Danny IncaRNAto
Associate Professor in Molecular Genetics | University of Groningen | Chief R&D Officer @ Serna Bio | #RNA structural ensembles & dynamics | https://www.incaRNAtolab.com | Views are my own
- As it's almost Christmas, here're 2 presents from the lab! 🎄 First: #RNA Framework 2.9.5 is out! Several additions, fixes and improvements. Check it out: lnkd.in/gi3QDNeq & see the CHANGELOG (shorturl.at/Lcobs) for the details! (1/n)
- #RNA Framework 2.9.4 is out! Several additions, fixes, improvements. Check it out: github.com/dincarnato/R... & see the CHANGELOG (buff.ly/4gtJ67u) for the details! (1/n)
- Reposted by Danny IncaRNAto[Not loaded yet]
- So excited to see this out in @natgenet.nature.com! An amazing collaboration with @gagneurlab.bsky.social, I am happy I was (a small) part of. Nucleotide dependencies can capture regulatory elements, including #RNA structures! Congrats to the whole team! Check it out: www.nature.com/articles/s41...
- Looking forward!
- Reposted by Danny IncaRNAtoTwo group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.
- Check out this new fantastic method from @rivaselenarivas.bsky.social to predict #RNA structure + 3D motifs and pseudoknots guided by covariation
- Integrated prediction of RNA secondary structure jointly with 3D motifs and pseudoknots guided by evolutionary information. @aakaran31.bsky.social and @rivaselenarivas.bsky.social link.springer.com/article/10.1...
- Happy #RNA day to all my fellow RNA lovers!
- I am so incredibly excited to share our latest work, on the exploration of #RNA secondary structure ensembles and discovery of RNA regulatory structural switches in bacteria and human cells, just out in @natbiotech.nature.com: nature.com/articles/s41.... A short tread! (1/n)
- By performing ensemble deconvolution analysis of the E. coli transcriptome, we identified a large number of regions populating 2+ alternative conformations, characterized by features such as high G+C content, low Shannon entropy, high structuredness and conservation, etc. (2/n)
- The IncaRNAto lab is seeking a motivated #PhD candidate, interested in studying #RNA structural ensemble dynamics in living cells. Here's the link to the vacancy: www.rug.nl/about-ug/wor.... Please share!
- #RNA Framework 2.9.3 is out! Lots of improvements! Check it out: github.com/dincarnato/R... & see the CHANGELOG (raw.githubusercontent.com/dincarnato/R...) for the details!
- Reposted by Danny IncaRNAtoIn a preprint published today, we are excited to report the secondary structure of the 1212 nt fission-yeast S. pombe telomerase RNA, TER1, and its roles in the physicofunctional organization of this massive, flexible enzymatic RNP complex. www.biorxiv.org/content/10.1...
- Reposted by Danny IncaRNAtoNIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
- Reposted by Danny IncaRNAto[Not loaded yet]
- #RNA rules
- Reposted by Danny IncaRNAtoWe present Rfam-based RNA structural alignments and other structure-based inputs for RNA 3D structure prediction by deep learning. www.biorxiv.org/content/10.1...
- Reposted by Danny IncaRNAto[Not loaded yet]
- #RNA Framework 2.9.2 is out! Several fixes and improvements, particularly for mutlithreading. Check it out: buff.ly/4guLWsP & see the CHANGELOG (buff.ly/4gtJ67u) for the details!
- Amazing new paper from @rivaselenarivas.bsky.social keeps improving #RNA covariation analysis, by adding RNA 3D motif prediction from alignment in R-scape!
- The full #RNA conformational landscape of RNase P in solution: www.nature.com/articles/s41...
- Reposted by Danny IncaRNAto[Not loaded yet]
- Reposted by Danny IncaRNAto[Not loaded yet]
- #RNA Framework 2.9.1 is out! Major NEW feature: RF can now use #R and #ggplot2 to generate several publication-ready plots.. Check it out: buff.ly/4guLWsP & see the CHANGELOG (buff.ly/4gtJ67u) for the details! Below a gallery of the various plots:
- This is huge. Mis-splicing of a 24nt-long micro-exon in the CPEB4 #RNA binding protein leads to formation of irreversible aggregates, which normally would dissolve after depolarization, and consequent deregulation of genes associated with autism spectrum disorders www.nature.com/articles/s41...
- #RNA Puzzles Round V www.nature.com/articles/s41...
- Reposted by Danny IncaRNAto[Not loaded yet]
