The Ragusa Laboratory
We study selective autophagy in yeast using a combination of cell biology, biochemical reconstitution and structural biology.
- Reposted by The Ragusa LaboratoryHappy to share the latest from the lab, led by Daniel Alvarez, in collaboration with @lizconibear.bsky.social. In this AA-MD tour-de-force, we delve deep into the mechanism and energetics of lipid uptake by bridge-like lipid transfer proteins, and we learn a few interesting things along the way...
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- Reposted by The Ragusa Laboratory🚨🚨🚨 The Trump administration has laid it out: comply with their ideological agenda or else… This is how we lose free thought in American higher education.
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- Reposted by The Ragusa Laboratory📢 Pre-print alert 📢 We are excited to share the lab's first research article! We used our artificial cortex system to investigate how membrane composition regulates self-organized cortical dyanamics. Check it out here: www.biorxiv.org/content/10.1...
- Reposted by The Ragusa LaboratoryExcited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!
- I'm very excited to share out latest work now published in Autophagy. www.tandfonline.com/doi/full/10.... This work was led by Dr. Devika Andhare and demonstrates the membrane binding and clustering capabilities of Atg11 using a new reconstitution system.
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- Reposted by The Ragusa LaboratoryNorthwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025
- Reposted by The Ragusa LaboratoryMy ongoing request: If your NSF or NIH grant was terminated--whether at Harvard or elsewhere--please report it here. NSF: grant-watch.us/submit-nsf.h... NIH: grant-watch.us/submit-nih.h... Our trackers are actively used in lawsuits and are often the only record that terminations ever occurred.
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- Reposted by The Ragusa LaboratoryIn 100 days in office, US President Donald Trump has destabilized eight decades of government support for science. This has included terminating more than 1,000 grants in areas such as climate change, cancer, and HIV prevention. Will US science survive Trump 2.0? www.nature.com/articles/d41...
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- Reposted by The Ragusa LaboratoryACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n
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- Reposted by The Ragusa LaboratoryExclusive: Weeks after President Donald Trump’s administration ordered NIH to pull $250 million in biomedical research grants to Columbia University, the agency is freezing all remaining grant money owed to the university until further notice. scim.ag/4if5Rg1
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- Reposted by The Ragusa LaboratoryDr. Richard Youle was fired today. He is an eminent scientist who has done important work on brain diseases like dementia and Parkinson’s. Musk and Trump are stopping NIH research into cures, for diseases from cancer to Alzheimer’s. Americans did not vote for this.
- NEW: The doctor behind breakthrough Parkinson’s research was among the scientists purged from the National Institutes of Health, the US’s leading medical research agency. www.wired.com/story/doctor...
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- All institutions across the U.S. should band together now to protect freedom of speech and scientific integrity. We can not wait any longer we have already lost so much. www.dailyprincetonian.com/article/2025...
- Reposted by The Ragusa LaboratoryHere at Princeton, we’re amplifying our university president’s leadership. It’s time for everyone - faculty, students, staff - to speak out. tl;dr: rights can’t be blackmailed. From me and science colleagues: www.dailyprincetonian.com/article/2025...
- Reposted by The Ragusa LaboratoryMajor update over the weekend to our spreadsheet tracking terminated NIH grants. 👇 Improvements include: - more grant metadata, including Congressional reps and their phone numbers - data from more sources to complement PI-submitted information - better data integrity and reproducibility 1/
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- I just heard that a Postbaccalaureate Research Education Program (PREP) grant from the NIH, with several years still remaining on the project, was terminated. PREP has existed for 25 years and trained thousands of scientists. The potential loss of PREP is a huge loss for the scientific community.
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- Last week @standupforscience.bsky.social rally at Dartmouth I spoke with a colleague about the deletion of critical training programs from the NIH's website including the PREP program. PREP has been around since 2000 and has trained thousands of scientists but now its gone from the NIH's website.
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- Reposted by The Ragusa LaboratoryI was hoping that my first bsky post would be more cheerful. I recently joined NIH (NIEHS) as a PO. I fought hard for this position and was so excited to support health science from a new vantage point… I picked up my life and moved to NC. Unfortunately, my time at NIEHS was short lived.
- Our manuscript describing the role of Atg11 in binding and clustering vesicles during selective autophagy is updated on bioRxiv. www.biorxiv.org/content/10.1...
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