Alex Gitlin
Assistant Member/Professor, Lab Head @MSKCancerCenter. #PhysicianScientist #Immunologist. Views my own.
- Reposted by Alex GitlinNYers helps us call on @governor.ny.gov to invest in the Empire Biomedical Research Institute. A robust, stable research ecosystem protects jobs, fuels innovation, and builds community health. NY must invest in our global leadership in science. nycures.org @gothamist.com: tinyurl.com/5fab5k7u
- Reposted by Alex GitlinIndependent mechanisms of inflammation and myeloid bias in VEXAS syndrome @nature.com @gitlinlabmsk.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...
- 🚨Thrilled to share our latest work, published online today @nature.com in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort @mskcancercenter.bsky.social led by superstars Varun Narendra + @tandriladas.bsky.social 1/ www.nature.com/articles/s41...
- The story begins in Dec 2020, when a group at NIH discovered somatic mutations in UBA1 - initially all at Met41 - in 25 patients with an undiagnosed inflammatory/hematologic disorder. A real shock as UBA1 is the major E1 enzyme in the ubiquitylation cascade! 2/ pubmed.ncbi.nlm.nih.gov/33108101/
- Fast forward several years, and what's emerged is that this unusual disease termed VEXAS syndrome for its cardinal features has an estimated prevalence as high as ~1 in 4,000 males over 50 3/ pubmed.ncbi.nlm.nih.gov/36692560/
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View full threadAlso thanks to Ian Demsky @mskcancercenter.bsky.social for this fantastic article on our paper: www.mskcc.org/news/msk-res...
- Reposted by Alex GitlinCongratulations to IMP faculty members Chryssie Brown @chrysothemisbrown.bsky.social and Alex Gitlin @gitlinlabmsk.bsky.social on receiving the 2025 Pershing Square Prize!! 🎉
- Reposted by Alex GitlinHow do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!
- Reposted by Alex GitlinCongratulations to Dr. Adriana Mujal on this @cp-immunity.bsky.social study demonstrating a new role for an age old cytokine! www.cell.com/immunity/ful...
- Reposted by Alex GitlinAttempting to read the language of B cell and T cell receptor sequences to diagnose immunological diseases: Our new paper, led by the outstanding Maxim Zaslavsky @maximzaslavsky.bsky.social sky.bsky.social with help from me and Anshul Kundaje @anshulkundaje.bsky.social. Link: buff.ly/3QvxSVf
- Reposted by Alex GitlinDeep thanks to our many collaborators and all research participants. #immunology #science 🧪 @science.org @sarahhross.bsky.social NIH funding was the lifeblood of this work, as it is for almost all biomedical discoveries and therapies in the U.S. @niaidnews.bsky.social
- Hi everyone! Our team, the Cell Cyclers, are raising funds this year as part of #cycleforsurvival to support rare cancer research. 100% of donations will go to @mskcancercenter.bsky.social for this cause and are being matched dollar for dollar today! 🙏To donate: secure2.convio.net/mskcc/site/T...
