Leiden Early Drug Discovery & Development (LED3)
LED3 is a hub of scientists working on early drug discovery at the Leiden Institute of Chemistry, the Leiden Academic Centre for Drug Research, the Institute of Biology Leiden and the Leiden Institute of Advanced Computer Science. @LED3hub@mstdn.science
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- We are looking forward to the LED3 Lecture of Christina Woo (@thewoolab.bsky.social) on February 26th. She will talk about "Rewriting Protein Modifications". If you are interested, make sure to come by! www.universiteitleiden.nl/en/science/l... #ChemBio #ChemSky #ChemicalProteomics #TPD
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- We are very happy that @anneosbourn.bsky.social from the @johninnescentre.bsky.social visited us today for a LED3 Lecture. She talked about "Harnessing plant metabolic diversity for food and health applications". #Plants #NaturalProducts #GeneClusters #DrugDiscovery #ChemBio #ChemSky #Food #Health
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- Are you interested in cutting-edge research in Early Drug Discovery and Development? We have a great program for our LED3 Lectures for the remaining academic year. Check out the program and mark your calendars! www.universiteitleiden.nl/en/science/l... #DrugDiscovery #ChemSky #ChemBio
- We are looking forward to the LED3 Lecture of Anne Osbourn on January 29th She will talk about "Harnessing plant metabolic diversity for food and health applications". If you are interested, make sure to come by! www.universiteitleiden.nl/en/science/l... #ChemBio #ChemSky #Plants #Metabolites
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- Another exciting year for our LED3 hub comes to a close. We were able to celebrate many successes including grants, publications, awards and started companies. In 2025, the activities of LED3 were also formalized in the theme "Drug Discovery and Development" of @leidenscience.bsky.social. (1/3)
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- Congratulations to the LED3 members that received NWO XS grants: @mads-chem.bsky.social - Inhibiting the growth of brain tumours Margo Dona - Rapid personalised treatment for anaplastic thyroid cancer Sandra Irmisch - Producing rare substances for medicines www.universiteitleiden.nl/en/news/2025...
- New Publication from our LED3 hub! The group of @sebastianpomplun.bsky.social published "ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors" in the journal Chem. www.sciencedirect.com/science/arti... #ChemSky #ChemBio #DrugDiscovery #MYC #Cancer
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- It is great to see, how highly represented LED3 researchers are at the #iCNS meeting of the Institute for Chemical Neuroscience. Exciting that our researchers are making so many important contributions to this innovative research direction. (1/4) #ChemSky #ChemBio #Neuroscience #DrugDiscovery
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- Exciting to see the study on the prediction of high-affinity #peptide binders to proteins-of-interests by the group of @sebastianpomplun.bsky.social of our LED3hub highlighted by @dereklowe.bsky.social in his @science.org blog. www.science.org/content/blog... #ChemSky #ChemBio #DrugDiscovery
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- We are very happy that Lotte Bjerre Knudsen from @novo-nordisk.bsky.social visited us today for a very well-attended LED3 Lecture. She talked about the development of GLP-1 agonists into blockbuster medications for the treatment of #diabetes and #obesity. #DrugDiscovery #Peptides #ChemBio #ChemSky
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- Reposted by Leiden Early Drug Discovery & Development (LED3)Great to see our Nature Chemistry paper out in its final published and printed form. If you want to check it out, you can find it here: www.nature.com/articles/s41... #ChemSky #ChemBio #ChemicalProteomics #Chemoproteomics #ProteoProbes #ChemPro
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- We are looking forward to the LED3 Lecture of Lotte Bjerre Knudsen from Novo Nordisk on November 27th: "GLP-1 receptor agonists: State of the art and the newest insights" If you are interested, make sure to come by! www.universiteitleiden.nl/en/science/l... #ChemBio #ChemSky #DrugDiscovery
- Are you excited about DNA-encoded libraries? According to this new study by the @sebastianpomplun.bsky.social group of our LED3 hub, you may even get away without needing the DNA barcode. They describe self-encoded libraries (SELs) for #DrugDiscovery. www.nature.com/articles/s41... #ChemSky #ChemBio
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- Looking for a high-affinity #peptide binder for your favorite target? According to the newest paper by the group of @sebastianpomplun.bsky.social, the software tool #BindCraft allows you to predict such binders with high success rates. pubs.acs.org/doi/10.1021/... #ChemSky #ChemBio #DrugDiscovery
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- Interesting Tuesday Talk at @leidenscience.bsky.social by Ilze Bot of our LED3 hub. Under the title "Breaking the cycle of heart attacks", she talked about her research into, why heart attacks are still a big threat, even in patients receiving treatment. #ChemSky #ChemBio #DrugDiscovery
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- Jeroen Codee speaks at the #Reedijk Symposium: "A new twist in the tale - stereoselective glycosylation reactions for bacterial glycan assembly". Exciting insights into the importance of advanced glycosylation chemistries to make complex glycosides to better understand (bacterial) biology.
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- Huge congratulations to @craigmcrews.bsky.social on being awarded the #Havinga medal at the #Reedijk Symposium of the Leiden Institute of Chemistry for his groundbreaking work on induced proximity, including targeted protein degradation, as a new paradigm for #DrugDiscovery. #ChemSky #ChemBio #TPD
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- Kim Bonger (@kimmb1.bsky.social) represents our @led3hub.bsky.social at the #Reedijk Symposium of the Leiden Institute of Chemistry with a great talk on "Chemical tools for profiling protein activity and cell targeting in (auto)immune disease". #ChemBio #ChemSky #DrugDiscovery #FluorescenceFriday
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- We are very happy that Nicolas Winssinger visited us today for a LED3 Lecture. He talked about his group's research into using functional nucleic acid assemblies for various applications including highly selective protein inhibitors and targeted photodynamic therapy. www.nature.com/articles/s41...
- How can the selectivity of covalent inhibitors be studied at diverse amino acids? In their Nature Chemistry paper the group of @stephanhacker2.bsky.social of our LED3hub developed an unbiased workflow to study electrophile reactivity and selectivity proteome-wide.(1/2) www.nature.com/articles/s41...
- Reposted by Leiden Early Drug Discovery & Development (LED3)How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid? Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7) www.nature.com/articles/s41...
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- We are looking forward to the LED3 Lecture of Nicolas Winssinger on Thursday October 30th: "Programing responsive assemblies from PNA-encoded and folded peptides" If you are interested, make sure to come by! www.universiteitleiden.nl/en/science/l... #ChemBio #Chemistry #DrugDiscovery
- We are looking forward to the LED3 Lecture of Nicolas Winssinger on Thursday October 30th: "Programing responsive assemblies from PNA-encoded and folded peptides" If you are interested, make sure to come by! www.universiteitleiden.nl/en/science/l... #ChemBio #ChemSky #DrugDiscovery
- What will future last resort #antibiotics look like? How can we make them safer to use? In their project PRADA, the group of Nathaniel Martin is setting out to answer these questions. Check out the linked video to learn more. www.linkedin.com/posts/biotec... #ChemSky #DrugDiscovery #Antibiotics
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- On November 11th, Ilze Bot will present her exciting research in our LED3hub at the @leidenscience.bsky.social Tuesday Talks to the Faculty. She will talk about "Breaking the Cycle of Heart Attacks". If you are interested, make sure to register: www.universiteitleiden.nl/en/events/20...
- Are you interested in #StructuralBiology? Register for the Kroese-Duijsters Symposium 2025 organized by our LED3 colleagues @steffenbruenle.bsky.social and Sebastian Geibel. A great lineup of speakers including keynotes Ulrich Lorenz and Jörg Standfuss. www.universiteitleiden.nl/en/kroese-du...
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- Great talk by Kim Bonger (@kimmb1.bsky.social) at our Faculty's (@leidenscience.bsky.social) Tuesday Talks. She talked about her group's exciting research into precision medicine with a special focus on autoimmune diseases. #ChemBio #ChemSky #DrugDiscovery
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- Hoe zou #antibioticaonderzoek er in de toekomst uit kunnen zien? Hoe kan de ontwikkeling van #antibiotica economisch aantrekkelijker worden gemaakt? Als u geïnteresseerd bent in deze vragen, lees dan het interview met @gillesvanwezel.bsky.social www.sciencelink.net/verdieping/p... #Chemie #ChemBio
- How could #antibiotic research look like in the future? How can antibiotic development be made more economically rewarding? Check out the interview with LED3 hub researcher @gillesvanwezel.bsky.social (Dutch only). www.sciencelink.net/verdieping/p... #ChemSky #ChemBio #DrugDiscovery
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- We are very happy that Tudor Oprea from Expert Systems Inc. visited us today for a talk. He talked about the use of Machine Learning and Artificial Intelligence in Drug Discovery.
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- We are very much looking forward to the LED3 Lecture by Nicolas Winssinger on Thursday, October 30th, at 4 p.m. He will talk about his research into "Programing responsive assemblies from PNA-encoded and folded peptides" www.universiteitleiden.nl/en/science/l... #ChemSky #ChemBio #DrugDiscovery
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- We are very happy that Alex Bullock from the University of Oxford (@ox.ac.uk) visited us today for a very well attended lecture. He talked about his group's work on making new E3 ligases available for degrader development using PROTACs and molecular glues. www.nature.com/articles/s41...
- We were very excited that Willem Velema visited us today for a great LED3hub Lecture. He talked about his group's diverse research projects on better understanding the structure of RNA motives and their ligandability with small molecules using techniques such as affinity-based profiling.
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- Do not miss this week's LED3 Lecture by Willem Velema! www.universiteitleiden.nl/en/science/l...
- On October 14th, Kim Bonger (@kimmb1.bsky.social) will present her exciting research in our LED3hub at the @leidenscience.bsky.social Tuesday Talks to the Faculty. If you are interested, make sure to register: www.universiteitleiden.nl/en/events/20...
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