John Burke
Professor at the University of Victoria. Structural biologist studying phosphoinositides, membrane signalling, and nanobodies using HDX-MS, x-ray crystallography and cryo EM
- Reposted by John BurkeDo you want to know more about how Retromer regulates Rab7 activity in yeast? Of course you do. Check out the new collaboration with Andreas Mayer with work led by Catarina Alves and Kevin Chen.
- Reposted by John BurkeExcited to share our first collaborative paper of the year- a review on the emerging roles of lipids in flavivirus infection, now published in @cp-trendsmicrobiol.bsky.social. Congrats to Judah (postdoc) for spearheading the work! @ohsunews.bsky.social www.sciencedirect.com/science/arti...
- Have you ever thought about coming to Canada as a researcher? See new programs for established PIs to move to the great north. If you have any questions about possibilities at UVic let me know www.canada.ca/en/impact-pl...
- Reposted by John BurkeIt is a nice way to end the week: our improved RAB GTPase BioID map now online! www.nature.com/articles/s42... We hope it will be useful to the community, and we're happy to share any reagents!
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- Reposted by John BurkeExciting collab with Paul Palme, Peter Imming, & Adrian Richter! Guided by @courbongautier.bsky.social's structure of myco ATP synthase bound to a squaramide, they have made SQAs that are less toxic, more potent, more stable than AstraZeneca's SQ31f #MedChem #TB #NTM pubs.acs.org/doi/full/10....
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- Cool new paper (www.jbc.org/article/S002... from my lab spearheaded by graduate students Sushant @sushantsuresh.bsky.social and Alex @alexlouiseshaw.bsky.social . This was a very cool collaboration with the Scott Hansen, Jennifer Cobb, Tamas Balla labs
- We fully characterised all possible regulatory complexes that can form between all 6 possible combinations of PI4KA regulatory complexes containing EFR3, TTC7 and FAM126 isoforoms
- Reposted by John BurkeA while back we found that the lipid-binding protein PLEKHA4 boosts Wnt/β-catenin signaling and drives melanoma growth in vivo. Now, we (Nathan Frederick) identify small-molecule inhibitors of PLEKHA4 & related proteins with anticancer activity in vitro! pubs.acs.org/doi/10.1021/....
- Just spent an hour trying to get chatgpt to write a custom zotero script for me. Not super worried about AGI coming anytime soon...
- Great visit to the university of torino for a seminar, fun science and great food with good friends
- New review out from my lab on class I PI3Ks www.sciencedirect.com/science/arti..., was fun to write where we are and where we are going in PI3K research Great work from Isobel and Alex in my lab @alexlouiseshaw.bsky.social
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- Reposted by John BurkeHave you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community. Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
- We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime
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- Reposted by John BurkeCheck out the view today from the venue—scoping for the IUBMB Focussed meeting on (pseudo)kinases! Abstracts and early bird registrations closes this week! www.ivvy.com.au/event/IUBMB25/ @pseudokinase.bsky.social @iubmb.bsky.social
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- Reposted by John BurkeSCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web. chemsymposia.com
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- A really exciting new preprint out from the Jura and Verba labs looking at conformational dynamics of PI3K on membrane surfaces using cryo-EM. This is truly groundbreaking, and provides a ton of exciting insight into PI3K activation www.biorxiv.org/content/10.1...
- New work out from my lab by my graduate student Isobel in collaboration with Josh Pemberton and Tamas Balla. Provides some new cool tools to manipulate PI3,5P2 levels, as well as some new insight into PIKfyve regulation. rupress.org/jcb/article-...
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