Ana Coelho Almeida
Postoctoring in🇨🇭@ivanagasic.bsky.social Lab
Cell biologist #Cytoskeleton & #Microscopy enthusiast 🔬🧫
- Heading to #CellBio2025 @ascbiology.bsky.social @embo.org? Stop by my poster P0101 tomorrow (Sun, 12:45 PM) in the session “Cytoskeleton and Motility-Microtubule Organization and Dynamics”. Looking forward to lively discussions on tubulin regulation & microtubule organization. See you in Philly!
- Reposted by Ana Coelho AlmeidaAnd now… part two of our twin papers on how chromosomes find their place before division! Led by @krunovuk.bsky.social at @institutrb.bsky.social, out in @natcomms.nature.com! doi.org/10.1038/s414... doi.org/10.1038/s414... Missed the thread on the first paper? Catch up: bsky.app/profile/ivat...
- Reposted by Ana Coelho AlmeidaHuge congratulations to Wieczorek Lab PhD student Bin Cai and now-PI Jingwei Xu @xujwet.bsky.social on figuring out the surprisingly complex structure of the A-C linker crosslinking microtubule triplets in Tetrahymena basal body centrioles! www.science.org/doi/10.1126/...
- Reposted by Ana Coelho Almeida🚨 New preprint out! “Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies. www.biorxiv.org/content/10.1...
- Can’t wait for the BioMatter Meeting in beautiful Arolla 🇨🇭⛰️ Amazing lineup of speakers + cutting-edge science on cytoskeleton dynamics from cells to tissues. See you there!
- 🔎New preprint! We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture. Big thanks to @ivanagasic.bsky.social and team! Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5) www.biorxiv.org/content/10.1...
- (2/5) Loss or mutation of TTC5, the key mediator of tubulin autoregulation, increases tubulin mRNA and protein levels in 3D spheroids. This leads to microtubule hyperstability and reorganization of the network. 📌Tubulin levels matter (even in steady state!)
- (3/5) Tubulin autoregulation is essential for spheroid architecture & viability. Without it: - cells detach (corona forms) - cell death increases 📌This phenotype isn’t due to cell cycle defects or migration — it reflects impaired cell adhesion.
-
View full thread(5/5) Impaired adhesion is driven by changes in tubulin levels and microtubule stability. Reducing tubulin (T007-1) or mild destabilization (nocodazole) rescues the phenotype, while hyperstabilization (taxol) worsens it. 📌Tubulin homeostasis supports multicellular organization.
- EMBO Fellows Meeting 2025 just wrapped up! 4 intense days, 110+ talks, amazing postdocs, mentoring & networking! Huge thanks to @embo.org & the organizers 👏 Feeling proud to be part of the next gen of scientists ready to push science forward. Sharing a few highlights 📸
- Reposted by Ana Coelho Almeida📢We are live everyone ! ! ! We are happy to announce that our official WEBSITE is now online - and early bird registration is OPEN 🎉 👀👇Come check it out🚀🌟 spaom2025.org 🚩Braga, Portugal 📅November 5-7, 2025 #microscopy #science #bioimaging #advancedmicroscopy #spatialbiology #photonics
- Last call for abstracts! 👇 #postdocday
- 🚨 Last week to submit abstracts for talks & posters! Show your research, win prizes & enjoy surprises 🎉 Register here: ‘’ shorturl.at/eOmJt ‘’
