Sarah Rauscher
Associate Professor, Computational biophysicist @UofT
http://rauscher-group.physics.utoronto.ca
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- Reposted by Sarah RauscherWant to learn about how we use computational approaches at different scales to study biomolecular condensates? Check out our latest review, out in Advances in Physics X @juliamaristany.bsky.social @alinaemelianova.bsky.social @rcollepardo.bsky.social www.tandfonline.com/doi/epdf/10....
- Reposted by Sarah RauscherWe’re hiring! The Department of Physics @sfuphysics.bsky.social at Simon Fraser U (in beautiful and vibrant Vancouver) seeks applications for an Assistant or Associate Professor in Experimental Biophysics, encompassing all scales of life from molecules to ecosystems. @sfuscience.bsky.social
- Reposted by Sarah RauscherSo proud of this work in which we managed to extract valuable information from the intra- and interdomain dynamics of the Tau protein, it indeed looks like there is valuable information to find in protein disorder, if one figures out how to retrieve it !
- "Across (Conformational) Space and (Relaxation) Time", @marienj.bsky.social's latest work, is now out in J. Phys. Chem. B @pubs.acs.org. In this paper, we used coarse-grain simulations with the CALVADOS model to investigate the dynamics of a large IDP. pubs.acs.org/doi/10.1021/...
- Reposted by Sarah Rauscher📢 New preprint: Experiment-guided AlphaFold3 resolves accurate protein ensembles. doi.org/10.1101/2025... AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
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- Reposted by Sarah Rauscher📢 New preprint: Aromatic Ring Flips Reveal Reshaping of Protein Dynamics in Crystals and Complexes. We addressed a long-standing question that people debated already in the 1970s - but it still remained open: Do proteins in crystals move as they do in solution? We used ring flips to find out. 1/n
- Reposted by Sarah RauscherWe are thrilled to be part of Project Diffuse, building infrastructure for the dynamic future of structural biology. We are helping to lead the modeling and encoding efforts of this project, including designing infrastructure that allows AI to learn from the full complexity of experimental data.
- What’s the next PDB? Maybe it’s …the PDB. We just launched @diffuseproject.bsky.social a structural biology initiative exploring protein motion & rethinking how we generate and use experimental data. Quick 🧵👇 www.diffuse.science
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- Reposted by Sarah RauscherVery happy that this story found its home at @pnas.org www.pnas.org/doi/10.1073/...
- MD simulations of K+ ions permeation through the MthK potassium channel, done at +150 mV. We developed and applied optimized ion parameters within the Electronic Continuum Correction (ECC) framework. The simulated current quantitatively matches the experimental one. www.biorxiv.org/content/10.1...
- Reposted by Sarah RauscherThe Tortured Proteins Department Esp. 2 with @fraserlab.bsky.social is out! In addition to bantering about the craziness of the times, we chat about some recent exciting preprints (see links below). open.spotify.com/show/10PHVou...
- Reposted by Sarah RauscherA Perspective by @stephanieaw.bsky.social and @fraserlab.com discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery www.nature.com/articles/s41...
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- Looking forward to this workshop on Macromolecular Conformational Ensembles in June!
- Join us for the 2nd Macromolecular Conformational Ensembles Conference on June 9th/10th at UCSF. The most compelling questions in structural biology cannot be effectively addressed using only a single structure. conformationalensembles.github.io @fraserlab.bsky.social
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- Reposted by Sarah RauscherThis is the moment we've worked toward for a long time: First public disclosure of the @asapdiscovery.bsky.social pan-coronavirus antiviral aiming to help keep humanity safe from future pandemic threats like MERS-CoV and other bat coronaviruses.
- 📢Important announcement! Today, the @asapdiscovery.bsky.social consortium disclosed the structure of our preclinical candidate, ASAP-0017445, a promising broad-spectrum antiviral with potent activity against SARS-CoV2 and other viruses belonging to the same family. (1/10)
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- A recent paper, “PEG-mCherry interactions beyond classical macromolecular crowding,” by Liam Haas-Neill from our lab, Khalil Joron and Eitan Lerner @lernerlab.bsky.social is published in Protein Science. onlinelibrary.wiley.com/doi/full/10....
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- Our lab celebrated Ethan Lee's successful PhD defense last week. You can read his recent study on allostery in the main protease of SARS-CoV-2 here: pubs.acs.org/doi/abs/10.1... Stay tuned for more of his work on IDRs + allostery. Congratulations, Ethan!
- Looking forward to #BPS2025 & presenting our collaborative study with @lernerlab.bsky.social on the effects of PEG crowding on the fluorescent protein mCherry. Drop by our poster (Monday, board B4)!
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- Reposted by Sarah RauscherCome be my boss! We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children. Toronto, Canada (the deadline has been extended from Jan 31) Please Re-post. jobs.sciencecareers.org/job/667223/p...
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- Here is a great opportunity for undergraduate students to learn more about research & entrepreneurship in our labs @uoftmississauga.bsky.social this summer --
- We are excited to share our recent simulation study by PhD student Ethan Lee describing the conformational states of the active site loops of the main protease (MPro) of SARS-CoV-2, featured on the cover of Biochemistry: pubs.acs.org/doi/10.1021/...
- Reposted by Sarah RauscherWe're back for 2025! This week we welcome Adam Klosin and Randal Halfmann for the first IDPSeminar of Season 17!
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