Debraj Ghose
I study how lymphocytes self-organize into multicellular structures. Also interested in how cells sense and respond to chemical gradients. Currently: Wyss Institute at Harvard. Previously: Comp Bio at Duke. debrajghose.com
- Reposted by Debraj GhoseThrilled that the lab's first @hhmijanelia.bsky.social project is up on bioRxiv! Story behind the story to follow. www.biorxiv.org/content/10.6...
- Reposted by Debraj GhoseSit with this for a moment.
- ASCB President Mary Munson awards Francis Collins the ASCB Public Service award, noting this is the first time it’s been awarded for defense of science #cellbio2025
- Reposted by Debraj GhoseI just published: ERC-Plus: jackpot science or missed chance to fix academia? My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building. medium.com/p/erc-plus-j...
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- Reposted by Debraj GhoseAn exciting PhD opportunity is available in my lab! More info about our group and research can be found here: bdaum2.wixsite.com/daumlab Application deadline: 8th Jan 2026. Apply here: www.exeter.ac.uk/study/pg-res... If you are interested, get in touch! #ArchaeaSky #CryoEM #TeamTomo
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- 1/5: New preprint: Cytokines control the physical state of immune tissue. www.biorxiv.org/content/10.1... Unlike structured organs (heart, liver), immune tissue can shapeshift to form functional structures like germinal centers (GCs), tertiary lymphoid organs, granulomas, etc.
- Reposted by Debraj GhoseHow can cells self-organize rapidly into complex patterns during development? Let’s explore a powerful and underappreciated mechanism: Directed Cell Migration (DCM). Preprint @biorxivpreprint.bsky.social : doi.org/10.1101/2025... 👇Thread 🧵(1/11)
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- Reposted by Debraj GhoseFINALLY out in #Science Advances! 🎉 3 years of hard work, a fantastic team — and I’m proud to be first and co-corresponding author! It's about Plexin signaling driving collective cell migration & organ sculpting. Check out the videos 😀 www.science.org/doi/10.1126/... #DevBio #CellBio #Microscopy
- 3D printed microscopy we could perhaps try in the lab onlinelibrary.wiley.com/doi/10.1111/...
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- Reposted by Debraj GhoseWhat governs where DNA replication begins in human cells? Here, we show that origins of replication in human DNA are epigenetically specified and that crucially, this epigenetic mark is required for both DNA replication and cell proliferation! @narjournal.bsky.social academic.oup.com/nar/article/...
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- We found that cells use emergent collective memory—arising from simple chemical reactions—to outperform physical limits of detecting chemical gradients. Curious how? 1/n 8 min talk: www.youtube.com/watch?v=A7XH... bioRxiv: www.biorxiv.org/content/10.1... #biophysics #cellbiology
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- Self-regulating insulin, very cool! www.nature.com/articles/s41...
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- Reposted by Debraj Ghose"Ants solving a geometric problem and it's amazing." This is a great example of 'emergent phenomenon': - None of the ants understand the problem they're solving. - None of them can see the whole shape. - A series of small decisions or rules add up to something with a new layer of complexity.
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- @itaiyanai.bsky.social I completely agree! However, I've noticed people sometimes misinterpret the advice to avoid rigid hypotheses and assume they don't need to have questions while generating or analyzing data
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