Yasuhiro Kadota
Senior Research Scientist @ RIKEN CSRS Plant Immunity Research Group.
I study how plants recognize pathogens and rapidly induce immune responses.
scholar.google.com/citations?user=nd77…
- Huge congratulations to Akira on the launch of a microbial pesticide product! Turning fundamental science into real-world agricultural solutions is remarkable achievement — truly impressive work.
- Reposted by Yasuhiro KadotaWe wrote a review on the mᴏdular properties of plant cell-surface receptors, and how this knowledge can be used to reprogram and engineer them: www.sciencedirect.com/science/arti...
- Well done, Bruno!!!
- We wrote a review on the mᴏdular properties of plant cell-surface receptors, and how this knowledge can be used to reprogram and engineer them: www.sciencedirect.com/science/arti...
- Reposted by Yasuhiro KadotaAnd we’re off with Professor Cecile Segonzac opening Stromlo meeting! #strompath25
- Reposted by Yasuhiro KadotaAnd next up we have @yichangsung.bsky.social from @gittacoaker.bsky.social lab talking about tandem kinases … #strompath25
- Reposted by Yasuhiro KadotaPrivileged to have @yasukadota.bsky.social present at the Stromlo conference on the SCORE receptors … brilliant story. #strompath25
- Reposted by Yasuhiro KadotaPomelo on tatami as the cover of RIKEN Research www.riken.jp/medialibrary...
- Reposted by Yasuhiro KadotaPlant Science Research Weekly -- Discovery and engineering of synthetic RLKs (Science) @shirasulab.bsky.social @brunongou.bsky.social @yasukadota.bsky.social @BrunoNgou (Summary by Mary Williams @PlantTeaching.bsky.social) buff.ly/JlJKjJE #PlantaePSRW
- Reposted by Yasuhiro KadotaWell done, Max! Neofunctionalized RGF pathways drive haustorial organogenesis in parasitic plants | Science Advances www.science.org/doi/10.1126/...
- Reposted by Yasuhiro Kadotathis research is potentially also interesting to botanical industries (herbalist, food, cosmetics, cannabis, etc.) and maybe even to pharma, because a lot of the botanically derived extracts those industries use come from plant immune systems and their structure and function against pathogens.
- Very happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @science.org ! www.science.org/doi/10.1126/...
- Discovery and engineering of synthetic RLKs plantae.org/discovery-an...
- Reposted by Yasuhiro KadotaBIK1-RIN4 complex links plant immunity and pathogen virulence www.biorxiv.org/content/10.1...
- 理研、植物が病原体からの「危険サイン」を検知するセンサーの役割を持つ免疫受容体をさまざまな種から探索する方法を開発 - 日本経済新聞 www.nikkei.com/article/DGXZ...
- Game-changing biotech for engineering pathogen-resistant crops | EurekAlert! www.eurekalert.org/news-release...
- 病原体を見分ける植物のセンサーをデザイン | 理化学研究所 www.riken.jp/press/2025/2...
- Excited to announce that our latest paper has just been published in Science! ttps://www.science.org/doi/10.1126/science.adx2508
- Reposted by Yasuhiro KadotaVery happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @science.org ! www.science.org/doi/10.1126/...
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View full threadReposted by Yasuhiro KadotaWith this approach, we aim to characterize more PRRs against different pathogens & pests in the future.
- Reposted by Yasuhiro KadotaI am very grateful to Michele & Marc, Takehiro & Dohmae-san, Markus, @yasukadota.bsky.social & @shirasulab.bsky.social for their support. Also big thanks to the reviewers and editors for improving our manuscript!
- Reposted by Yasuhiro KadotaRegistrations are rolling in for the 2025 Stromlo Plant Pathology meeting in Canberra (Nov 27–28)! Secure your spot! Speakers: @yasukadota.bsky.social, Cecille Segonzac, @thamlab.bsky.social, @yichangsung.bsky.social, Tek Tay & @danielsyu.bsky.social. Register at tinyurl.com/3e3tx9j2 #strompath25
- Reposted by Yasuhiro Kadota🌱 From Nature Plants: Phosphorylation of NLR immune receptors by a cell wall–associated kinase limits resistosome assembly, fine-tuning plant immune responses. (Savithramma P. Dinesh-Kumar) ▶️ www.nature.com/articles/s41... #PlantBiology #PlantScience
- Reposted by Yasuhiro KadotaOur new work uncovering how WIND1 promotes somatic embryogenesis as a bifunctional chromatic regulator!!!! We knew WIND1 promotes new fate acquisition and now we show WIND1 also helps repressing existing identity!
- WIND1 controls cell fate transition through histone acetylation and deacetylation during somatic embryogenesis biorxiv.org/content/10.1101/202…
- Reposted by Yasuhiro KadotaWIND1 controls cell fate transition through histone acetylation and deacetylation during somatic embryogenesis biorxiv.org/content/10.1101/202…
- Reposted by Yasuhiro KadotaA truly enabling new approach by @taralowensohn.bsky.social Will Cody and @sattelylab.bsky.social to probe plant genetics at scale. Single-gene-per-cell delivery coupled to an effective transcriptional selection system www.biorxiv.org/content/10.1...
- Reposted by Yasuhiro KadotaChitin Soil Amendment Triggers Systemic Plant Disease Resistance Through Enhanced Pattern‐Triggered Immunity - Makechemu - Plant Biotechnology Journal - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...
- 植物が寄生線虫や昆虫を認識するメカニズムを解明しました！ 植物は“危険サイン”により寄生線虫を察知する www.riken.jp/press/2025/2...
- Reposted by Yasuhiro KadotaExciting preprint! CryoEM structure of plant ROS & quinone receptor CARD1 (also known as HPCA1) reveals it is a copper dependent redox sensor (and cys residues not essential). CARD1 is a member of LRR-RLK clade VIII-1. www.biorxiv.org/content/10.1...
- 🎉 Our new paper is out in Science Advances! Plants can detect parasitic nematodes. www.science.org/doi/full/10....
- Reposted by Yasuhiro KadotaHere comes the final version. Congratulations Erika, Yasu, Ken, and all others involved! @yasukadota.bsky.social @shirasulab.bsky.social www.science.org/doi/10.1126/...
- Yasuhiro Kadota @yasukadota.bsky.social from RIKEN, also @shirasulab.bsky.social lab colleague, talks about identification of nematode MAMP and its receptor. Many years of hard work sacrificing bunch of C. elegans in single slide. Not this image
- Reposted by Yasuhiro KadotaExcited this paper is finally published! We focused on the inner concave surface of LRR RKs to expand bacterial flagellin perception in plants. Selection indicates expanded perception is more common than previously thought. Experiments led by @jerrytli.bsky.social www.nature.com/articles/s41...
- Reposted by Yasuhiro KadotaCryo structure of CARD1 from N. benthamiana transiently produced protein.
- Reposted by Yasuhiro KadotaOur new work lead by Anuphon. Cryo Structure of CARD1 reveals copper in the ecodomain, required for sensing H202. The phenotype of card1 is same as rbohd, suggesting ROS produced by RBOHD is sensed by CARD1.
- Reposted by Yasuhiro KadotaBTW, he is not my PhD student.
- Reposted by Yasuhiro KadotaI'm very happy that this paper is now published in PNAS! Isochorismate-based salicylic acid biosynthesis appears to have emerged in the Brassicales after the divergence of C. papaya, likely within the timeframe between the divergence of B. maritima and R. odorata. www.pnas.org/doi/10.1073/...
- Reposted by Yasuhiro KadotaSongyuan Zhang - what can we learn from natural variation that can inform receptor engineering? Combined observed sequence variation with AlphaFold3 prediction to model and engineer the pattern recognition receptor FLS2, and then the pathogen peptide agonist flg22. #2025ISMPMI
- Reposted by Yasuhiro KadotaIf you are enjoying #2025ISMPMI then you might also be interested in joining the Plant Peptide and Receptor Meeting #PPRM2025, 8th-10th September in Edinburgh. We have a great lineup of speakers and a diverse and inclusive community. More info here pprm2025.events.kdmeventsportal.co.uk
- Reposted by Yasuhiro Kadota
New preprint! 📑@danimstevens.bsky.social led the development of mamp-ml, a machine learning protein language model approach to predict functional outcomes of immune receptor - microbial peptides interactions. mamp-ml performs better than AlphaFold2 I will talk about it Thr 10:10-10:30 #2025ISMPMI- #2025ISMPMI 📣 In silico screening of PRR-epitope interactions is now possible! Here, we developed mamp-ml to predict their immunogenic outcomes without structural context. Let's accelerate engineering plant receptors for robust resistance! 🚀🌱 Small 🧵 www.biorxiv.org/content/10.1...
- Reposted by Yasuhiro Kadota#2025ISMPMI has been great, so many connections made and re-established. I found this on the railway bridge.
- Reposted by Yasuhiro KadotaThe original works: SYR2-SYR1: Zhou et al 2025, Dev Cell www.sciencedirect.com/science/arti... DM3/DM2: Wan et al 2025, Mol Cell www.cell.com/molecular-ce...
- Reposted by Yasuhiro KadotaSecond, work from Eunyoung Chae on autoimmunity mediated by the NLR DM2 and DM3 "Dangerous mix". CryoEM structures show a shift in enzyme hexamer stability to be the allele-specific trigger for DM2. We highlight that Alphafold can't predict this structural shift. www.cell.com/molecular-ce...
- Reposted by Yasuhiro KadotaWe recently wrote two Preview articles of exciting MPMI papers in Mol Cell and Dev Cell. Two surprising cases showing different ways to regulate immune receptors in plants -- the cell surface LRR-RK, SYR1 and the intracellular NLR DM2 Short summaries below 🧵🌱 #2025ISMPMI
- Reposted by Yasuhiro KadotaAre you interested in receptor kinase signalling and plant immunity? We have several positions open to join our team at @thesainsburylab.bsky.social in Norwich. #plantscience #mpmi #plantimmunity #sceincejobs Please get in touch if you have questions 1/5
- Reposted by Yasuhiro KadotaRiyohei Thomas Nakano (@luckystrike1984.bsky.social) is presenting new work about the mechanisms of disease suppressive microbes. Have identified AhcY mutant and looking into downstream effects. #2025ISMPMI
- Reposted by Yasuhiro KadotaYasuhiro Kadota @yasukadota.bsky.social from RIKEN, also @shirasulab.bsky.social lab colleague, talks about identification of nematode MAMP and its receptor. Many years of hard work sacrificing bunch of C. elegans in single slide. Not this image
- Reposted by Yasuhiro KadotaPredicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3 biorxiv.org/content/10.1101/202…
- Reposted by Yasuhiro KadotaThis is textbook cell biology material by chin-hang Wu and colleagues . Check it out 👇 #plantsci #plantpath #immunology #NLRbiology www.biorxiv.org/content/10.1...
- Reposted by Yasuhiro Kadota🌱 Excited to announce the Plant Peptide Receptor Meeting will take place in Edinburgh, 8–10 Sept 2025 #PPRM2025 Focusing on the latest research on plant peptides & receptor kinase signalling. ⏳Early bird registration closes in just 2 weeks! 🔗 pprm2025.events.kdmeventsportal.co.uk#countdown
- Reposted by Yasuhiro KadotaI like this work! A synthetic jasmonate receptor agonist uncouples the growth–defense trade-off in rice www.pnas.org/doi/abs/10.1...
- Reposted by Yasuhiro KadotaThrilled to share our new paper in @science.org describing our discovery that bacteria can switch from competitors to bonafide predators when resources run dry—arming nanoscale “spears” (T6SS) to stab & consume neighbours. www.science.org/doi/10.1126/... #MicroSKy #Microbiology
- Reposted by Yasuhiro KadotaLatest paper from the lab @eveteyssier.bsky.social @malick-mbengue.bsky.social @melaniekrich.bsky.social @pierremarcdelaux.bsky.social et al. just out @pnas.org : 1) Plants have used LysM-RLK receptors for 450 million years to dialog with symbionts, and 2) CO/LCOs might not be that essential
- I’m very happy that my main PhD work, under the supervision of @malick-mbengue.bsky.social, found a home in @pnas.org Two days before my PhD defence! 🎉 (1/6)
- Reposted by Yasuhiro KadotaNew alleles of Arabidopsis BIK1 reinforce its predominant role in pattern-triggered immunity and caution interpretations of other reported functions www.biorxiv.org/content/10.1...
- Reposted by Yasuhiro KadotaTwo exciting papers from Shirasu Lab utilizing the *juice* of my favorite biological players—Agrobacterium and nematodes—to investigate receptor profiles! 🦠 www.biorxiv.org/content/10.1... 🪱 www.biorxiv.org/content/10.1... Congrats to the authors! 🥳🤩
- Reposted by Yasuhiro KadotaHappy to announce that registration for the 2025 Stromlo Plant Pathology (and plant pests!) conference at ANU is now open (Nov 27-28). Plenary speakers confirmed include @yasukadota.bsky.social, Cecile Segonzac and@thamlab.bsky.social. Please go to tinyurl.com/2rdxuap3 to register - all are welcome!
- Reposted by Yasuhiro KadotaJoin us for the 🪴 🌵 Plant Peptide Receptor Meeting 2025 ☘️ 🪴 in 🏴 Edinburgh 🏴 8th-10th September #plantsignaling #PlantScience #plantsci pprm2025.events.kdmeventsportal.co.uk @pprm2025.bsky.social A thread 🧵 (1/n)
- Reposted by Yasuhiro KadotaRep1 vs. Lep1? …for Japanese speakers nph.onlinelibrary.wiley.com/doi/full/10....
- Reposted by Yasuhiro KadotaSTT3A is required for recognition of pathogen-derived sphingolipids in Arabidopsis biorxiv.org/content/10.1101/202…
- Reposted by Yasuhiro KadotaCongratulations to Uta Paszkowski from @cropscicentre.bsky.social - elected to the National Academy of Sciences, USA in recognition of her significant contributions to understanding symbiotic relationships between plants & fungi. @cambridgebiosci.bsky.social @paszkowskilab.bsky.social
- Reposted by Yasuhiro KadotaVery happy to see my friend Uta Paszkowski from @cropscicentre.bsky.social elected to @nasonline.org. Improved plant-microbe symbioses are a key puzzle piece in the fight against the #climatecatastrophe (yes, it hasn’t gone away). www.cropsciencecentre.org/staff/uta-pa...
- Reposted by Yasuhiro KadotaStory behind our recent paper on tandem kinases is out! Written by @yichangsung.bsky.social. #MPMI #PlantBiology www.nature.com/articles/s41...
