Ying Cao
Cancer is a systemic disease. Understanding a systemic disease needs systemic rules: Tumorigenesis is a process of progressive loss of original cell identity and gain of neural stemness, the general stemness that determines tumorigenicity and pluripotency.
- Exactly. Fundamental biology unveils the top secret of cancer. Understanding cancer &even the inverse correlation between cancer and Alzheimer's disease...... by understanding neural stemness as the core property of cancer cell&rules behind preprints.org/manuscript/2... @crukcamcentre.bsky.social
- Understanding cancer cell &cancer complexity &cancer therapy &even inverse correlation between cancer and Alzheimer's disease... as a whole by Understanding Neural Stemness as the Core Property of Cancer Cell &the rules dictated by neural stemness www.preprints.org/manuscript/2...
- Interpreting cancer cell&cancer complexity&cancer therapy&even inverse correlation between cancer and Alzheimer's disease as a whole ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2... @cp-cell.bsky.social
- Interesting to learn that tumors are outlaw organs. If so, what outlaw organ is liver cancer? It's outlaw liver or outlaw breast or both? What outlaw organ are teratocarcinomas? or what outlaw organ are extraskeletal osteocarcinomas? @cp-cell.bsky.social
- Those who believe EMT/P can help understand cancer or other things should first figure out what the hell is the so-called EMT/P&how it can help. 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' @cp-cell.bsky.social link.springer.com/article/10.1...
- ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2... @cellpress.bsky.social
- In this @cp-cell.bsky.social review, Doug Hanahan shows how the Hallmarks of cancer framework has evolved over the last 25 years: dlvr.it/TQkrlH We'll discuss this in depth @CellSymposia #CSHallmarks2026 dlvr.it/TQkrlK
- True or false? Think a little bit. Critical for understanding cancer/cancer complexity.
- Should those 'scientific discoveries' or 'concepts' that are unfounded or lack basic logic but have been studied for a long time and extensively also be treated in this way? @nature.com 'Lack of basic rationale in EMT and its related concepts' link.springer.com/article/10.1...
- Understanding cancer cell &cancer complexity &cancer therapy &even the inverse correlation between cancer and Alzheimer's disease......... by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. www.preprints.org/manuscript/2...
- Q: which is the softest cell? A: neural cell ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2... @science.org
- 'softening' of cancer cells ...may help the cells to evade antitumor immune defenses. www.science.org/doi/10.1126/...
- 'softening' of cancer cells ...may help the cells to evade antitumor immune defenses. www.science.org/doi/10.1126/...
- Those who believe that EMT is helpful for understanding cancer&other things should first figure out what the hell is the so-called EMT&how it can be helpful. 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts' cellandbioscience.biomedcentral.com/articles/10....
- The original study @cp-cancercell.bsky.social revealed 'the high-plasticity cell state' undergoes 'epithelial-mesenchymal transition' sciencedirect.com/science/arti... &recent study @nature.com showed 'Critical role for a high-plasticity cell state in lung cancer' nature.com/articles/s41...
- The original study @cp-cancercell.bsky.social revealed 'the high-plasticity cell state' undergoes 'epithelial-mesenchymal transition' sciencedirect.com/science/arti... &recent study @nature.com showed 'Critical role for a high-plasticity cell state in lung cancer' nature.com/articles/s41...
- To be simple: Cancer (tumorigenic) cells are almost neural stem/progenitor cells Tumors are almost conjoined twin-like structures (the most obvious example: teratocarcinoma) @cellpress.bsky.social @sciencebriefing.bsky.social
- Understanding cancer cell &cancer complexity &cancer therapy& even the inverse correlation between cancer and Alzheimer's disease......... by understanding neural stemness as the core property of cancer cell &the rules dictated by neural stemness. @cellpress.bsky.social @sciencebriefing.bsky.social
- Cancer is complex. Many theories/hypothesis proposed to explain cancer. Their effectiveness depends on whether it explains cancer complexity as a whole but not just particular details. Any evidence supporting tumors as outlaw organs? @cellpress.bsky.social @sciencebriefing.bsky.social
- Neural stuff is the most fundamental stuff and controls almost everything in the animal kingdom, including embryonic development, regeneration.... and of course, tumorigenesis.
- Unification of cancer cell phenotypic traits by neural stemness @cellpress.bsky.social @sciencebriefing.bsky.social
- Cancer is a complex derivative from normal animals How possible to understand cancer only within the context of cancer but without knowing the basic rules? @cellpress.bsky.social @sciencebriefing.bsky.social ‘.Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2...
- Interesting to learn tumors are organ-like (outlaw organs) If so, does liver cancer look like outlaw liver or outlaw breast or both? What outlaw organ the teratocarcinomas look like? or what outlaw organ the extraskeletal osteosarcomas look like?🤣 @cellpress.bsky.social @sciencebriefing.bsky.social
- Deeply regrettable to see that some of the most fundamental studies in the past have been completely forgotten, failing to provide any inspiration for understanding cancer cell and cancer complexity, eg., pluripotency of cancer cell. @cellpress.bsky.social @sciencebriefing.bsky.social
- Those who believe EMT can help understand cancer or other things should first figure out what the hell is the so-called EMT &how it can be a little bit helpful. 'Lack of basic rationale in epithelial-mesenchymal transition and its related concepts’ cellandbioscience.biomedcentral.com/articles/10....
- The original study @cp-cancercell.bsky.social revealed 'the high-plasticity cell state' undergoes 'epithelial-mesenchymal transition' www.cell.com/cancer-cell/... &recent study @nature.com showed 'Critical role for a high-plasticity cell state in lung cancer' nature.com/articles/s41...
- The original study @cp-cancercell.bsky.social revealed 'the high-plasticity cell state' undergoes 'epithelial-mesenchymal transition' www.cell.com/cancer-cell/... &recent study @nature.com showed 'Critical role for a high-plasticity cell state in lung cancer' nature.com/articles/s41...
- Neural stuff is the most fundamental stuff and controls almost everything in the animal kingdom, including embryonic development, regeneration.... and of course, tumorigenesis. @cp-cell.bsky.social
- Cancer is a complex derivative from normal animals How is it possible to understand cancer only within the context of cancer but without understanding the basic rules in the animal kingdom? @cp-cell.bsky.social ‘.Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2...
- Unification of cancer cell phenotypic traits by neural stemness and understanding cancer complexity by understanding neural stemness as the core property of cancer cell. @cp-cell.bsky.social
- But cancer is much smarter. Understanding cancer by knowing basic rules in the animal kingdom. 'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell' preprints.org/manuscript/2...
- 'FUCK CANCER'🤣 "Sexual abstinence promotes tumor progression by inducing pregnenolone production" sciencedirect.com/science/arti...
- 'FUCK CANCER'🤣 "Sexual abstinence promotes tumor progression by inducing pregnenolone production" sciencedirect.com/science/arti...
- 'Critical role for a high-plasticity cell state in lung cancer' @nature.com www.nature.com/articles/s41...
- ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ preprints.org/manuscript/2... @pnas.org
- As generalized before, most cancer promoting genes are enriched in embryonic neural/neural stemness cells, incl. KRAS/HER2/EGFR/STAT3. They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells. @pnas.org www.pnas.org/doi/10.1073/...
- Inhibition of multiple components in the same regulatory network, ie, the network of the core property of cancer cell, neural stemness, would achieve better effect than inhibition of a single one of course. @pnas.org
- As generalized before, most cancer promoting genes are enriched in embryonic neural/neural stemness cells, incl. KRAS/HER2/EGFR/STAT3. They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells. @pnas.org www.pnas.org/doi/10.1073/...
- As generalized before, most cancer promoting genes are enriched in embryonic neural/neural stemness cells, incl. KRAS/HER2/EGFR/STAT3. They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells. @pnas.org www.pnas.org/doi/10.1073/...
- Understanding the negative correlation between cancer and neurodegeneration by understanding what is the core property of cancer cell. 'Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell' preprints.org/manuscript/2... @nature.com
- For decades, researchers have noted that cancer and Alzheimer’s disease are rarely found in the same person go.nature.com/4jVsd8N
- 🤔🤫🫣
- What does the 'high-plasticity cell state' actually mean? www.nature.com/articles/s41...
- What does the 'high-plasticity cell state' actually mean? www.nature.com/articles/s41...
- ‘Understanding Cancer as a Systemic Disease by Understanding Neural Stemness as the Core Property of Cancer Cell’ www.preprints.org/manuscript/2...
- Recent studies showed GOF mutation in MSI2 @science.org &increased SOX4 activity @cellpress.bsky.social are cancer drivers If notice MSI2&SOX4 are embryonic neural factors instead of two lifeless symbols, cancer might be better understood www.science.org/doi/10.1126/... www.cell.com/cell/fulltex...
- Recent studies showed GOF mutation in MSI2 @science.org &increased SOX4 activity @cellpress.bsky.social are cancer drivers If notice MSI2&SOX4 are embryonic neural factors instead of two lifeless symbols, cancer might be better understood www.science.org/doi/10.1126/... www.cell.com/cell/fulltex...
- What does 'a high-plasticity cell state' mean? @nature.com
- The rule: ∵Tumorigenesis is a process of loss of original cell identity&gain of neural stemness, the general stemness determining tumorigenity&pluripotency. ∴tissue stem/progenitor cells are easier to become cancer cells because they are closer to neural stemness www.science.org/doi/10.1126/...
