Dan Nomura
Professor of Chemical Biology and Molecular Therapeutics at UC Berkeley
- Excited to highlight our latest bioRxiv led by grad student Zoe Duong and Qian Shao. We report a chemistry-centric, chemoproteomics-enabled strategy to discover non-degradative molecular glues for transcriptional rewiring. 🔗 www.biorxiv.org/content/10.6...
- Reposted by Dan NomuraNew preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson! www.biorxiv.org/content/10.1...
- I rarely get to give a research talk at my home institution! Looking forward to giving a talk about our latest research next Tuesday, November 18th, at 2 pm as part of the @innovativegenomics.bsky.social seminar series in Room 115 IGIB at UC Berkeley! innovativegenomics.org/events/semin...
- Reposted by Dan NomuraInduced proximity-based therapeutic modalities nature.com/articles/s41... rdcu.be/eOfBH This new Review by @dannomura.bsky.social et al. discusses the rapidly expanding landscape of therapeutic approaches based on inducing proximity between proteins, including targeted protein degraders and more
- New from the Cravatt Lab! Tryptoline stereoprobes reveal hidden cysteine ligandability: while Boltz-2 nails orthosteric sites but burns out on non-orthosteric ones. A masterpiece of chemoproteomics + AI. 🔗 doi.org/10.1101/2025...
- We unveil TRACERs, Transcriptional Regulation via Active Control of Epigenetic Reprogramming: a new small-molecule-based induced-proximity modality that silences transcription factors by recruiting endogenous corepressor complexes for locus-specific repression. www.biorxiv.org/content/10.1...
- TRACERs enable epigenetic silencing of transcription factors through fully small-molecule control. We demonstrate that TRACERs can potently and selectively repress the transcriptional programs of estrogen receptor (ER) and androgen receptor (AR/AR-V7).
- Looking forward to seeing friends and giving a talk about our latest research at @stanfordchemistry.bsky.social @stanforduniversity.bsky.social tomorrow! chemistry.stanford.edu/events/chemi...
- We’re happy to highlight our newest @biorxivpreprint.bsky.social by postdoc Thang Cong Do and Octant on the discovery of a direct-acting, covalent destabilizing degrader of immune & cancer transcription factors IRF8 & IRF5! Also thanks to @themarkfdn.bsky.social ! www.biorxiv.org/content/10.1...
- This paper now out in ACS Central Science!! pubs.acs.org/doi/10.1021/...
- Excited to highlight our latest preprint by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique C173 and C178, on the E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders. www.biorxiv.org/content/10.1...
- Awesome to be back in Cambridge for #ChemBiointhePub ahead of the Bioorganic Chemistry GRC!
- Our latest paper w/ @pottslab.bsky.social & @amgen.bsky.social in @jacs.acspublications.org by co-first authors @cmzammit.bsky.social & Cory Nadel on discovery of covalent destabilizing degrader of AR & AR-V7 in prostate cancer. Thanks also to @themarkfdn.bsky.social ! pubs.acs.org/doi/10.1021/...
- Reposted by Dan NomuraExcited to announce a new collaboration between the Molecular Therapeutics Initiative (MTI) and Amgen Inc.! This partnership includes funding for cutting-edge research & an internship program for grad students to train in drug discovery & development at Amgen. #MTI #Amgen #Biotech #UCB
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- Reposted by Dan NomuraThrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Skytorial! 1/9
- Congrats to chem bio grad students Ellie King, Lauren Orr, and Vienna Thomas on graduating with their PhD's!
- Our 2025 lab photo!
- Reposted by Dan Nomura- Mutations mimicking glues by @brianliau.bsky.social al and Ning Zheng - Covalent and bivalent glue engagement by @dannomura.bsky.social, Nathanael Gray, @georgwinter.bsky.social and @alessiociulli.bsky.social - And finish it of with a discussion on general mode-of-action.
- Reposted by Dan NomuraExcited that our work revealing the structure and function of the monster stress response silencing factor, the E3 ligase SIFI, is now out! Congratulations to the most amazing team of Zhi Yang, Diane Haakonsen, Michael Heider and Sam Witus! www.nature.com/articles/s41...
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- Excited to highlight our latest preprint by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique C173 and C178, on the E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders. www.biorxiv.org/content/10.1...
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- Excited to moderate a panel at the @theaacr.bsky.social CICR townhall at #2025AACR on "Charting the Course: Innovating Cancer Drug Discovery in a Challenging Landscape" alongside Shiva Malek, Gwenn Hansen, Ryan Schoenfeld, and Joseph Pearlberg!
- Back in Chicago for #2025AACR! I’ll be giving a talk on our latest work tomorrow in the Educational Session on Advances in Ligand Discovery to Enable Previously Intractable Targets on Sat Apr 26th 2:30-4:00pm in S406 McCormick South alongside @michael-erb.bsky.social & @xiaoyuzhang.bsky.social !
- Amazing talk yesterday by @rushika-perera.bsky.social for our Molecular Therapeutics seminar series!
- Had such an awesome time at @themarkfdn.bsky.social symposium today!!
- Amazing Quality Control Life Processes conference in Frankfurt organized by @idikic.bsky.social !! Great science, great friends!
- Cool paper from Woo lab: biorxiv.org/content/10.1101/202…
- Cool paper from Rullo lab: www.nature.com/articles/s41...
- Cool paper from Crabtree and Gray labs: www.biorxiv.org/content/10.1...
- Reposted by Dan NomuraA pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved
- Cool paper from Parker lab: www.biorxiv.org/content/10.1...
- Amazing meeting last week in Germany: 130th International Titisee Conferences on Stress Signalling in Development and Disease organized by Brenda Schulman & @micharapelab.bsky.social !
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- Reposted by Dan NomuraYou want my thoughts? I'll give you my thoughts...🤬🤬🤬🤬🤬 Oh, you want my understanding of why this is happening? There is no reasonable justification not to have these scheduled at this point. Even if they need to sort out dealing with applications that include "forbidden" topics, schedule now.
- Reposted by Dan NomuraNIH announces that it will move all grant reviews to Center for Scientific Review (CSR) and terminate about half of its review staff. This comes as there is already a building backlog from cancelled review meetings and layoffs. "We're already massively behind schedule," a review officer tells me.
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- Cool paper from Cravatt lab on an allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes www.nature.com/articles/s41...
- New @biorxivpreprint.bsky.social from our lab, Maimone lab, and @novartis.bsky.social on a covalent destabilizing degrader of myc that acts through stereoselective targeting of an IDR C203 in MYC! Congrats to first authors Hannah Rosen and Kelvin Li! www.biorxiv.org/content/10.1...
- Cool paper from Matt Bogyo’s lab: pubs.acs.org/doi/10.1021/...
- Headed to Boston to give a talk about our latest research at MIT Biological Engineering hosted by Angela Koehler and then visit my friends at @novartis.bsky.social ! Look out for a new Biorxiv coming out of our lab imminently on a new covalent MYC degrader! be.mit.edu/our-communit...
- After an awesome Targeted Protein Degradation Keystone meeting last week, happy to be back @ethzurich.bsky.social this week to give a talk about our latest work alongside the great @songlin1.bsky.social ! chab.ethz.ch/en/research/...
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- Reposted by Dan NomuraNew York Times article now up on Federal Register stuff. www.nytimes.com/2025/02/21/s... 1/n
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- Reposted by Dan Nomura"These kinds of shocks are going to lead to a mass exodus … for minorities in particular.” For my latest @science.org story, I spoke with early career researchers who have been affected by the federal upheaval and are concerned about what it means for their future. www.science.org/content/arti...
- Reposted by Dan NomuraI agree. It seems extremely unlikely that they are trying to get grants flowing again. One of my concerns is that they may be hoping to delay things enough that NIH will not have time to get appropriated funds issued by September 30th, the end of the fiscal year. 1/n
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- Cool preprint from Ben Cravatt and Phil Baran: www.biorxiv.org/content/10.1...
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- I’m a standing member on the Chemical Biology and Probes (CBP) NIH study section that was supposed to meet tomorrow. It just got postponed this afternoon with a date yet to be determined….
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- Our latest BioRxiv by @cmzammit.bsky.social, Cory Nadel, @pottslab.bsky.social on a covalent destabilizing degrader against AR & AR-V7 in prostate cancer that targets an IDR C125 to destabilize, inhibit, and degrade TF! Thanks to @amgen.bsky.social, MTI, Berkeley MCB/Chemistry, NCI, TMFCR, and NSF!
- Reposted by Dan NomuraToday in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
