Fay Lin
Senior Technology Editor @ GEN
Writing about AI x Bio
✉️ flin@genengnews.com
- Reposted by Fay LinWhat would it take for one AI system to design gene therapies, cell therapies, and antibiotics? @faylinphd.bsky.social explores how EDEN was built to test that idea — using trillions of tokens of evolutionary DNA to learn biology’s underlying rules. Read it here: www.genengnews.com/topics/artif...
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- Altos Labs has taken home the Generalist Prize for the most "well-rounded" model across metrics at @arcinstitute.org's Virtual Cell Challenge! The competition highlights the challenge of defining robust benchmarks for biology. #NeurIPS2025 Read at GEN: www.genengnews.com/topics/artif...
- Reposted by Fay LinAI in Protein Design: Hype vs. Reality Explained by David Baker In this GEN interview, he emphasizes that designing new proteins from scratch is now a reality. Whether AI transforms medicine will require improving our understanding of biology's complexity
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- David Baker's Nobel Prize-winning lab has now designed a molecular on/off switch to control the speed of protein binding, supporting safer medicines that quell harmful side effects and activate drugs on cue, and sensitive biosensors for SARS-CoV-2 testing! www.genengnews.com/topics/artif...
- Genome foundation models, Evo 1 and Evo 2, have now generated viable bacteriophage genomes, demonstrating experimental validation of whole genomes designed by AI! @arcinstitute.org @brianhie.bsky.social @samuelhking.bsky.social Read more at GEN: www.genengnews.com/topics/artif...
- BindCraft is now published in @nature.com! The open-source pipeline for de novo protein binder design achieves significantly improved success rates with nanomolar affinity and therapeutic potential from gene editing to allergens. Read more at GEN: www.genengnews.com/topics/artif...
- OpenCRISPR-1, Profluent's AI-designed gene editor, is now published in Nature! @thisismadani.bsky.social emphasizes the need to move away from random discovery and into bespoke design using AI. 1/ Read more at GEN: www.genengnews.com/topics/artif...
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- David Baker's Nobel Prize-winning lab has now designed binders to "undruggable" disordered proteins, unlocking therapeutic access to over 50% of the human proteome! @uwproteindesign.bsky.social Read more at GEN: tinyurl.com/4fw6wvkm
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- @arcinstitute.org has announced the inaugural “Virtual Cell Challenge,” sponsored by NVIDIA, @10xgenomics.bsky.social and Ultima Genomics, which will evaluate the ability of AI models to generalize to new cell contexts for therapeutic applications. 1/ www.genengnews.com/topics/artif...
- Xaira Therapeutics has released the largest publicly available Perturb-seq dataset to train the AI-powered virtual cell for drug discovery! The work is described in Xaira's first preprint, capping a year after the company's $1 billion launch. www.genengnews.com/topics/artif...
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- Boltz-2 now predicts molecular binding affinity at newfound speed and accuracy - and it's open source! The permissive MIT license allows commercial drug developers to apply proprietary data and offers an advance over the structure prediction capabilities of AlphaFold 3. tinyurl.com/37c96c6y
- AI hype or reality - can we design antibodies from scratch (de novo)? In my latest for GEN, I unpack where de novo design is today and how arguments over terminology have clouded the industry’s shared mission of bringing better therapeutics to the clinic faster. tinyurl.com/4uamc8c5
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- BREAKING NEWS: World’s first patient treated with personalized CRISPR therapy! Born with a severe metabolic disease with a 50% mortality rate, an infant has improved after receiving an individualized gene editing therapy, a glimpse of a new era in genomic precision medicine. tinyurl.com/m52udxht
- Introducing TranscriptFormer, the cross-species cell atlas! This new generative #AI model from @chanzuckerberg.bsky.social is trained on data from over 110 million cells from 12 different species, covering 1.5 billion years of evolution. tinyurl.com/2yet8k42
- Reposted by Fay LinThanks to @faylinphd.bsky.social from @GEN for featuring our manuscript! www.genengnews.com/topics/genom...
- New from @arcinstitute.org is "the largest publicly available #AI model for biology to date"! Evo 2 now includes information from all domains in life to expand its capabilities in generative functional genomics. @pdhsu.bsky.social @brianhie.bsky.social tinyurl.com/3t83vseh
- Leveraging protein structure prediction tools, researchers from Northwestern University present an #AI based framework to uncover potential structural design rules across receptor families for improved cell therapies. Read more at GEN: www.genengnews.com/topics/artif...
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