Quaid Morris
Computational biology, machine learning, AI, RNA, cancer genomics. My views are my own. https://www.morrislab.ai
He/him/his
- Reposted by Quaid MorrisAlphaGenome is out in @nature.com today along with model weights! 🧬 📄 Paper: www.nature.com/articles/s41... 💻 Weights: github.com/google-deepm... Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc
- Now with a bioinformatics/genomics label 🖥️🧬
- In a new paper, we introduce Metient, a new method to reconstruct the migration history of metastatic clones, and learn cancer-type specific patterns of metastatic spread, from bulk or single-cell sequencing data. www.nature.com/articles/s41...
- In a new paper, we introduce Metient, a new method to reconstruct the migration history of metastatic clones, and learn cancer-type specific patterns of metastatic spread, from bulk or single-cell sequencing data. www.nature.com/articles/s41...
- Metient can help answer key questions about metastatic spread: How often do metastases seed other metastases? How often do multiple clones seed a single metastasis? Is metastatic potential rare, or gained multiple times by the same cancer?
- Reposted by Quaid MorrisJoin @stirlingchurchman.bsky.social, @moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
- Reposted by Quaid MorrisSAVE THE DATE: the yearly NY Population Genetics meeting will be back on March 9 2026, generously hosted by the @simonsfoundation.org. Details to follow. Please RT.
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- Reposted by Quaid MorrisNew Reactome paper in NAR 2026 Databases Issue: doi.org/10.1093/nar/... Redesigned Angular interface ReacFoam & entity-level visualizations Multi-omics analysis tools React-to-Me chatbot FAIR-compliant, CoreTrustSeal certified, and ELIXIR-recognized 🖥️🧬
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- Reposted by Quaid MorrisIt's always exciting when the latest edition of JASPAR comes out. Great leadership by @amathelier.bsky.social and pleased to welcome @anshulkundaje.bsky.social to the journey. #Jaspar2026 academic.oup.com/nar/advance-...
- Reposted by Quaid MorrisFifteen Years xkcd.com/3172/
- Reposted by Quaid MorrisWe are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
- Reposted by Quaid MorrisMessenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export? Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)
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- Reposted by Quaid Morrisnew Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4 rdcu.be/eOc0q
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- Reposted by Quaid MorrisFantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...
- Reposted by Quaid MorrisMy institution---the Sloan Kettering Institute, the basic science arm of the Memorial Sloan Kettering Cancer Center---is hiring new faculty this cycle! Applications close Nov 15. www.mskcc.org/research/ski...
- Reposted by Quaid MorrisThe most important paper in evolutionary biology I'd never heard of: 1/ www.sciencedirect.com/science/arti...
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- Reposted by Quaid MorrisI'm very pleased to announce the official publication of our lab's paper "DNA mutagenesis driven by transcription factor competition with mismatch repair" in today's issue of Cell! www.cell.com/cell/abstrac...
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- Reposted by Quaid Morriswww.biorxiv.org/content/10.1... Delighted to share the story of two germline RBPs - one with little (DND1) and one with no (NANOS3) intrinsic sequence-specificity - that together build a continuous RNA binding surface recognizing a 7-mer (AUGAAUU) in target mRNA 3’UTRs, leading to deadenylation.
- Reposted by Quaid MorrisThis is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...
- Reposted by Quaid MorrisHi @npr.org! We worked late tonight putting together this handy pocket guide! It doesn't address road design issues, but if we're going to educate road users, we should include drivers. It's the size of a folded business card. Print it, fold it, put it in your wallet!
- Reposted by Quaid Morrishey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!
- Reposted by Quaid MorrisA huge shoutout to all the dedicated grants management specialists at the NIH who are working around the clock to push grants out before the Sep 30 deadline. And also to the POs responding to frantic emails. Not an easy job under the best of circumstances and right now it's the pits. Thank you!
- Reposted by Quaid MorrisYouTube link for MLCB2025 is up! Starting in 30 min. www.youtube.com/live/19I7xTh...
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- FYI, if your code is written in MATLAB, your 2025 manuscript will not be read by me
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If you like transcription regulation and its mechanisms, this WIP list is for you. I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list. go.bsky.app/8vTgeXBat://did:plc:y655pqb5a3etnlz62iqgck5d/app.bsky.graph.starterpack/3lxhl3qh3ay2d - Reposted by Quaid MorrisRNA is far more than a messenger. Its structures regulate, evolve, and catalyze — carrying out functions DNA alone cannot. But predicting #RNA structure from sequence is still extremely difficult. In our recently published paper in @narjournal.bsky.social we present a way forward. 🧵 ⤵️
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- Reposted by Quaid MorrisTo all post-docs: The Genome Biology dept @embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
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- Please welcome @nickymcgranahan.bsky.social to Bluesky! I'm excited that he is here
- Reposted by Quaid MorrisWe are excited to introduce mRNABench, a comprehensive benchmarking suite that we used to evaluate the representational capabilities of 18 families of nucleotide foundation models on mature mRNA specific tasks. Paper: doi.org/10.1101/2025... Code: github.com/morrislab/mR... A 🧵
- Reposted by Quaid MorrisWe're excited to release 𝐦𝐑𝐍𝐀𝐁𝐞𝐧𝐜𝐡, a new benchmark suite for mRNA biology containing 10 diverse datasets with 59 prediction tasks, evaluating 18 foundation model families. Paper: biorxiv.org/content/10.1... GitHub: github.com/morrislab/mR... Blog: blank.bio/post/mrnabench
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- Reposted by Quaid MorrisNew paper: More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. www.biorxiv.org/content/10.1...
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- Please check out our new approach to modeling somatic mutation signatures. DAMUTA has independent Damage and Misrepair signatures whose activities are more interpretable and more predictive of DNA repair defects, than COSMIC SBS signatures 🧬🖥️🧪 www.biorxiv.org/content/10.1...
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- Reposted by Quaid MorrisJust a nice reminder! 🧪🧬🖥️ I found this GitHub very useful: github.com/cxli233/Frie...
- Reposted by Quaid MorrisFree in-person registration is open for #MLCB2025! Sept 10-11 at @nygenome.org and online at youtube.com/@mlcbconf. Paper/abstract deadline is June 1, more deets including our fantastic invited speaker lineup at mlcb.org! Please RP.
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- RIP Sayan www.mis.mpg.de/news/loss-sa...
- Reposted by Quaid MorrisThis is the moment we've worked toward for a long time: First public disclosure of the @asapdiscovery.bsky.social pan-coronavirus antiviral aiming to help keep humanity safe from future pandemic threats like MERS-CoV and other bat coronaviruses.
- 📢Important announcement! Today, the @asapdiscovery.bsky.social consortium disclosed the structure of our preclinical candidate, ASAP-0017445, a promising broad-spectrum antiviral with potent activity against SARS-CoV2 and other viruses belonging to the same family. (1/10)
- Reposted by Quaid MorrisInterested in doing a sabbatical at EMBL, at one of its 6 sites in Barcelona, Cambridge, Grenoble, Hamburg, Heidelberg or Rome? Funding call with deadline 15 June, decisions in July. www.embl.org/about/info/s...
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- Errands for RNA!
- RNA xkcd.com/3056
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