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  Jonathan Frazer jonnyfrazer.bsky.social · Oct 23, 2025
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  Charlie Pugh cwjpugh.bsky.social · May 26, 2025
  New preprint in collaboration with @paulinanunezv.bsky.social supervised by @jonnyfrazer.bsky.social and Mafalda Dias – we propose a simple approach to improving zero-shot variant effect prediction in pre-existing protein and genome language models: 🧶 1/n www.biorxiv.org/content/10.1...
  

  From Likelihood to Fitness: Improving Variant Effect Prediction in Protein and Genome Language Models

  Generative models trained on natural sequences are increasingly used to predict the effects of genetic variation, enabling progress in therapeutic design, disease risk prediction, and synthetic biolog...

  biorxiv.org
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  Jonathan Frazer jonnyfrazer.bsky.social · May 22, 2025
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  Isabelle Zane isabellease.bsky.social · May 22, 2025
  @cwjpugh.bsky.social at #VariantEffect25
  
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  Kevin K. Yang 楊凱筌 kevinkaichuang.bsky.social · Dec 3, 2024
  Three BioML starter packs now! Pack 1: go.bsky.app/2VWBcCd Pack 2: go.bsky.app/Bw84Hmc Pack 3: go.bsky.app/NAKYUok DM if you want to be included (or nominate people who should be!)
  at://did:plc:vcfu4zw4mstjnpvqb7yqby32/app.bsky.graph.starterpack/3lapi2tgwmz2y
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