Prof Amanda J Farrin
Director of Edinburgh Clinical Trials Unit | NIHR Senior Investigator | innovative trials methods | robust development & evaluation of complex interventions | data science for trials
- Reposted by Prof Amanda J FarrinI'm doing a webinar in two weeks (15 Oct 1-2pm BST), part of NIHR Research Support Service's Methods Academy series, on the age-old question: should I do a stepped wedge trial? Free registration, details here: tinyurl.com/z6cjvce3 @nihr-rss.bsky.social @wiphcem.bsky.social @qmul-wiph.bsky.social
- Reposted by Prof Amanda J FarrinGreat to have so many engaged people in the room! More workshops are planned for 2026. Follow us here and on LinkedIn find out about future training opportunities. www.linkedin.com/company/ukcrc-registered-ctu-network/ #UKCTUNetwork #HTBAGCI #ClinicalTrials
- Yesterday GCTU hosted the UKCRC "How to be a great CI" workshop and it was a fantastic day. The day offered wonderful insights from speakers and a great opportunity to network and create relationships to support future clinical research #ClinicalTrials @uofgmvls.bsky.social @uofgshw.bsky.social
- Reposted by Prof Amanda J FarrinFern Harvey’s fab poster presentation of her systematic review on process evaluations for complex intervention trials. Better reporting of context, mechanisms of action and fidelity would enable greater learning about successful interventions #ImpSci #EIE2025 @au-primarycareuol.bsky.social
- Reposted by Prof Amanda J FarrinA cluster randomised crossover design incorporates the principles of both cluster trials (where groups of individuals eg wards, schools etc are randomly assigned) and crossover trials where, in this case, the clusters cross over to different treatment/s for set time periods 2/7
- Reposted by Prof Amanda J FarrinAt #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9 #MethodologyMonday #120
- Reposted by Prof Amanda J Farrin🚀 Exciting News! 🚀 Interested in or leading a clinical trial? Want to be the best Chief Investigator you can be? This updated course is for you! tinyurl.com/HTBAGCI #ClinicalTrials #CITraining @leedsctru.bsky.social @amandafarrin.bsky.social
- Phew: ResearchFish submitted again for another year ✅️
- Reposted by Prof Amanda J FarrinA common issue in trials is how to accommodate multiple important outcomes. Approaches include composite outcomes or using the win ratio method (I have posted on these before). A newer method is the #DOOR (Desirability of Outcome Ranking) approach 1/7 #MethodologyMonday #113
- 📢 Delighted our CHART trial is now OPEN to recruitment Massive effort from our @complexleedsctru.bsky.social trial team, @drandyclegg.bsky.social @vickigphysio.bsky.social & many others to get this complex study ready to go 🎉 🙏 @nihr.bsky.social for funding
- PenARC & @arc-yharc.bsky.social researchers are working in partnership with older people with #heartfailure and #frailty to increase their independence. > Learn more: tinyurl.com/4xt8f7en @nihrarcs.bsky.social @exeter.ac.uk @universityofleeds.bsky.social @livunipress.bsky.social @nihr.bsky.social
- Reposted by Prof Amanda J FarrinCurrently low response rates from CTU Directors (n=5), Programmers/Data Managers (n=0), & QA Managers (n=3) working in clinical trials. We need to know what these groups think the challenges are for greener trials. forms.office.com/e/fkeLD8HbMA Please complete &RT @ukctunetwork.bsky.social
- Do you work on clinical trials? We need your help to understand the challenges to designing & delivering greener trials. Only 30 responses so far but we can all have a say on this topic. Please take 10 minutes to tell us what you think tinyurl.com/GreenTrials Please share across your networks
- Reposted by Prof Amanda J FarrinConsider what to report about your rehabilitation intervention? Here's a newly published TIDieR Rehab checklist bmjopen.bmj.com/content/14/1...
- Follow @freshstart-uk.bsky.social for all updates from our @leedsctru.bsky.social @nihr.bsky.social programme grant. We've just moved over to this platform 🙂
- FReSH START is a research project aiming to develop a therapy intervention for adults who self-harm. We are now running a clinical trial to see if the therapy we developed is effective and if it improves people's quality of life. #introduction #mentalhealthresearch #selfharm #NIHR
- Reposted by Prof Amanda J FarrinAnother link to survey as initial link problematic for some - forms.office.com/e/fkeLD8HbMA
- Reposted by Prof Amanda J FarrinDo you work on clinical trials? We need your help to understand the challenges to designing & delivering greener trials. Only 30 responses so far but we can all have a say on this topic. Please take 10 minutes to tell us what you think tinyurl.com/GreenTrials Please share across your networks
- Reposted by Prof Amanda J FarrinInteresting historical principles of clinical trial conduct … Rule 5 “the medical statistician has to be competent” … sure hope we’ve got that one sorted!
- #OTD 28 Jan 1809 Louis-Dominique-Jules Gavarret b (d 30 Aug 1890) An early proponent of the 'statistical method' in medicine, his 1840 book 'Principes de Statistique Médicale' was among the first to describe statistical principles for rigorous clinical trial conduct. /10 🧵
- Reposted by Prof Amanda J FarrinAn issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8 #MethodologyMonday #109
- Welcome to bluesky @complexleedsctru.bsky.social 🎉 Please do follow our Complex Interventions Division account for our news of our training opportunities, trial progress and results, as well as signposting to relevant resources for Complex Intervention trialists 👇
- There's only 2 days left to sign up for our Masterclass in the Design and Conduct of Complex Intervention Evaluations! Limited spaces are left! Register here - t.co/V6Q7p51feu
- Reposted by Prof Amanda J FarrinWe've frustratingly allowed "real world" to become a deceptive synonym for "observations we happened haphazardly to make". I'd say half the studies that come to me now, the majority of which are useful but modest clinical audits, will have "real world" in the proposal title. It's magic!
- Reposted by Prof Amanda J FarrinI am not that surprised that more women quit academic publishing than men- this chimes with data showing fewer women get their papers published, grants funded if they lead them and that more women get pushed into support roles. We do need to do more to support and mentor female staff. 🧪
- Snow day #Yorkshire #Langsett
- Reposted by Prof Amanda J FarrinWant to know how to report a cluster-crossover trial … the CONSORT extension reporting guidance is out 😊 www.bmj.com/content/388/...
- We're running our annual online Masterclass in Complex Interventions Evaluations over 3 days in January and February. Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social Register now to reserve your place. Deadline 24 Jan. Link below 👇
- Just a wee bit of snow in Yorkshire 🥶❄️
- Reposted by Prof Amanda J Farrin🤢 horrifying piece of work, which we’ll see idiots quoting. For goodness sake @jclinepi.bsky.social
- Happy New Year! May your 2025 be healthy, prosperous, and full of interesting research questions to explore!
- Beautiful light from the late December sun in one of my favourite places today #PeakDistrict #LadyBower to #LostLad and back
- Happy Boxing Day from a very sunny Yorkshire 😎🎄 Perfect temperature inversion around #EmleyMoorMast
- Reposted by Prof Amanda J FarrinWith the approaching the start of the holidays please remember that HOW to ‘switch off’ is your thing. There’s no manual. Whatever suits you. Checking emails is not a crime during this time but it’s good practice -if you email back- to schedule sending for when the holiday is over.
- Beautiful day for graduation 🎓 ceremony. So proud of Dr Sadia Ahmed: our 1st @mrcnihrtmrp.bsky.social PhD student to graduate from @leedsctru.bsky.social Grateful for my co-supervisors @suzrich.bsky.social & Andy Clegg And thank you for the beautiful flowers Sadia: but you did the hard work
- Reposted by Prof Amanda J FarrinI love PhD graduation ceremonies. It is a celebration of watching someone grow in skills and confidence. Congrstulations Dr Sadia Ahmed. @amandafarrin.bsky.social @drandyclegg.bsky.social
- Reposted by Prof Amanda J Farrin-ology = study of methodology = study of method trial methodology = study of the method of clinical trials, including scientific & operational aspects Importantly, a trial methodologist is not necessarily an expert in trial design and analysis
- Reposted by Prof Amanda J FarrinInterest in learning more about Multiphase Optimisation Strategy (MOST) framework & optimisation trials? New CPD course at University of Leeds on this topic, from 22nd to 24th Jan. The early bird registration deadline is 20th Dec. Read more: medicinehealth.leeds.ac.uk/dir-record/r...
- Reposted by Prof Amanda J FarrinQ what should people do in response to the new guidance? 1) be aware of it; 2) read it and consider how you might change what you do; 3) planned/ongoing engagement between WHO and national-level regulators...
- Reposted by Prof Amanda J FarrinVasee Moorthy of WHO talks about the need for proportionate clinical trials training - and not being too led by ICH GCP in all settings/trial types given its origins in the world of drug development
- Reposted by Prof Amanda J FarrinRecording of our CONSULT training launch webinar now added to the website, alongside details about how to access the e-learning: 🔗https://capacityconsentresearch.com/training Many thanks to the panel @kerryhood.bsky.social @amymrussell.bsky.social @markjayes.bsky.social & others! #Inclusivity
- 📢Now live📢 CONSULT e-learning on trials involving adults with impaired capacity to consent - 4 core modules, case studies, links to resources, free to access, download a certificate on completion 🔗https://www.capacityconsentresearch.com/training @kerryhood.bsky.social @ukctunetwork.bsky.social
- Reposted by Prof Amanda J Farrin📢Now live📢 CONSULT e-learning on trials involving adults with impaired capacity to consent - 4 core modules, case studies, links to resources, free to access, download a certificate on completion 🔗https://www.capacityconsentresearch.com/training @kerryhood.bsky.social @ukctunetwork.bsky.social
- Reposted by Prof Amanda J FarrinInnovative trials in stroke showcased by @amandafarrin.bsky.social today at #UKSF24
- Reposted by Prof Amanda J FarrinPromoting hybrid and remote de-centralised elements and outcome selection for platform trials
- Reposted by Prof Amanda J FarrinIf you're interested in how to measure psychological problems after stroke, please consider filling out our quick survey linktr.ee/leeds_ctru?u... @leedsctru.bsky.social
- Reposted by Prof Amanda J FarrinLooking for people to join our stakeholder group to develop a core outcomes set for trials of interventions designed to treat/prevent psychological problems post-stroke! You may have spotted this slide in @amandafarrin.bsky.social's talk at #uksf24 this morning...
- Reposted by Prof Amanda J FarrinProf Amanda Farrin on the future of trial design & need for platform designs; faster, cheaper, sooner evidence available for practice. Challenging design but very much needed across acute and life after stroke #uksf24 @amandafarrin.bsky.social
- Reposted by Prof Amanda J FarrinCome and do a Dunhill Medical Trust #PhD with me and @jufrost.bsky.social looking at #CGA for people with #heartfailure and #frailty as part of the @nihr.bsky.social funded CHART trial and #processevaluation www.exeter.ac.uk/study/fundin...
- And we're off. @lisakidd22.bsky.social welcoming us all to #UKSF24. Looking forward to 2 days of all things stroke-related
- On my way to #UKSF2024 🙂 @bethancopsey.bsky.social & I are hosting a Table in the Research World Cafe at 12 noon. Come and tell us about the opportunities & challenges for #ClinicalTrials & how the @thestrokeassoc.bsky.social research strategy can support more trials in the future #HaveYourSay
- Reposted by Prof Amanda J FarrinFirst up on my #uksf24 agenda for today is co-hosting a table @thestrokeassoc.bsky.social's Research World Cafe session! Come and join us - we'd love to hear your thoughts about recruitment and retention and how the Stroke Association might support it #ukstrokeforum2024 @auasresearch.bsky.social
- Reposted by Prof Amanda J FarrinPLEASE SHARE: Registration is now open for the next Introduction to Causal Inference Course for Health & Social Scientists (7-11 July 2025, Leeds, UK). See more info & register here: www.causal.training Note, we are not planning any other courses until 2027. #CausalIntroCourse #EpiSky #CausalSky
- *Risk-proportionate* trial monitoring: a key element of trial integrity. Helpful 🧵from @marionkcampbell.bsky.social 👇
- A key component of trial conduct is monitoring of the integrity of the data quality and assessment that conduct of trial processes are being accurately followed 1/7 #MethodologyMonday #107
- Reposted by Prof Amanda J FarrinIt feels like a good day to share this "It actually doesn't take much to be considered a difficult woman. That's why there are so many of us." Jane Goodall
- Very much looking forward to speaking in this #UKSF session next week and sharing my thoughts on the methodological future for efficient stroke trials. Just need to squeeze that huge topic into 15 mins and finish off my slides! 😂
- Back home after a long day out at the launch event for the cross NIHR collaboration on #MLTC. Fascinating challenges ahead for the research - and care - communities
- Reposted by Prof Amanda J FarrinI am looking for a PhD student in Medical Statistics. This project aims to develop new methods for design of early phase trials starting from monotherapy and progressing into combinations. More details are in the link. Feel free to contact me if any questions. www.findaphd.com/phds/project...
- Reposted by Prof Amanda J FarrinA methodological review identified several options for utilizing registries for randomized controlled trials - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...
- Hurrah - we get to see @marionkcampbell.bsky.social Methodology Monday posts here 👇 Always a good read and just the right bite-sized chunk of wisdom to peruse with the first coffee of the week ☕
- Many of you know I post something about methods most Mondays on the “other side”… will share here too. Here is today’s … It is often important to assess not only the effectiveness of an interventions in a trial but also the #CostEffectiveness of the intervention 1/7 #MethodologyMonday #106
- Reposted by Prof Amanda J FarrinWondering how to use Bluesky feeds, blocklists, and filters? Are you worried that Bluesky will inevitably turn evil? Are you wondering what the Alf thing is about, but are too afraid to ask? I try to answer your questions here: little-flying-robots.ghost.io/the-great-bl...
- What a difference a day makes 😊🥶 But Edinburgh is beautiful in both sun and snow
- Fantastic keynote from @eleanormitchell.bsky.social to kick off day 2 of Edinburgh Clinical Trial Management Course - sharing her inspirational 20+ year career in trial management
- Reposted by Prof Amanda J Farrin📢Join us📢 at our upcoming webinar introducing the CONSULT e-learning on trials involving adults with impaired capacity to consent - plus an opportunity to ask our expert panel about key challenges you encounter! 📆5th Dec 🕑2-3pm 🔗register tinyurl.com/2s3nmbz7 #InclusiveResearch #Inclusivity
- Reposted by Prof Amanda J FarrinDid you know that by substituting your morning coffee with green tea, you can eliminate up to 93% of what little joy you have left?
- Reposted by Prof Amanda J FarrinToday is equal pay day - the day when women in the UK effectively work for free for the rest of the year, because of the gender pay gap 🙃 To mark the occasion, I've made 'Women of the North' starter pack of the incredible northern women you need to follow... go.bsky.app/P6Hu5Qkat://did:plc:bzttp3fn7i3kleu5rr6sxb5i/app.bsky.graph.starterpack/3lbev2qnhss2l
- Reposted by Prof Amanda J FarrinStarter pack on #PublicInvolvement #PPI #PPIE #Coproduction and #ParticipatoryResearch. Kindly put together by @louca-mai.bsky.social 🌟at://did:plc:d5uwtmffavtsyj7hadsywabg/app.bsky.graph.starterpack/3l6rqanrxz22x
- Reposted by Prof Amanda J FarrinI've only been working with the stroke community for a little over a year - each time, i'm struck by their passion, committment, and incredible dedication to supporting stroke survivors in their recovery. I want to start there because i think it would tell only half the story to talk about... 1/
- Reposted by Prof Amanda J FarrinLoving this paper 'Rethinking barriers and enablers'. How many thousands of weak research studies have reduced complex change to 'identifying and addressing barriers and enablers'? Here's how to do better! journals.sagepub.com/doi/full/10....
- Reposted by Prof Amanda J FarrinDo you have a degree in a health related subject and experience of qualitative research methods?Are you looking for PhD opportunities? Would you like to work on trials methods research? Then this might be the answer.... tinyurl.com/DataIntegr
- I'm new to Blue Sky so it seemed fitting to add today's view as my first post, definitely a blue sky kinda day ❄️🌞 #WorkFromHome
