Ethan Hollingsworth
MD/PhD Student in the Kvon Lab at UC Irvine
Gene regulation in development and disease.
- Reposted by Ethan HollingsworthIt’s not about drugs. If it was, Trump wouldn’t have pardoned one of the largest narco traffickers in the world last month. It’s about oil and regime change. And they need a trial now to pretend that it isn’t. Especially to distract from his sinking under Epstein and skyrocketing healthcare costs.
- From synthetic sequence to mammalian tissue-specific activity?! 🤯 Loved contributing to this awesome collaboration with @shenzhichen1999.bsky.social, Vincent Loubiere, @alex-stark.bsky.social, @evgenykvon.bsky.social, @jmschreiber91.bsky.social. So many possibilities in this space!
- Our preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
- A call to arms for research universities "We need to get up from under our desks and persuade our fellow citizens that the institutions that they have helped create with their tax dollars are incredibly precious and important."
- Reposted by Ethan Hollingsworth[Not loaded yet]
- Reposted by Ethan HollingsworthPlease RP. We are thrilled to announce that our lab’s first preprint is out! ”Whole-genome single-cell multimodal history tracing to reveal cell identity transition” We report HisTrac-seq, a multiomic single-cell molecular recording platform. www.biorxiv.org/content/10.1...
- Reposted by Ethan HollingsworthSharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
- Reposted by Ethan HollingsworthExcited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
- Reposted by Ethan Hollingsworth🚨 Our parent-of-origin study is out in Nature! 🧬 Maternal and paternal alleles can have distinct — even opposite — effects on human traits, revealing a hidden layer of genetic architecture that standard GWAS miss. 🔗 www.nature.com/articles/s41... Highlights below!
- Exactly 7 years (to the day) after packing my car up and leaving for California, I successfully defended my PhD in the the lab of @evgenykvon.bsky.social! Incredibly grateful to Evgeny, the lab, my family, and many more whose support made this possible
- Reposted by Ethan HollingsworthFinally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
