A really exciting new preprint out from the Jura and Verba labs looking at conformational dynamics of PI3K on membrane surfaces using cryo-EM. This is truly groundbreaking, and provides a ton of exciting insight into PI3K activation
www.biorxiv.org/content/10.1...
Structures of the PI3Kα/KRas complex on lipid bilayers reveal the molecular mechanism of PI3Kα activation
PI3Kα is a potent oncogene that converts PIP2 to PIP3 at the plasma membrane upon activation by receptor tyrosine kinases and Ras GTPases. In the absence of any structures of activated PI3Kα, the mole...
