Bruno Ngou
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- We wrote a review on the mᴏdular properties of plant cell-surface receptors, and how this knowledge can be used to reprogram and engineer them: www.sciencedirect.com/science/arti...
- Plant cell-surface receptors regulate diverse biological processes. They perceive a wide range of ligands via distinct ectodomainꜱ, then assemble into different receptor/co-receptor complexes to activate downstream responses.
- The receptor ectodomain is primarily involved in ligand perception. By swapping ectodomains or modifying them in different ways, we can զuickly reprogram receptors to perceive new ligands.
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View full threadMany thanks to the editors for the invitation. Free access tᴏ the article: authors.elsevier.com/a/1mIlz3PtAV...
- Very happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @science.org ! www.science.org/doi/10.1126/...
- A🧵of the full story here: bsky.app/profile/brun... Below is an illustrative summary:
- First post on Bluesky!! ☀️ Very happy to share that my main postdoc work ‘Systematic Discovery and Design of Synthetic Immune Receptors in Plants’ is finally out on Biorxiv! www.biorxiv.org/content/10.1... The full story is summarized here:
- To characterize immune receptors (PRRs) in plants, we cluster PRRs into subgroups based on conservation of their inner LRR residues. We obtained >1000s subgroups with this approach, and cloned ~210s into receptor chimeras for further characterization.
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View full threadI am very grateful to Michele & Marc, Takehiro & Dohmae-san, Markus, @yasukadota.bsky.social & @shirasulab.bsky.social for their support. Also big thanks to the reviewers and editors for improving our manuscript!
- First post on Bluesky!! ☀️ Very happy to share that my main postdoc work ‘Systematic Discovery and Design of Synthetic Immune Receptors in Plants’ is finally out on Biorxiv! www.biorxiv.org/content/10.1... The full story is summarized here:
- Many organisms use pattern-recognition receptors (PRRs) to detect pathogens. Plants also utilize cell-surface PRRs to defend themselves. ↑pressure from pathogens drives the expansion of immune receptor repertoires in genomes, leading to lineage-specific PRR diversification (I)
- Here's an example with LRR-RLK-XII, one of the largest PRR families in plants. Compared to the favorite plant model organism, Arabidopsis thaliana (with only 10 LRR-RLK-XIIs), genomes of perennial trees and polyploid species possess hundreds of LRR-LRK-XIIs (II)
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View full threadThis has truly been one of my fav projects. Huge thanks to Michele & Marc, Takehiro & Dohmae-sensei for the bioinformatic & MS support, @yasukadota.bsky.social & @shirasulab.bsky.social for their unwavering support & belief in me & this project. Hope you enjoyed the thread & happy to discuss!
