (@zbobo2.bsky.social) Register to attend: tinyurl.com/PMCseminar2 Previous seminars: www.youtube.com/@PMCModularity
- Reposted by Ylva IvarssonNew paper “Proteome-wide model for human disease genetics” is now live at Nature Genetics: rdcu.be/eRu7K popEVE (pop.evemodel.org) finds the needles in the haystacks of human genetic variation:
- Reposted by Ylva IvarssonMajor new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Ylva Ivarsson957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are. erc.europa.eu/news-events/...
- Reposted by Ylva Ivarssonprofaff.fr The new ProfAff database is up and running. Although there are still many things to improve, it is a major upgrade.
- Reposted by Ylva IvarssonI have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
- Reposted by Ylva IvarssonCatch our next seminar on November 10 at 3pm CET! You'll see presentations from Prof. Gideon Schreiber (@weizmanninstitute.bsky.social) and Alessandro Lussana (@alussana.bsky.social). Register to attend: tinyurl.com/PMCseminar2 Recordings of previous seminars: www.youtube.com/@PMCModularity
- Reposted by Ylva Ivarsson🚨🚨🚨 Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program. If you're excited about evolution, genomics and biomedical research, this is your DN! 😃 Further info: www.evomg-dn.eu and 👇
- Reposted by Ylva Ivarssonnew preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
- Reposted by Ylva IvarssonDon't forget to catch out next seminar on October 13 at 3pm CEST!
- Tune in to our next seminar on October 13 at 3pm CEST! We’ll hear from Dr. Cris Viéitez (@crisvieitez.bsky.social) and Dr. Patrick Brunner (@humboldtuni.bsky.social). Register to attend: tinyurl.com/PMCseminar2 Recordings of previous seminars: www.youtube.com/@PMCModularity
- Reposted by Ylva IvarssonCan't wait to see you all there!!
- 🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝 📅 June 21-26, 2026 | Les Diablerets, Switzerland 👉 Details & registration: grc.org/intrinsicall...
- Never thought I would say this, but I need a Dane.. novonordiskfonden.dk/grant/postdo...
- Finally out! Thrilled to share our collaboration with @kulathu.bsky.social, @orafurman.bsky.social, and N Davey. We screened auxiliary domains of USP family #deubiquitinases, revealing short linear motifs (SLiMs), contributing to specificity in complex assembly. www.biorxiv.org/content/10.1...
- Reposted by Ylva IvarssonCool project with the Pless lab on disease-associated variants in a membrane protein, NALCN, that needs to be in complex to function. Most of our computational work was done by PhD student Aleks Panfilova.
- After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN: www.biorxiv.org/content/10.1...
- Reposted by Ylva IvarssonTune in to our next seminar on October 13 at 3pm CEST! We’ll hear from Dr. Cris Viéitez (@crisvieitez.bsky.social) and Dr. Patrick Brunner (@humboldtuni.bsky.social). Register to attend: tinyurl.com/PMCseminar2 Recordings of previous seminars: www.youtube.com/@PMCModularity
- Reposted by Ylva IvarssonTo protein designers (and others) The Dept of Chemistry, Lund University & the Wallenberg Initiative for Materials Science for Sustainability is looking for an Assoc Senior Lecturer/Assist Professor in Biomolecular materials with a focus on de novo design and synthesis lu.varbi.com/en/what:job/...
- Reposted by Ylva IvarssonWe are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se). Register to attend: tinyurl.com/PMCseminar2 Recordings of previous seminars: www.youtube.com/@PMCModularity
- Reposted by Ylva IvarssonLeo Tianlai Chen and coauthors present PepMLM, an ESM-2–based protein language model that designs target-specific peptide binders from sequence alone, enabling binding and degradation of disease and viral proteins. www.nature.com/articles/s41...
- Reposted by Ylva IvarssonWe’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠 Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels. Take a look at these four open positions 👇
- Reposted by Ylva IvarssonPredicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3 biorxiv.org/content/10.1101/202…
- Reposted by Ylva IvarssonAnd of course, we could not have done this without NIH funding that has been critical for supporting my students’ training and my career, and for giving us the resources to shed light on some aspects of the molecular basis of human diseases.
- Excited to see this paper out in its final form, and huge congrats to first author Ziyuan (Jason) Jiang just a week before his thesis defense. This work has become an invaluable resource in our lab for SHP2 projects, and we hope it resonates with the whole field. www.nature.com/articles/s41...
- Reposted by Ylva IvarssonVariant characterization in the intrinsically disordered human proteome - here is how we did it using short linear motif prediction, AlphaFold, and experimentation. Check out our preprint: www.biorxiv.org/cgi/content/...
- We are looking for a PhD student in (mostly )wet-lab biochemistry to work on short linear motifs, intrinsically disordered regions, in the context of the Marie Curie network "IDPro". More info an apply here: www.uu.se/en/about-uu/...
- .. more information about the IDPro network here: idpro.elte.hu
- Reposted by Ylva IvarssonDo you have experience in mechanistic modelling of biological systems and want to do a postdoc with an interdisciplinary team on developing Digital Twins for rare disease? We have the job for you! Check it out below - deadline July 13th, online interviews 24th July.
- Your weekly reminder that there is a really fun post @ebi.embl.org in our group in collaboration with Sheriff Rahuman (@biomodels) and Ellie McDonagh (@opentargets) to create Digital Twins for rare disease using multiomics, executable modelling and AI. Join our interdisciplinary team! Deadline 13/07
- Reposted by Ylva IvarssonA major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)
- Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. 🔗 All positions: ki.se/en/about-ki/...
- Reposted by Ylva IvarssonIt's June 20 in New Zealand, which means it's the last day to have your abstract considered for oral presentations at the IUBMB Focussed Meeting on kinases and pseudokinases!
- Check out the view today from the venue—scoping for the IUBMB Focussed meeting on (pseudo)kinases! Abstracts and early bird registrations closes this week! www.ivvy.com.au/event/IUBMB25/ @pseudokinase.bsky.social @iubmb.bsky.social
- Reposted by Ylva IvarssonSequence-based prediction of condensate composition reveals that specificity can emerge from multivalent interactions among disordered regions biorxiv.org/content/10.1101/202…
- Reposted by Ylva IvarssonIn the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out! rdcu.be/eq975
- Reposted by Ylva Ivarsson“The search is on for 25 researchers from around the world in Lund University’s largest ever international recruitment drive. The main focus will be on AI research and other areas in which the University has a strategic focus.” www.lunduniversity.lu.se/article/lund...
- Reposted by Ylva IvarssonNew lab preprint - Delora Baptista tested AlphaFold 2 and 3 for the prediction of structures of host-pathogen interactions and then applied these to study convergence of binding and molecular mimicry in host-pathogen vs. host-host interactions. www.biorxiv.org/content/10.1...
- "Journal name : POSITIF JOURNAL - we can publish papers of all subjects." Very positive indeed.
- Reposted by Ylva IvarssonTIME CHANGE - Because of a public holiday, we have moved the next seminar to Monday June 16 at 3pm CET. Tune in to hear from Dr. Lucía Chemes (@unsamoficial.bsky.social) and Julian van Gerwen (@julianvangerwen.bsky.social). Register to attend: tinyurl.com/PMCseminar2 (1/2)
- Reposted by Ylva Ivarsson[This post could not be retrieved]
- Reposted by Ylva IvarssonIDPSeminars is back with another seminar this week from @sarahshammas.bsky.social and @sonia-longhi.bsky.social! Come hear about transcriptional regulation and viral pathogenesis! Thursday June 5th! PST 10 am EST 1 pm CET 7 pm! Info: idpseminars.com Signup form: forms.gle/3yCHeYvuuqLh...
- When you ask ChatGTP for advices on what not to do you get honest advices 😂 "Avoid becoming a dean or high-level university administrator, it could reduce the ability to do research and publish. While these roles bring influence, they often pull scientists away from the bench and their networks."
- Reposted by Ylva Ivarsson1 plant hormone receptor ☘️ 3,500 mutants, to single-site saturation 🧬 >45,000 binding and abundance measurements 📶 Very happy to present our latest work – where deep mutational scanning meets the world of small molecules. www.biorxiv.org/content/10.1... With @benlehner.bsky.social [1/7]
- Reposted by Ylva IvarssonWe have 2-3 group leader positions opening @fimm-uh.bsky.social !! We are looking for outstanding candidates in human genetics and precision medicine. This time we have a focus on population health data science. E.g. AI for EHR/health data Generous starting package 💰 shorturl.at/FAk6n
- Reposted by Ylva IvarssonWith less than a month to submit abstracts for the @iubmb.bsky.social Focussed Meeting on (pseudo)Kinases in stunning Queenstown, we are delighted to announce travel scholarships for selected ECRs thanks to @biologists.bsky.social and the Maurice and Phyllis Trust! www.ivvy.com.au/event/IUBMB25/
- Reposted by Ylva Ivarsson
- Reposted by Ylva IvarssonJoin us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute.bsky.social) and Dr. Jesús Alvardo Valverde (@jesusav.bsky.social). Register to attend: tinyurl.com/PMCseminar2 (1/2)
- Fabulous day with PhD defense of Dr Konstantinou. Many thanks to the examination committee, the faculty opponent, the #ubimotif #ETN network. Congratulations to the new PhD! Her first first author paper is now online and the second will follow soon. biologydirect.biomedcentral.com/articles/10....
- Reposted by Ylva IvarssonCome and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social Building AI models or the data to train them? Core funding of >$130M a year for a faculty of ~30. www.nature.com/naturecareer... acrobat.adobe.com/id/urn:aaid:... pls RT!
- We uncover that the #USP8 rhodanese domain is a #peptide binding module that binds short linear motifs in potential substrates: biologydirect.biomedcentral.com/articles/10....
- Reposted by Ylva IvarssonWe will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers. As well as ambitious proposals for R&I in the next EU budget. We will also offer the best and brightest the right incentives to come to Europe ↓
- Reposted by Ylva Ivarsson500 million euro budget increase for EU science 2025-2027 including the previously announced extra funding for those moving in and a new 7 year ERC grant (not just for those moving to Europe). I am not sure a new ERC program is needed but at least it does mean a boost to the ERC budget.
- The ERC welcomes the offer of substantial additional budget from @ec.europa.eu for the development of a new ERC funding instrument offering larger, longer-term grants, as announced by President Ursula Von der Leyen at the Sorbonne this morning. 👉 europa.eu/!NTYTTV
- Reposted by Ylva IvarssonIn this evaluation of AlphaFold3 (and other methods), we show that (i) accurate predictions are limited to RNA structures/complexes with structural similarity to PDB and (ii) that current methods are bad at estimating the accuracy of the predictions. www.biorxiv.org/content/10.1...
- Some days are nailing days 👏 - very proud #PhD advisor of Aimiliani Konstantinou. Amiliani has been a #MSCA fellow in the #UBIMOTIF network and will defend her thesis on the elucidation of the short linear motif-based interactions of #DUBs next week at Uppsala University.
- Looking for a senior lecturer (associate #professor) position in #biochemistry? Come and join our neighbouring department at Uppsala University: www.uu.se/en/about-uu/...
- Reposted by Ylva IvarssonThe Structural Biology and NMR Laboratory—or SBiNLab as we call it—is turning 25 🎉🧲🇩🇰 We're celebrating with a symposium on Aug. 23 that is free and open to all Great speakers incl. Ad Bax, Frauke Gräter, Harald Schwalbe, Sarah Shammas, Mikael Akke & alumni! Join us: www1.bio.ku.dk/english/rese...
- Happy to announce the 2025 Tiselius symposium in Uppsala, August 28. Excellent line up of speakers including Lori Passmore @lapassmore.bsky.social, Katja Luck @katjaluck.bsky.social, Markku Varjosalo @varjosal.bsky.social and Arne Elofsson. No fee & short talk slots available tiseliussymposium.org
- Since when is #proofreading about correcting mistakes introduced by the journals' editing systems?
- Reposted by Ylva IvarssonRemember to join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@uoft.bsky.social) and Dr. Veronica Venafra. Register to attend: tinyurl.com/register-pmc-seminar You can find recordings of previous seminars here: www.youtube.com/@PMCModularity
- Join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@uoft.bsky.social) and Dr. Veronica Venafra. Register to attend: tinyurl.com/register-pmc-seminar (1/2)
