did:plc:lucojbzfqhbaeellzvkhdf6w
PhD Student in Integrative structural biology on RNA-binding proteins.
#crystallography #SAXS #NMR #RNA #biophysics #biochemistry #structuralbiology
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- Reposted by did:plc:lucojbzfqhbaeellzvkhdf6w⭐NAR Breakthrough! ⭐ 🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/... #NARBreaktrhough #RNA #StructuralBiology
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- Reposted by did:plc:lucojbzfqhbaeellzvkhdf6wbiorxiv.org/content/10.1... Here’s a paper that was many years in the making. The idea that the climate can affect the thermodynamic mechanism of binding due to the temperature dependence of the entropy term is interesting- we see gradual shift in binding mode along evo trajectory…
- Reposted by did:plc:lucojbzfqhbaeellzvkhdf6wPre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the @corcoranlab.bsky.social with @nogasharlin.bsky.social, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran www.biorxiv.org/content/10.1...
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- Our work on how a conserved core network in the SARS-CoV-2 nucleocapsid NTD affects stability, RNA-binding affinity, and selectivity of the domain is now online. www.nature.com/articles/s41...
